ErbB3 binding protein 1 contributes to adult hippocampal neurogenesis by modulating Bmp4 and Ascl1 signaling
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Neural stem cells (NSCs) in the adult hippocampus divide infrequently;the endogenous molecules modulating adult hippocampalneurogenesis (AHN) remain largely unknown. Here,we show that ErbB3 binding protein 1 (Ebp1), which plays importantroles in embryonic neurodevelopment, acts as an essentialmodulator of adult neurogenic factors. In vivo analysisof Ebp1 neuron depletion mice showed impaired AHN with alow number of hippocampal NSCs and neuroblasts. Ebp1 leadsto transcriptional repression of Bmp4 and suppression of Ascl1promoter methylation in the dentate gyrus of the adult hippocampusreflecting an unusually high level of Bmp4 and lowAscl1 level in neurons of Ebp1-deficient mice. Therefore, ourfindings suggests that Ebp1 could act as an endogenous modulatorof the interplay between Bmp4 and Ascl1/Notch signaling,contributing to AHN.
Abstract
Neural stem cells (NSCs) in the adult hippocampus divide infrequently;the endogenous molecules modulating adult hippocampalneurogenesis (AHN) remain largely unknown. Here,we show that ErbB3 binding protein 1 (Ebp1), which plays importantroles in embryonic neurodevelopment, acts as an essentialmodulator of adult neurogenic factors. In vivo analysisof Ebp1 neuron depletion mice showed impaired AHN with alow number of hippocampal NSCs and neuroblasts. Ebp1 leadsto transcriptional repression of Bmp4 and suppression of Ascl1promoter methylation in the dentate gyrus of the adult hippocampusreflecting an unusually high level of Bmp4 and lowAscl1 level in neurons of Ebp1-deficient mice. Therefore, ourfindings suggests that Ebp1 could act as an endogenous modulatorof the interplay between Bmp4 and Ascl1/Notch signaling,contributing to AHN.
참고문헌 (32)
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