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Chloral hydrate와 Midazolam의 경구투여시 진정효과에 대한 비교

A comparative evaluation of oral chloral hydrate vs. oral midazolamin sedative effect

이상호|이창섭|이난영|오명신
대한소아치과학회 (The Korean Academy Of Pediatric Dentistry)|2005.03|대한소아치과학회지 (Journal of the Korean academy of pediatric dentistry)|제32권 제1호|pp. 40-48

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참고문헌

키워드

진정Sedationchloral hydratemidazolam경구투여oral administration
주제분류치의학

초록

전신상태가 양호하며 2회 이상의 치료가 필요한 남아 10명 여아 12명 총 22명의 환아를 대상으로 chloral hydrate(PocralⓇ syrup, 한림제약) 60mg/kg와 hydroxyzine(UceraxⓇ정,한국 유씨비제약) 25mg을 병용투여한 군과 midazolam(DormicumⓇ, 주, 한국로슈) 0.5mg/kg과 hydroxyzine(UceraxⓇ syrup, 한국 유씨비제약) 25mg을 병용투여한 군을 각각 I군과 Ⅱ군으로 구분하였다. 약물 투여 30분 후 치과치료를 시행하였으며 치료과정을 6단계로 구분하여 각 단계별로 수면지수와 울음지수, 움직임지수, 전반적인 행동지수를 측정, 비교하여 다음과 같은 결과를 얻었다. 1. 전반적인 행동지수를 기준으로 성공률을 평가한 결과 I군은 59.2%, Ⅱ군은 77.3%의 성공률을 보였다(p<0.05). 2. 수면지수는 I군에서 평균 1.81±0.93으로 Ⅱ군의 1.44±0.69에 비해 유의하게 깊은 수면상태를 보였다(p<0.05). 3. 울음지수, 움직임지수, 전반적인 행동지수는 군 간에 유의한 차이가 없었다(p>0.05). 4. 성별에 따른, 연령에 따른 군 간에 유의한 차이가 없었다(p>0.05). 위와 같은 결과를 종합하여 볼 때 midazolam의 경구투여는 적절한 진정효과를 가지는 방법으로 어린환자의 치과치료시 유용하게 사용될 수 있을 것으로 사료된다.

Abstract

The purpose of present study was to compare the sedative effect of chloral hydrate and oral midazolam treatment. The study was conducted on twenty two child patients who required at least two visits. All the patients showed a good physical status (ASA-I). The patient was randomly assigned to receive drug either chloral hydrate 60mg/kg and hydroxyzine 25mg(Group I) or midazolam 0.5mg/kg and hydroxyzine 25mg(Group Ⅱ) at each visit. Treatment procedures were divided into six stages. In each stage, sleep , crying , movement and overall behavior score were evaluated. The overall results can be summarized as follows: 1. Success rate was 59.9% in group I and was 77.8% in Group Ⅱ. 2. Mean sleep score was 1.81±0.93 in group I and was 1.44±0.69 in group Ⅱ (P<0.05). 3. Through all treatment procedures, no significant difference was observed between group I and group Ⅱ in terms of crying, movement and overall behavior score(P>0.05). 4. There was no significant difference between the sex and the age(P>0.05). In regard to above results, oral midazolam considered to be a valuable drug as sedative agent in pediatric dentistry.

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