성장기 쥐의 편측 교근에 주사한 보툴리눔 A형 독소가 하악골 성장에 미치는 영향
THE MANDIBULAR GROWTH EFFECT OF THE BOTULINUM TOXIN TYPE A INJECTION INTO UNILATERAL MASSSTER MUSCLE OF GROWING RAT
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성장 시기가 다른 쥐의 편측 교근에 보툴리눔 A형 독소를 주사하여 하악골 성장에 미치는 영향을 알아보고자 하였다. 각기 다른 주령의 쥐(N=36, 1군: 4주령, 2군: 5주령, 3군: 6주령)를 대상으로 실험을 시행하였으며 각 군은 다시 대조 군, 편측주사군, 양측주사군으로 나누어 하악골의 길이를 계측하고 다음과 같은 결과를 얻었다. 1. 1군에서 편측주사군의 주사측과 양측주사군 모두 하악체 길이, 과두 높이가 대조군 보다 낮은 값을 보였다(p<0.05). 2. 2군에서 편측주사군의 주사측과 양측주사군 모두 하악 전방부 높이와 과두높이에서 대조군 보다 낮은 값을 보였다 (p<0.05). 3. 3군에서 편측주사군의 주사측과 양측주사군 모두 하악체 길이와 과두 높이, 과두돌기 높이가 대조군 보다 낮은 값을 보 였다(p<0.05). 4. 세 군 모두 편측주사군의 양측 비교시 통계적으로 유의한 차이는 없었으나 주사측은 대조측 보다 낮은 계측값을 보이는 경향이 관찰되었다(p>0.05).
Abstract
The purpose of this study was to assess the effect on mandibular growth of botulinum toxin type A (BTXA) injection into the unilateral massester muscle of growing rats at three different growing stages. Thirty six male Sprague-Dawley rats were divided into three groups according to the age (group 1: 4 weekold, group 2: 5week-old, group 3: 6week-old). Then each group was randomly divided into 3 subgroups (control group, unilateral injection group, bilateral injection group). Experimental animals were sacrificed after 4 weeks. Then the jaw measurements were evaluated. The results were as follows: 1. In the group 1, mandibular body length, condylar height and coronoid process height of the unilateral group(BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 2. In the group 2, anterior region height, condylar height, coronoid process height of the unilateral group (BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 3. In the group 3, mandibular body length, condylar height, coronoid process height of the unilateral group (BTXA side) and the bilateral group were shorter than those of the control group (p<0.05). 4. There was no significant difference in mandibular measurements between the control side and the injection side in the unilateral group in all age groups (p>0.05).
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