Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro
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Background and Objectives This study aimed at examining the effects of photobiomodulation therapy (PBMT) on glucose, cholesterol, triglycerides, and low- and high-density lipoprotein (LDL and HDL, respectively) levels in vitro. Materials and Methods A total of 38 serum samples collected in plain (n=10) and heparinized tubes (n=28) were subjected to PBMT at 60 Joules (J)/cm2 for 2 min at 810 nm. The glucose and lipid profiles, cholesterol, triglycerides, LDL, and HDL of each sample was measured before and after PBMT. Results A statistically significant increase in glucose levels was observed in the PBMT-sera in 8 out of 10 samples in plain tubes. However, only two samples that were prepared in heparinized tubes showed an increase in glucose levels. The remaining heparinized samples that were exposed to PBMT presented lower glucose values. The treated sera exhibited a fluctuation in the lipid profiles after PBMT. However, high cholesterol levels were evident following PBMT. Similar trends with HDL and LDL in heparinized tubes were evident. Conclusion Together, the findings suggest that photobiomodulation exhibits an effect on glycemic and lipid profiles in vitro. Hence, the use of low-level laser therapy could have therapeutic potential. However, the differences between individual responses appear to indicate that the impact of PBMT may not always be beneficial.
Abstract
Background and Objectives This study aimed at examining the effects of photobiomodulation therapy (PBMT) on glucose, cholesterol, triglycerides, and low- and high-density lipoprotein (LDL and HDL, respectively) levels in vitro. Materials and Methods A total of 38 serum samples collected in plain (n=10) and heparinized tubes (n=28) were subjected to PBMT at 60 Joules (J)/cm2 for 2 min at 810 nm. The glucose and lipid profiles, cholesterol, triglycerides, LDL, and HDL of each sample was measured before and after PBMT. Results A statistically significant increase in glucose levels was observed in the PBMT-sera in 8 out of 10 samples in plain tubes. However, only two samples that were prepared in heparinized tubes showed an increase in glucose levels. The remaining heparinized samples that were exposed to PBMT presented lower glucose values. The treated sera exhibited a fluctuation in the lipid profiles after PBMT. However, high cholesterol levels were evident following PBMT. Similar trends with HDL and LDL in heparinized tubes were evident. Conclusion Together, the findings suggest that photobiomodulation exhibits an effect on glycemic and lipid profiles in vitro. Hence, the use of low-level laser therapy could have therapeutic potential. However, the differences between individual responses appear to indicate that the impact of PBMT may not always be beneficial.
참고문헌 (27)
- King PR, "Low level laser therapy : a review", Laser Med Sci, 4, pp.141~ (1989)
- Derkacz A, "Usefulness of intravascular low-power laser illumination in preventing restenosis after percutaneous coronary intervention", Am J Cardiol, 106, pp.1113~1117 (2010)
- Derkacz A, "Effect of the intravascular low energy laser illumination during percutaneous coronary intervention on the inflammatory process in vascular wall", Lasers Med Sci, 28, pp.763~768 (2013)
- Avci P, "Lowlevel laser therapy for fat layer reduction : a comprehensive review", Lasers Surg Med, 45, pp.349~357 (2013)
- Ferraresi C, "Effects of low level laser therapy(808 nm)on physical strength training in humans", Lasers Med Sci, 26, pp.349~358 (2011)
- Paolillo FR, "Effects of infrared-LED illumination applied during high-intensity treadmill training in postmenopausal women", Photomed Laser Surg, 29, pp.639~645 (2011)
- Huang YY, "Biphasic dose response in low level light therapy-an update", Dose Response, 9, pp.602~618 (2011)
- Góralczyk K, "Effect of LLLT on endothelial cells culture", Lasers Med Sci, 30, pp.273~278 (2015)
- Szymczyszyn A, "Effect of the transdermal lowlevel laser therapy on endothelial function", Lasers Med Sci, 31, pp.1301~1307 (2016)
- Tsai SR, "Biological effects and medical applications of infrared radiation", J Photochem Photobiol B, 170, pp.197~207 (2017)
- Pasternak K, "The effect of MLS laser radiation on cell lipid membrane", Ann Agric Environ Med, 25, pp.108~113 (2018)
- Brill AG, "Blood irradiation by He-Ne laser induces a decrease in platelet responses to physiological agonists and an increase in platelet cyclic GMP", Platelets, 11, pp.87~93 (2000)
- Blatt A, "Low-level laser therapy to the bone marrow reduces scarring and improves heart function post-acute myocardial infarction in the pig", Photomed Laser Surg, 34, pp.516~524 (2016)
- Bomfim FRCD, "Influence of low-level laser irradiation on osteocalcin protein and gene expression in bone tissue1", Acta Cir Bras, 33, pp.736~743 (2018)
- Tuby H, "Modulations of VEGF and iNOS in the rat heart by low level laser therapy are associated with cardioprotection and enhanced angiogenesis", Lasers Surg Med, 38, pp.682~688 (2006)
- Chen CH, "Low-energy laser irradiation increases endothelial cell proliferation, migration, and eNOS gene expression possibly via PI3K signal pathway", Lasers Surg Med, 40, pp.46~54 (2008)
- Elblbesy MA, "Comparative in vitro study : examining 635nm laser and 265nm ultraviolet interaction with blood", Photobiomodul Photomed Laser Surg, 37, pp.342~348 (2019)
- Fridoni M, "Improvement in infected wound healing in type 1 diabetic rat by the synergistic effect of photobiomodulation therapy and conditioned medium", J Cell Biochem, 120, pp.9906~9916 (2019)
- Forney R, "Using lasers in diabetic wound healing", Diabetes Technol Ther, 1, pp.189~192 (1999)
- Gogia PP, "Wound management with whirlpool and infrared cold laser treatment. A clinical report", Phys Ther, 68, pp.1239~1242 (1988)
- Yu W, "Effects of photostimulation on wound healing in diabetic mice", Lasers Surg Med, 20, pp.56~63 (1997)
- Jenkins PA, "How to report low-level laser therapy(LLLT)", photomedicine dose and beam parameters in clinical and laboratory studies, 2011, pp.29, 785~787
- Francisco CO, "Effects of light-emitting diode therapy(LEDT)on cardiopulmonary and hemodynamic adjustments during aerobic exercise and glucose levels in patients with diabetes mellitus : a randomized, crossover, doubleblind and placebo-controlled clinical trial", Complement Ther Med, 42, pp.178~183 (2019)
- Góralczyk K, "Low-level laser irradiation modifies the effect of hyperglycemia on adhesion molecule levels", Lasers Med Sci, 33, pp.1521~1526 (2018)
- Fukuoka CY, "Lowpower laser irradiation in salivary glands reduces glycemia in streptozotocin-induced diabetic female rats", J Biophotonics, 9, pp.1246~1254 (2016)
- Croghan IT, "Low-level laser therapy for weight reduction : a randomized pilot study", Lasers Med Sci, 35, pp.663~675 (2020)
- Aquino AE Jr, "Low-level laser therapy(LLLT)combined with swimming training improved the lipid profile in rats fed with high-fat diet", Lasers Med Sci, 28, pp.1271~1280 (2013)