Photodynamic Therapy Combined with 1064-nm Nd:YAG Laser Therapy and Topical Efinaconazole for Refractory Onychomycosis: Case Series
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Onychomycosis is the most common disease of the nail, with a worldwide prevalence of 5.5%. It causes local pain, paresthesia, and cosmetic problems and decreases the patients’ quality of life. Conventional treatments include the administration of topical and systemic agents. However, factors such as subungual hyperkeratosis and biofilm formation may affect the efficacy of these treatments. Moreover, side effects associated with systemic agents are a major concern for patients. Therefore, various novel treatments are being developed; among them, photodynamic therapy (PDT) and Nd:YAG laser are promising, and several studies have demonstrated the efficacy and safety of PDT and laser therapy. Here, we report the efficacy and tolerability of PDT combined with 1064-nm Nd:YAG laser therapy and topical efinaconazole for the treatment of three patients with refractory onychomycosis.
Abstract
Onychomycosis is the most common disease of the nail, with a worldwide prevalence of 5.5%. It causes local pain, paresthesia, and cosmetic problems and decreases the patients’ quality of life. Conventional treatments include the administration of topical and systemic agents. However, factors such as subungual hyperkeratosis and biofilm formation may affect the efficacy of these treatments. Moreover, side effects associated with systemic agents are a major concern for patients. Therefore, various novel treatments are being developed; among them, photodynamic therapy (PDT) and Nd:YAG laser are promising, and several studies have demonstrated the efficacy and safety of PDT and laser therapy. Here, we report the efficacy and tolerability of PDT combined with 1064-nm Nd:YAG laser therapy and topical efinaconazole for the treatment of three patients with refractory onychomycosis.
참고문헌 (10)
- de Berker D, "Clinical practice. Fungal nail disease", N Engl J Med, 360, pp.2108~2116 (2009)
- Gupta AK, "How do we measure efficacy of therapy in onychomycosis : patient, physician, and regulatory perspectives", J Dermatolog Treat, 27, pp.498~504 (2016)
- Elewski B, "Current and emerging options in the treatment of onychomycosis", Semin Cutan Med Surg, 32(2 Suppl 1), pp.S9~S12 (2013)
- Graybill JR, "Fungal infections and their management", Br J Clin Pract Suppl, 71, pp.23~31 (1990)
- Bhatta AK, "Photodynamic therapy for onychomycosis : a systematic review", Photodiagnosis Photodyn Ther, 15, pp.228~235 (2016)
- Liddell LT, "Laser therapy for onychomycosis: fact or fiction?", J Fungi (Basel), 1, pp.44~54 (2015)
- Kamp H, "Antifungal effect of 5-aminolevulinic acid PDT in Trichophyton rubrum", Mycoses, 48, pp.101~107 (2005)
- Noguchi H, "Treatment of onychomycosis using a 1064nm Nd : YAG laser", Med Mycol J, 54, pp.333~339 (2013)[DOI]
- Souza LW, "Distal and lateral toenail onychomycosis caused by Trichophyton rubrum : treatment with photodynamic therapy based on methylene blue dye", An Bras Dermatol, 89, pp.184~186 (2014)
- Tardivo JP, "Small scale trial of photodynamic treatment of onychomycosis in São Paulo", J Photochem Photobiol B, 150, pp.66~68 (2015)