Effect of micro-vibration treatment in a blepharitis rat model
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Blepharitis, a chronic inflammatory condition of the eyelid margin, can cause significant discomfort and impair the quality of life. While traditional treatments like eyelid hygiene and medications are often insufficient, non-invasive therapies such as micro-vibration devices are gaining popularity despite minimal empirical validation. This study evaluated the efficacy and safety of a commercially available microvibration device in a rat model of blepharitis. Methods: Blepharitis was induced in rats using complete Freund’s adjuvant injections. The treatment groups included micro-vibration (180 Hz), micro-vibration with thermal enhancement, and pharmacological interventions with cyclosporine or hyaluronic acid. Ocular signs, including tear break-up time (TBUT), fluorescein staining, eyelid swelling, and telangiectasia, were assessed weekly. Immunohistochemical analysis quantified inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor-α) in ocular tissues. Results: The micro-vibration therapy significantly improved TBUT, reduced eyelid swelling, and lowered inflammatory cytokine levels. Combining thermal therapy with micro-vibration yielded enhanced antiinflammatory effects, though uncontrolled heating caused tissue damage. Pharmacological treatments were effective but less comprehensive compared to micro-vibration therapies. Conclusion: Micro-vibration therapy at 180 Hz demonstrated substantial efficacy in alleviating symptoms of blepharitis and reducing inflammation. However, the uncontrolled thermal function of the device posed safety concerns, emphasizing the need for stringent regulation and parameter control in commercially available devices. This study highlights the potential of micro-vibration therapy as a non-invasive treatment for blepharitis while underscoring the importance of device safety.
Abstract
Background: Blepharitis, a chronic inflammatory condition of the eyelid margin, can cause significant discomfort and impair the quality of life. While traditional treatments like eyelid hygiene and medications are often insufficient, non-invasive therapies such as micro-vibration devices are gaining popularity despite minimal empirical validation. This study evaluated the efficacy and safety of a commercially available microvibration device in a rat model of blepharitis. Methods: Blepharitis was induced in rats using complete Freund’s adjuvant injections. The treatment groups included micro-vibration (180 Hz), micro-vibration with thermal enhancement, and pharmacological interventions with cyclosporine or hyaluronic acid. Ocular signs, including tear break-up time (TBUT), fluorescein staining, eyelid swelling, and telangiectasia, were assessed weekly. Immunohistochemical analysis quantified inflammatory cytokines (interleukin [IL]-1β, IL-6, and tumor necrosis factor-α) in ocular tissues. Results: The micro-vibration therapy significantly improved TBUT, reduced eyelid swelling, and lowered inflammatory cytokine levels. Combining thermal therapy with micro-vibration yielded enhanced antiinflammatory effects, though uncontrolled heating caused tissue damage. Pharmacological treatments were effective but less comprehensive compared to micro-vibration therapies. Conclusion: Micro-vibration therapy at 180 Hz demonstrated substantial efficacy in alleviating symptoms of blepharitis and reducing inflammation. However, the uncontrolled thermal function of the device posed safety concerns, emphasizing the need for stringent regulation and parameter control in commercially available devices. This study highlights the potential of micro-vibration therapy as a non-invasive treatment for blepharitis while underscoring the importance of device safety.
참고문헌 (19)
- Bernardes TF, "Blepharitis", Semin Ophthalmol, 25, pp.79~83 (2010)
- Eberhardt M, "Blepharitis" (2024), StatPearls
- Gedar Totuk OM, "Acute allergic reaction caused by topical azithromycin eye drops : a report of two cases", Saudi J Ophthalmol, 33, pp.180~182 (2019)
- Ricardo JW, "Ocular adverse events associated with topical corticosteroid use in dermatology : a systematic review", J Am Acad Dermatol, 88, pp.897~898 (2023)
- Arita R, "Non-pharmaceutical treatment options for meibomian gland dysfunction", Clin Exp Optom, 103, pp.742~755 (2020)
- Lee JE, "A randomised controlled trial comparing a thermal massager with artificial teardrops for the treatment of dry eye", Br J Ophthalmol, 98, pp.46~51 (2014)
- Park Y, "Effect of low-level light therapy in patients with dry eye : a prospective, randomized, observermasked trial", Sci Rep, 12, pp.3575~ (2022)
- Vigo L, "Short-term effects of a novel eye mask producing heat and vibration for the treatment of meibomian gland dysfunction : a pilot study", J Ophthalmol, 2021, pp.1370002~ (2021)
- Tzen YT, "Increased skin blood flow during low intensity vibration in human participants : analysis of control mechanisms using short-time Fourier transform", PLoS One, 13, pp.e0200247~ (2018)
- Needs D, "Effect of localized vibration massage on popliteal blood flow", J Clin Med, 12, pp.2047~ (2023)
- Piwek L, "The rise of consumer health wearables : promises and barriers", PLoS Med, 13, pp.e1001953~ (2016)
- Natalucci V, "The effectiveness of wearable devices in non-communicable diseases to manage physical activity and nutrition : where we are?", Nutrients, 15, pp.913~ (2023)
- Alsoudi AF, "An evaluation of popular online eye health products on amazon marketplace", Ophthalmic Surg Lasers Imaging Retina, 54, pp.147~152 (2023)
- Hayashi N, "Acute and chronic periocular massage for ocular blood flow and vision : a randomized controlled trial", Int J Ther Massage Bodywork, 14, pp.5~13 (2021)
- Páez A, "Beyond the RCT : when are randomized trials unnecessary for new therapeutic devices, and what should we do instead?", Ann Surg, 275, pp.324~331 (2022)
- Resnik DB, "The precautionary principle and medical decision making", J Med Philos, 29, pp.281~299 (2004)
- Edwards JH, "Vibration stimuli and the differentiation of musculoskeletal progenitor cells : review of results in vitro and in vivo", World J Stem Cells, 7, pp.568~582 (2015)
- Azuma M, "Effects of micro vibration therapy nursing care on muscle hardness and skin blood flow : a pre", post group comparison study, 2021, pp.13, 1511~1529
- Bernardo-Filho M, "Alleviation of symptoms in blepharitis with acupuncture and vibration in an oscillating platform : a case report", Adapt Med, 6, pp.32~37 (2014)