Phototherapy for osteoarthritis management: a narrative review
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Osteoarthritis (OA) is characterized by chronic joint degeneration, particularly prevalent in the aging population. Current therapeutic options to address the symptoms of pain and reduced mobility provide limited relief and carry a significant risk of adverse effects. Thus, there is a need to explore non-invasive alternative therapies to manage OA symptoms while preventing disease progression and promoting joint tissue regeneration. This review examined studies conducted in the last 10 years to determine the potential of light-based therapy, particularly focusing on three key aspects: pain management and improvement of articular function; use of complementary light therapy; and stimulation of articular cartilage repair. Various studies have investigated the efficacy of phototherapy, particularly low-level laser therapy, in alleviating pain, improving functionality, and enhancing articular cartilage repair in OA patients. Efforts have also been made to investigate the regenerative potential of phototherapy in stimulating articular cartilage repair. Despite promising findings, several challenges remain, including the lack of standardized testing methods for evaluating the efficacy of laser therapy on OA joints and the need for further research to bridge the gap between early-stage OA in humans and the advanced stages of the disease. Nonetheless, laser therapy presents a non-invasive, well-tolerated treatment option with potential benefits for individuals with OA. Further research is warranted to optimize treatment protocols and explore potential synergistic effects with other interventions.
Abstract
Osteoarthritis (OA) is characterized by chronic joint degeneration, particularly prevalent in the aging population. Current therapeutic options to address the symptoms of pain and reduced mobility provide limited relief and carry a significant risk of adverse effects. Thus, there is a need to explore non-invasive alternative therapies to manage OA symptoms while preventing disease progression and promoting joint tissue regeneration. This review examined studies conducted in the last 10 years to determine the potential of light-based therapy, particularly focusing on three key aspects: pain management and improvement of articular function; use of complementary light therapy; and stimulation of articular cartilage repair. Various studies have investigated the efficacy of phototherapy, particularly low-level laser therapy, in alleviating pain, improving functionality, and enhancing articular cartilage repair in OA patients. Efforts have also been made to investigate the regenerative potential of phototherapy in stimulating articular cartilage repair. Despite promising findings, several challenges remain, including the lack of standardized testing methods for evaluating the efficacy of laser therapy on OA joints and the need for further research to bridge the gap between early-stage OA in humans and the advanced stages of the disease. Nonetheless, laser therapy presents a non-invasive, well-tolerated treatment option with potential benefits for individuals with OA. Further research is warranted to optimize treatment protocols and explore potential synergistic effects with other interventions.
참고문헌 (31)
- Abramoff B, "Osteoarthritis : pathology, diagnosis, and treatment options", Med Clin North Am, 104, pp.293~311 (2020)
- Chen D, "Osteoarthritis : toward a comprehensive understanding of pathological mechanism", Bone Res, 5, pp.16044~ (2017)
- Goldring MB, "Articular cartilage degradation in osteoarthritis", HSS J, 8, pp.7~9 (2012)
- Rai MF, "Pathobiology of human disease", pp.1920~1934 (2014), Academic Press
- Sandell LJ, "Articular cartilage and changes in arthritis. An introduction : cell biology of osteoarthritis", Arthritis Res, 3, pp.107~113 (2001)
- Brody LT, "Knee osteoarthritis : clinical connections to articular cartilage structure and function", Phys Ther Sport, 16, pp.301~316 (2015)
- Hamerman D, "The biology of osteoarthritis", N Engl J Med, 320, pp.1322~1330 (1989)
- Kheshie AR, "High-intensity versus lowlevel laser therapy in the treatment of patients with knee osteoarthritis : a randomized controlled trial", Lasers Med Sci, 29, pp.1371~1376 (2014)
- Hamblin MR, "Can osteoarthritis be treated with light?", Arthritis Res Ther, 15, pp.120~ (2013)
- Soleimanpour H, "The effect of low-level laser therapy on knee osteoarthritis : prospective, descriptive study", Lasers Med Sci, 29, pp.1695~1700 (2014)
- Al Rashoud AS, "Efficacy of low-level laser therapy applied at acupuncture points in knee osteoarthritis : a randomised double-blind comparative trial", Physiotherapy, 100, pp.242~248 (2014)
- Coelho Cde F, "Effectiveness of phototherapy incorporated into an exercise program for osteoarthritis of the knee : study protocol for a randomized controlled trial", Trials, 15, pp.221~ (2014)
- Chen JL, "Intra-articular laser therapy may be a feasible option in treating knee osteoarthritis in elderly patients", Biomed Res Int, 2022, pp.3683514~ (2022)
- Elboim-Gabyzon M, "Laser therapy versus pulsed electromagnetic field therapy as treatment modalities for early knee osteoarthritis : a randomized controlled trial", BMC Geriatr, 23, pp.144~ (2023)
- de Paula Gomes CAF, "Exercise program combined with electrophysical modalities in subjects with knee osteoarthritis : a randomised, placebo-controlled clinical trial", BMC Musculoskelet Disord, 21, pp.258~ (2020)
- Ahmad MA, "Comparison between low-level and highintensity laser therapy as an adjunctive treatment for knee osteoarthritis : a randomized, double-blind clinical trial", Life(Basel), 13, pp.1519~ (2023)
- de Paula Gomes CAF, "Incorporation of photobiomodulation therapy into a therapeutic exercise program for knee osteoarthritis : a placebo-controlled, randomized, clinical trial", Lasers Surg Med, 50, pp.819~828 (2018)
- Vassão PG, "Effects of photobiomodulation and a physical exercise program on the expression of inflammatory and cartilage degradation biomarkers and functional capacity in women with knee osteoarthritis : a randomized blinded study", Adv Rheumatol, 61, pp.62~ (2021)
- Alqualo-Costa R, "Lowlevel laser therapy and interferential current in patients with knee osteoarthritis : a randomized controlled trial protocol", Pain Manag, 8, pp.157~166 (2018)
- Paolillo FR, "Ultrasound plus low-level laser therapy for knee osteoarthritis rehabilitation : a randomized, placebo-controlled trial", Rheumatol Int, 38, pp.785~793 (2018)
- Wu SY, "Combined effect of laser acupuncture and electroacupuncture in knee osteoarthritis patients : a protocol for a randomized controlled trial", Medicine(Baltimore), 99, pp.e19541~ (2020)
- Pan W, "PRPchitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis", Biomaterials, 239, pp.119851~ (2020)
- Tanideh N, "The effects of combined and independent low-level laser and mesenchymal stem cell therapy on induced knee osteoarthritis : an animal study", Knee, 47, pp.208~218 (2024)
- Bahrami H, "Lowlevel laser and light therapy after total knee arthroplasty improves postoperative pain and functional outcomes : a threearm randomized clinical trial", Arthroplast Today, 19, pp.101066~ (2022)
- Moon CH, "Therapeutic effect of irradiation of magnetic infrared laser on osteoarthritis rat model", Photochem Photobiol, 90, pp.1150~1159 (2014)
- Pan TC, "The effects of laser acupuncture on the modulation of cartilage extracellular matrix macromolecules in rats with adjuvant-induced arthritis", PLoS One, 14, pp.e0211341~ (2019)
- Wang Q, "Alleviation of cartilage degeneration by laser acupuncture : an ultrasound biomicroscopic study of early postmenopausal osteoarthritis in rats", Med Nov Technol Devices, 16, pp.100185~ (2022)
- Felizatti AL, "Effects of low-level laser therapy on the organization of articular cartilage in an experimental microcrystalline arthritis model", Lasers Med Sci, 34, pp.1401~1412 (2019)
- Chen IC, "Preventative treatment of red light-emitting diode protected osteoarthritis-like chondrocytes from oxidative stress-induced inflammation and promoted matrix gene expression", J Taiwan Inst Chem Eng, 127, pp.23~31 (2021)
- Xue S, "Cartilagetargeting peptide-modified dual-drug delivery nanoplatform with NIR laser response for osteoarthritis therapy", Bioact Mater, 6, pp.2372~2389 (2021)
- Xu S, "NIR triggered photocatalytic and photothermal bifunctional MOF nanozyme using for improving osteoarthritis microenvironment by repairing injured chondrocytes of mitochondria", Chem Eng J, 468, pp.143826~ (2023)