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상아질 형성부전증의 분자병리학적 고찰

Molecular pathophysiology of dentinogenesis imperfecta

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참고문헌

키워드

주제분류치의학

초록

DSPP의 명확한 기능은 아직 밝혀지지 않았으나, 여러 유전질환에서 볼 수 있듯이 정상적인 상아질의 형성에 필수적이다. 상아질 이형성증 제 I 형의 경우에는 아직 원인유전자가 무엇인지 알려져 있지 않기 때문에 전체 유전성 상아질 결함의 분류를 체계적으로 이해하고, 새로운 분류법을 제안하기에는 아직 시기상조인 면이 있지만, 현재까지의 연구 결과들을 종합해 보면 유전성 상아질 결함이(상아질 이형성증 제 I 형은 제외) 동일 유전자의 이상으로 나타나는 연속적인 임 상적 양상의 한 부분으로 이해할 수 있고, 따라서 상아질 형성 부전증 제 II 형, 제 III 형, 그리고 상아질 이형성증 제 II 형에 서 특징적으로 나타난다고 여겨진 증상들이 일부 중첩되어서 나타나는 것이 더 이상 분류상의 혼란을 야기하지는 않을 것으 로 사료된다.

참고문헌 (42)

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