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QLF를 이용한 항우식 제품의 인공우식 재광화 효과에 대한 연구

Remineralization effect of commercially available anticariogenic products on artificial caries lesion using QLF

이상훈|김종철|김정욱|김영재|장기택|한세현|송주현
대한소아치과학회 (The Korean Academy Of Pediatric Dentistry)|2008.05|대한소아치과학회지 (Journal of the Korean academy of pediatric dentistry)|제35권 제2호|pp. 287-296

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참고문헌

키워드

재광화Quantitative light-induced fluorescence(QLF)Fluoride mouthrinseremineralizationpH cycling system불소 양치액Casein phosphopeptide-amorphous calcium phosphate(CPP-ACP)pH 순환 시스템
주제분류치의학

초록

본 연구는 항우식 제품인 저농도의 불소 양치액(500 ppm NaF)과 Casein phosphopeptide-amorphous calcium phosphate(CPP-ACP)를 포함하는 치아 연고, 그리고 이 두 제품을 같이 사용했을 경우, 인공 우식 병소의 재광화 효과를 알아보고자 하였다. 제3대구치 협면에 인공우식을 유발하였고, 시편을 16개씩 4군으로 나누어, 28일 동안 매일 2회 다음과 같은 항우식 제품을 시편에 처리하였고, pH 순환 시스템을 적용하였다. 1군: 대조군(무처치) 2군: Tooth Mousse(R) (GC Co. Japan) 3군: 치카치카(R) (삼일제약. 한국) 4군: 치카치카(R)+Tooth Mousse(R) 무기질 소실량(ΔQ)의 장기적인 변화를 Quantitative light-induced fluorescence(QLF)를 이용하여 관찰하여 다음과 같은 결과를 얻었다. 1. ΔQ는 1군에서는 28일동안 유의성 있는 차이를 보이지 않았고, 2군과 3군에서는 처치전에 비해 14일부터 유의성 있는 증가를 보였으며, 4군에서는 7일부터 유의성 있는 증가를 보였다. 2. ΔQ는 1군 < 2군, 3군 < 4군 순이었다. 3. ΔQ는 1군과 비교시 2군은 7일, 3군과 4군은 3일부터 유의성 있는 증가를 보였고, 2군은 3군과 전 기간 동안 유의차가 없었다. 4군은 2군과 3군에 비해 28일에 유의성 있는 증가를 보였다. 4. 모든 군에서 재광화 속도는 점차 감소하였다.

Abstract

The purpose of this in vitro study was to compare the remineralization effect of commercially available anticariogenic products, exactly low level fluoride mouthrinse(500 ppm NaF), tooth cream with Casein phosphopeptide-amorphous calcium phosphate(CPP-ACP) and fluoride mouthrinse plus tooth cream on artificial caries lesion. Artificial caries lesion was induced at the buccal surface of permanent third molar and the specimens were then divided(16 specimens/group) into four group. Twice a day during 28 days specimens of each group were treated with a commercially anticariogenic product as follows and applied to the pH cycling system. Group 1: control group (No treatment) Group 2: Tooth Mousse(R) (GC Co. Japan) Group 3: chikachika(R) (Samil Co. Korea) Group 4: chikachika(R)+ Tooth Mousse(R) The long-term change of mineral loss(ΔQ) was evaluated by quantitative light-induced fluorescence (QLF) and the following results were obtained: 1. ΔQ of Group 1 was not noticed statistically significant during 28 days comparing that prior to treatment. There was a statistically significant increase in ΔQ of Group 2 and 3 since 14 days. So was in ΔQ of Group 4 since 7 days. 2. ΔQ was increased as follows: Group 1< Group 2, 3< Group 4. 3. Comparing with Group 1, Group 2 was a statistically significant increase since 7 days and Group 3 and 4 were since 3 days. Comparing Group 2 with 3, there was not noticed statistically significant during whole duration. Group 4 was significantly higher than Group 2 and 3 after 28 days. 4. All groups demonstrated a decrease in the rate of remineralization as time goes on.

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