임신 전 체질량 지수와 임신 중 체중증가가 자녀의 과체중에 미치는 상호작용 영향
Interaction Effects of Pre-Pregnancy Body Mass Index and Gestational Weight Gain on Offspring’s Overweight
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Objectives: Woman with low pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) associated with restricted prenatal growth and offspring's obesity, respectively. In present study, we aim to show the interaction effect of pre-pregnancy BMI and GWG on childhood overweight in 3 years of age. Methods: We followed up subjects in Ewha Birth & Growth Cohort, which is a prospective cohort established 2001~2005. The study subjects consisted of 214 who had informed pre-pregnancy BMI and GWG and theirs offspring participated in the regular examination at 3 years of age. Anthropometric measurements and whole blood sample were done at 3 years of age. The interaction effect of the pre-pregnancy BMI and GWG has been estimated using ANCOVA. Results: Pre-pregnancy BMI categories were assigned the values of low-weight (≤18.5kg/m2), normal weight (18.6~22.9kg/m2), and high weight (>23.0kg/m2) according to the Asia-Pacific standard and GWG was categorized in three group under weight gain, normal weight gain, and over weight gain using gestational weight gain inter-quartiles range according to gestational age. Our study shows that low pre-pregnancy BMI and high pre-pregnancy BMI groups have higher standardized weight at 3 years of age compared to normal pre-pregnancy BMI group. Moreover, pre-pregnancy BMI interacted with gestational weight gain in birth weight (p<0.04) and standardized weight at 3 years of age (p<0.01) when adjusted for maternal age and offspring gender. Conclusions:This study shows that low pre-pregnancy BMI and under GWG are associated with offspring's high weight at early childhood. Therefore, we suggest that it is important for women to maintain normal range of BMI and GWG in pre-pregnancy and pregnancy.
Abstract
Objectives: Woman with low pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) associated with restricted prenatal growth and offspring's obesity, respectively. In present study, we aim to show the interaction effect of pre-pregnancy BMI and GWG on childhood overweight in 3 years of age. Methods: We followed up subjects in Ewha Birth & Growth Cohort, which is a prospective cohort established 2001~2005. The study subjects consisted of 214 who had informed pre-pregnancy BMI and GWG and theirs offspring participated in the regular examination at 3 years of age. Anthropometric measurements and whole blood sample were done at 3 years of age. The interaction effect of the pre-pregnancy BMI and GWG has been estimated using ANCOVA. Results: Pre-pregnancy BMI categories were assigned the values of low-weight (≤18.5kg/m2), normal weight (18.6~22.9kg/m2), and high weight (>23.0kg/m2) according to the Asia-Pacific standard and GWG was categorized in three group under weight gain, normal weight gain, and over weight gain using gestational weight gain inter-quartiles range according to gestational age. Our study shows that low pre-pregnancy BMI and high pre-pregnancy BMI groups have higher standardized weight at 3 years of age compared to normal pre-pregnancy BMI group. Moreover, pre-pregnancy BMI interacted with gestational weight gain in birth weight (p<0.04) and standardized weight at 3 years of age (p<0.01) when adjusted for maternal age and offspring gender. Conclusions:This study shows that low pre-pregnancy BMI and under GWG are associated with offspring's high weight at early childhood. Therefore, we suggest that it is important for women to maintain normal range of BMI and GWG in pre-pregnancy and pregnancy.
참고문헌 (33)
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