임신 중 선천성 거대세포바이러스 감염: 순차적 뇌변화를 보이는 증례 보고와 최신 진단, 치료 및 예방
Congenital Cytomegalovirus Infection in Pregnancy: A Case Report with Sequential Fetal Brain Changes and the Latest Information on Diagnosis, Treatment and Prevention
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초록
Congenital cytomegalovirus (CMV) infection is the most common nongenetic cause of sensorineural hearing loss and a major cause of visual, intellectual, and neurodevelopmental impairment worldwide. The seroprevalence of CMV among women of childbearing age in developing countries reaches almost 100%, and the incidence of CMV infection in neonates is 1%–2%. Approximately 87% of the infected neonates are asymptomatic at birth and 13% of them have permanent sequelae. The burden of congenital malformations due to congenital CMV infection is higher than that due to Down syndrome, fetal alcohol syndrome, and spina bifida. Nevertheless, there is little knowledge regarding congenital CMV pathogenesis, diagnosis, treatment, and prevention. In this study, we report a case that showed sequential changes of fetal brain following CMV infection in pregnancy. Additionally, we reviewed the latest information on the diagnosis, treatment, and prevention of congenital CMV infection.
Abstract
Congenital cytomegalovirus (CMV) infection is the most common nongenetic cause of sensorineural hearing loss and a major cause of visual, intellectual, and neurodevelopmental impairment worldwide. The seroprevalence of CMV among women of childbearing age in developing countries reaches almost 100%, and the incidence of CMV infection in neonates is 1%–2%. Approximately 87% of the infected neonates are asymptomatic at birth and 13% of them have permanent sequelae. The burden of congenital malformations due to congenital CMV infection is higher than that due to Down syndrome, fetal alcohol syndrome, and spina bifida. Nevertheless, there is little knowledge regarding congenital CMV pathogenesis, diagnosis, treatment, and prevention. In this study, we report a case that showed sequential changes of fetal brain following CMV infection in pregnancy. Additionally, we reviewed the latest information on the diagnosis, treatment, and prevention of congenital CMV infection.
참고문헌 (42)
- Adler SP, "Prevention of child-tomother transmission of cytomegalovirus among pregnant women", J Pediatr, 145, pp.485~491 (2004)
- American Academy of Pediatrics, "Year 2007 position statement : principles and guidelines for early hearing detection and intervention programs", Pediatrics, 120, pp.898~921 (2007)
- Barber V, "Prevention of acquisition of cytomegalovirus infection in pregnancy through hygiene-based behavioral interventions : a systematic review and gap analysis", Pediatr Infect Dis J, 39, pp.949~954 (2020)
- Bardanzellu F, "Human breast milk-acquired cytomegalovirus infection: certainties, doubts and perspectives", Curr Pediatr Rev, 15, pp.30~41 (2019)
- Bate SL, "Cytomegalovirus seroprevalence in the United States: the national health and nutrition examination surveys, 1988-2004", Clin Infect Dis, 50, pp.1439~1447 (2010)
- Bodéus M, "Increased risk of cytomegalovirus transmission in utero during late gestation", Obstet Gynecol, 93(5 Pt 1), pp.658~660 (1999)
- Boppana SB, "Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity", N Engl J Med, 344, pp.1366~1371 (2001)
- Boppana SB, "Congenital cytomegalovirus infection : clinical outcome", Clin Infect Dis, 57(Suppl 4), pp.S178~S181 (2013)
- Boppana SB, "Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection", JAMA, 303, pp.1375~1382 (2010)
- Boppana SB, "Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns", N Engl J Med, 364, pp.2111~2118 (2011)
- Cannon MJ, "Review of cytomegalovirus seroprevalence and demographic characteristics associated with infection", Rev Med Virol, 20, pp.202~213 (2010)
- Carlson A, "Cytomegalovirus infection in pregnancy: should all women be screened?", Rev Obstet Gynecol, 3, pp.172~179 (2010)
- Chiopris G, "Congenital cytomegalovirus infection : update on diagnosis and treatment", Microorganisms, 8, pp.1516~ (2020)
- Coats DK, "Ophthalmologic findings in children with congenital cytomegalovirus infection", J AAPOS, 4, pp.110~116 (2000)
- Colomba C, "Congenital cytomegalovirus related intestinal malrotation : a case report", Ital J Pediatr, 42, pp.105~ (2016)
- Dahle AJ, "Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus", J Am Acad Audiol, 11, pp.283~290 (2000)
- De la Calle M, "Combined treatment with immunoglobulin and valaciclovir in pregnant women with cytomegalovirus infection and high risk of symptomatic fetal disease", J Matern Fetal Neonatal Med, 15, pp.1~5 (2020)
- Dollard SC, "New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection", Rev Med Virol, 17, pp.355~363 (2007)
- Dreher AM, "Spectrum of disease and outcome in children with symptomatic congenital cytomegalovirus infection", J Pediatr, 164, pp.855~859 (2014)
- Enders G, "Intrauterine transmission and clinical outcome of 248 pregnancies with primary cytomegalovirus infection in relation to gestational age", J Clin Virol, 52, pp.244~246 (2011)
- Fabbri E, "Prognostic markers of symptomatic congenital human cytomegalovirus infection in fetal blood", BJOG, 118, pp.448~456 (2011)
- Foulon I, "Hearing loss in children with congenital cytomegalovirus infection in relation to the maternal trimester in which the maternal primary infection occurred", Pediatrics, 122, pp.1123~1127 (2008)
- Grosse SD, "Congenital cytomegalovirus(CMV)infection as a cause of permanent bilateral hearing loss : a quantitative assessment", J Clin Virol, 41, pp.57~62 (2008)
- Kenneson A, "Review and meta-analysis of the epidemiology of congenital cytomegalovirus(CMV)infection", Rev Med Virol, 17, pp.253~276 (2007)
- Jiyeon Kim, "Diagnostic Clues for Congenital Cytomegalovirus Infection: Association with Newborn Hearing Screening Tests", Neonatal medicine, 26(2), pp.96~101 (2019), 대한신생아학회[DOI]
- Leruez-Ville M, "In utero treatment of congenital cytomegalovirus infection with valacyclovir in a multicenter, open-label, phase II study", Am J Obstet Gynecol, 215, pp.462.e1~462.e10 (2016)
- Leruez-Ville M, "Accuracy of prenatal ultrasound screening to identify fetuses infected by cytomegalovirus which will develop severe long-term sequelae", Ultrasound Obstet Gynecol, 57, pp.97~104 (2021)
- Leruez-Ville M, "Feasibility of predicting the outcome of fetal infection with cytomegalovirus at the time of prenatal diagnosis", Am J Obstet Gynecol, 215, pp.342.e1~342.e9 (2016)
- Leruez-Ville M, "Fetal cytomegalovirus infection", Best Pract Res Clin Obstet Gynaecol, 38, pp.97~107 (2017)
- Manicklal S, "The"silent"global burden of congenital cytomegalovirus", Clin Microbiol Rev, 26, pp.86~102 (2013)
- Navti OB, "Cytomegalovirus infection in pregnancy-an update", Eur J Obstet Gynecol Reprod Biol, 258, pp.216~222 (2021)
- Nigro G, "Passive immunization during pregnancy for congenital cytomegalovirus infection", N Engl J Med, 353, pp.1350~1362 (2005)
- Pass RF, "Mother-to-child transmission of cytomegalovirus and prevention of congenital infection", J Pediatric Infect Dis Soc, 3(Suppl 1), pp.S2~S6 (2014)
- Pass RF, "Congenital cytomegalovirus infection following first trimester maternal infection : symptoms at birth and outcome", J Clin Virol, 35, pp.216~220 (2006)
- Retzler J, "Economic cost of congenital CMV in the UK", Arch Dis Child, 104, pp.559~563 (2019)
- Revello MG, "A randomized trial of hyperimmune globulin to prevent congenital cytomegalovirus", N Engl J Med, 370, pp.1316~1326 (2014)
- Revello MG, "Prevention of primary cytomegalovirus infection in pregnancy", EBioMedicine, 2, pp.1205~1210 (2015)
- Schaefer MR, "Development and assessment of a prenatal cytomegalovirus(cmv)educational survey : implementation and impact in a metropolitan university-based clinic", Int J Womens Health, 12, pp.1205~1214 (2020)
- Society for Maternal-Fetal Medicine(SMFM), "Diagnosis and antenatal management of congenital cytomegalovirus infection", Am J Obstet Gynecol, 214, pp.B5~11 (2016)
- Xu H, "Intrauterine cytomegalovirus infection: a possible risk for cerebral palsy and related to its clinical features, neuroimaging findings: a retrospective study", BMC Pediatr, 20, pp.555~ (2020)
- Yinon Y, "No. 240-Cytomegalovirus infection in pregnancy", J Obstet Gynaecol Can, 40, pp.e134~41 (2018)
- Yinon Y, "Cytomegalovirus infection in pregnancy", J Obstet Gynaecol Can, 32, pp.348~354 (2010)
