몬테칼로 기법을 이용한 방사선 선량증가 물질에 따른 선량증가 효과 평가
A Monte Carlo Study of Dose Enhancement according to the Enhancement Agents
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초록
Monte Carlo 시뮬레이션을 이용하여 MV X, γ선에서의 선량증가 효과를 평가하였다. MCNPX code를 이용하여ICRU 평판형(Slab) 모의피폭체를 전산모사하였으며, 입사 광자의 에너지, 선량증가 물질의 종류 및 농도에 따른영향을 분석하였다. 선량증가 물질은 금(aurum), 가돌리늄(gadolinium), 요오드(iodine), 산화철(iron oxide)에 대해 비교 평가하였으며, 입사에너지는 선형가속기에서 발생된 4, 6, 10, 15 MV X선의 스펙트럼과 Co 60의 γ선원을사용하였다. 모의피폭체 내에 7, 18, 30 mg/g 농도의 물질을 삽입하였으며, 선량증가 효과의 정량적 평가를 위해선량증가비를 산출하였다. X선의 입사에너지가 낮을수록, 선량증가 물질의 농도가 높을수록 높은 선량증가비를 나타내었으며, 최대 선량증가비는 금 1.079, 가돌리늄 1.062, 요오드 1.049, 산화철 1.035를 보여 금, 가돌리늄, 요오드, 산화철 입자 순으로 높은 선량증가 효과를 보였다. 이러한 결과는 In-vivo, vitro 연구의 기초자료로 활용할 수있을 것으로 사료된다.
Abstract
Dose enhancement effects at megavoltage (MV) X and γ-ray energies, and the effects of different energy levels on incident energy, dose enhancement agents, and concentrations were analyzed using Monte Carlo simulations. Gold, gadolinium, Iodine, and iron oxide (Fe2O3) were compared as dose enhancement agents. For incident energy, 4, 6, 10 and 15 MV X-ray spectra produced by a linear accelerator and a Co60 γ-ray were used. The dose enhancement factor (DEF) was calculated using an ICRU Slab phantom for concentrations of 7, 18, and 30 mg/g. The DEF was higher at higher concentrations of dose enhancement agents and at lower incident energies. The calculated DEF ranged from 1.035 to 1.079, and dose enhancement effects were highest for iron oxide, followed by iodine, gadolinium, and gold. Thus, this study contributes to improving the therapeutic ratio by delivering larger doses of radiation to tumor volume, and provides data to support further in vivo and in vitro studies.
참고문헌 (29)
- Berbeco R, "In vitro dose enhancement from gold nanoparticles under different clinical MV photon beam configurations", Med Phys, 39(6), pp.3900~ (2012)
- Brun E, "Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution", Colloids Surf B, 72, pp.128~134 (2009)
- Butterworth KT, "Gold nanoparticles: from nanomedicine to nanosensing", Nanotechnol Sci Appl, 1, pp.45~66 (2008)
- Faiz M. Khan, "The physics of radiation therapy", Wolters Kluwer Lippincott Williams & Wilkins
- James F. Hainfeld, "Radiotherapy enhancement with gold nanoparticels", Journal of pharmacy and parmacology, 60, pp.977~985 (2008)
- John, "Complication probability as assessment from dose-volume histograms", Radiation Research, 104, pp.13~19 (1985)
- Perez-Lopez CE, "Monte Carlo modeling and optimization of contrast-enhanced radiotherapy of brain tumors", Phys Med Biol, 56, pp.4059~4072 (2011)
- Chithrani DB, "Gold nanoparticles as radiation sensitizers in cancer therapy", Radiat Res, 173, pp.719~728 (2010)
- Duc G, "Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticle", ACS nano, 5, pp.9566~9574 (2011)
- Ghorbani M., "Dose enhancement by various nanoparticles in prostate brachythreapy", Australas Phy Eng Sci Med, 36, pp.431~440 (2013)
- Zhang SX, "Quantifying tumor-selective radiation dose enhancements using GNPs: a Monte Carlo simulation study", Biomed Microdevices, 11(4), pp.925~933 (2009)
- Bahreyni Toossi MT, "A Monte Carlo study on tissue dose enhancement in brachytherapy: a comparison between gadolinium and gold nanoparticles", Australas Phys Eng Sci Med, 35, pp.177~185 (2012)
- Khoei S, "The role of iron oxide nanoparticles in the radiosensitization of human prostate carcinoma cell line DU145 at megavoltage radiation energies", Int J Radiat Biol, 90(5), pp.351~356 (2014)
- Corot C, "Superparamagnetic iron oxide nanoparticles for MRI: contrast media pharmaceutical company R&D perspective", Wiley Interdiscip Rev Nanomed Nanobiotechnol, 5, pp.411~422 (2013)
- 강상구, "몬테카를로 방법에 의한 6MV 선형가속기의 광자 흡수선량 분포 평가에 관한 연구", 방사선기술과학, 34(1), pp.43~50 (2011), 대한방사선과학회
- International Commission on Radiation Units and Measurements, "ICRU", ICRU, ~, pp.ICRU Report 37 (1984)
- Baumgartner A., "Simulation of photon energy spectra from Varian 2100C and 2300C", D Linacs: Simplified estimates with PENELOPE Monte Carlo models, 2009, pp.67, 2007~2012
- Asghar M, "Monte Carlo calculation of Varian 2300C", D Linac photon beam characteristics: a comparison between MCNP4C, GEANT3 and measurements, 2005, pp.62, 467~477
- Pelowitz D. B., "MCNPX user's manual 2.7.0. LANL Report LA-CP-11-00438", Los Alamos National Laboratory, ~ (2011)
- Mesbahi A, "Effect of photon beam energy, gold nanoparticle size and concentration on the dose enhancement in radiation therapy", BioImpacts, 3, pp.29~35 (2013)
- Delaram Pakravan, "Tumor dose enhancement by gold nanoparticles in a 6 MV photon beam: a Monte Carlo study on the size effect of nanoparticles", NUKLEONIKA, 58, pp.275~280 (2013)
- Mohammad Taghi Bahreyni Toossi, "A Monte Carlo study on dose enhancement and photon contamination production by various nanoparticles in electron mode of a medical linac", NUKLEONIKA, 60, pp.489~496 (2015)
- Ramesh N., "Dose enhancement in gold nanoparticle-aided radiotherapy for the therapeutic photon beams using Monte Carlo technique", Journal of Cancer Research and Therapeutics, 11, pp.94~97 (2011)
- Butterworth KT, "Radiosensitization by gold nanoparticles: effective at megavoltage energies and potential role of oxidative stress", Transl Cancer Res, 2, pp.269~279 (2013)
- Faiz M. Khan, "The physics of radiation therapy", Wolters Kluwer Lippincott Williams & Wilkins
- 황철환, "몬테칼로 기법을 이용한 금 나노입자에서의 2차 전자 발생 평가", 한국방사선학회논문지, 10(3), pp.153~159 (2016), 한국방사선학회[DOI]
- McMahon S., "Radiotherapy in the presence of contrast agents:a general figure of merit and its application to gold nanoparticle", Phys Med Biol, 53, pp.5635~5651 (2008)
- Daniel G, "Monte Carlo study of Radiation Dose Enhancement by Gadolinium in Megavoltage and High Dose Rate Radiotherapy", PLOSONE, 9, pp.1~7 (2014)
- Huang FK, "Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles", Phys Med Biol, 55, pp.469~482 (2010)