폐경 후 여성의 골밀도 수치와 지방조직과의 연관성
The Relationship Between Bone Mineral Density and Adipose Tissue of Postmenopausal Women
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폐경 후 여성에서 골다공증과 비만은 삶의 질적인 면에서 많은 영향을 미친다. 폐경 후 여성은 호르몬의 변화로 골다공증과 비만의 위험이 높아진다. 골다공증과 체중과의 관련성이 알려져 있고 특히 체지방량과의 관련성이 논의되고 있다. 본 연구에서는 폐경 후 여성에서 골밀도 수치에 따라 체지방 중 심장외막지방과 복부피하지방과 비교하여 골밀도 수치 변화가 지방조직과 관련이 있는지 알아보고자 하였다. 내과 및 검진센터를 방문한 폐경 후여성 중 골밀도검사와 심장초음파를 실시한 160명이 연구대상이었다. 심장외막지방두께는 세 단면의 측정값을 평균하였으며, 골밀도 수치는 L-spine과 대퇴골 경부의 T값을 사용하여 분석하였다. 및 골밀도검사는 진단기준에 맞게 측정하여 연구결과 나이가 증가할수록 골다공증의 위험이 높아지고 체중은 감소할수록 골다공증의 위험이 높아지는 것으로 나타났다(p<0.05). 폐경 후 여성에서 지방조직과 골밀도 수치변화의 연관성을 보기 위한 연구결과에서는 심장외막지방두께의 증가는 골밀도 수치에 음의 상관관계를 보였고(p<0.05), 복부피하지방두께의 증가는 골밀도 수치에 양의 상관관계가 있는 것으로 분석되었다(p<0.05). 즉 지방조직의 침착위치에 따라 골밀도 수치가 미치는 영향이 서로 다른 것으로 나타났다. 폐경기 여성에서 심장외막지방조직의 두께 변화를 정기적으로 검사한다면 골다공증을 미리 예방할 수 있을 것으로 생각된다.
Abstract
Postmenopausal women are at increased risk for osteoporosis and obesity due to changes in hormones. The relationship between osteoporosis and body weight is known, and its relation with body fat mass is discussed. The purpose of this study was to evaluate the bone mineral density(BMD) changes of epicardial adipose tissue(EAT) and abdominal subcutaneous fat. The subjects of this study were 160 postmenopausal women who underwent BMD and echocardiography. The thickness of the epicardial adipose tissue was measured in three sections and the BMD were meassured according to the diagnostic criteria. The results of this study that age increase the risk of osteoporosis increases, and as the weight and BMI decrease, the risk of osteoporosis increases(p<0.05). The relationship between changes in bone mineral density and adipose tissue in postmenopausal women, increased epicardial adipose tissue was negatively correlated with the bone mineral density(p<0.05). conversely, increased abdominal subcutaneous fat thickness was positively correlated with bone mineral density(p<0.05). In other words, the effect of bone mineral density on the location of adipose tissue was different. If Echocardiography is used to periodically examine changes in the thickness of the epicardial adipose tissue, it may be prevented before proceeding to osteoporosis.
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