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Significance of Hertwig’s Epithelial Root Sheath

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As tooth crown formation completes and root formation begins, the inner and outer enamel epithelial cells proliferate from the cervical loop of the enamel organ to form a continuous sheath containing double layer of cells, which is known as Hertwig's epithelial root sheath (HERS). Through reciprocal epithelial-mesenchymal interactions, HERS plays an important role in root development, including root morphogenesis (root size, shape and number), dentinogenesis and cemetogenesis. However, the precise nature of this role remains unclear. At later stage of root development, following the formation of first radicular mantle dentin, HERS fragments into discrete clusters of cells and migrate away from the root to the region of future periodontal ligament, which form the epithelia cell rests of Malassez (ERM).

Abstract

As tooth crown formation completes and root formation begins, the inner and outer enamel epithelial cells proliferate from the cervical loop of the enamel organ to form a continuous sheath containing double layer of cells, which is known as Hertwig's epithelial root sheath (HERS). Through reciprocal epithelial-mesenchymal interactions, HERS plays an important role in root development, including root morphogenesis (root size, shape and number), dentinogenesis and cemetogenesis. However, the precise nature of this role remains unclear. At later stage of root development, following the formation of first radicular mantle dentin, HERS fragments into discrete clusters of cells and migrate away from the root to the region of future periodontal ligament, which form the epithelia cell rests of Malassez (ERM).

참고문헌 (42)

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