Re-tested Parametric Multiple Testing Methods for Correlated Tests
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In clinical trials, multiple endpoints are often correlated. To control the family-wise type I error rate, Huque and Alosh’s flexible fixed-sequence (FFS) testing method and Li and Mehrotra’s adaptive alpha allocation approach (4A) have taken into account correlations among endpoints. I suggested a weighted multiple testing correction (WMTC) for correlated tests and compared it with FFS and 4A. The WMTC method is a re-tested method while the FFS and 4A methods are not. In this paper, we propose a re-tested FFS method and a re-tested 4A method. Simulations are conducted to compare them with the WMTC and the original FFS and 4A methods.
Abstract
In clinical trials, multiple endpoints are often correlated. To control the family-wise type I error rate, Huque and Alosh’s flexible fixed-sequence (FFS) testing method and Li and Mehrotra’s adaptive alpha allocation approach (4A) have taken into account correlations among endpoints. I suggested a weighted multiple testing correction (WMTC) for correlated tests and compared it with FFS and 4A. The WMTC method is a re-tested method while the FFS and 4A methods are not. In this paper, we propose a re-tested FFS method and a re-tested 4A method. Simulations are conducted to compare them with the WMTC and the original FFS and 4A methods.
참고문헌 (7)
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- Xie, C, "Weighted multiple testing correction for correlated tests", Stat Med, 31, pp.341~352 (2012)
- Changchun Xie, "Weighted Multiple Testing Correction for Correlated Binary Endpoints", Communications in Statistics - Simulation and Computation, pp.130102064240003~ (2013), Informa UK Limited[DOI]
- Changchun Xie, "Relations among three parametric multiple testing methods for correlated tests", Journal of Statistical Computation and Simulation, 84(4), pp.812~818 (2012), Informa UK Limited[DOI]
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