위 Helicobacter pylori 감염 및 중성구침윤과 장상피화생의 연관성

Abstract

Helicobacter pylori (H. pylori) infection is uncommon in developed countries, yet is commen in underdeveloped and developing countries. Infection rate if H. pylori is minimally influenced by economic, environmental, and public health status and genetic factors. Korea ia a developing country with a high incidence of H. pylori infection and gastric carcinoma, which is one of the leading causes of death. For this reason, accurate clinical and pathologic data on H. pylori-associated disease are very important. International metaplasia accompanies chronic gastritis and increases the risk of gastric carcinoma. For this reason, the relationship betweem H. pylori infection and intestinal metaplasia is very closely linked. Because of this, as the antecedent condition is guessed, it examines the relationship of the H. pylori and the intestinal metaplasia. Intestinal metaplasia is thought to be the basis un the development of intestinal type gastric carcinomas. Recent investigations showed that inflammatory reaction in the gastric carcinogenesis. To verify neutrophilic activity in the gastric fundus and development of intestinal metaplasia in both gastric fundus and antral mucosa, their relationship was studied using 159 healthy patients who had undergone gastric endoscopic biopsies without any identifiable pathologic diseases. When neutrophilic activity accompanied, incidence of intestinal metaplasia was signficantly increases (p<0.05). H. pylori infection was statistically and signficantly with the presence of intestinal metaplasia (P<0.05). These results suggest that H. pylori infection affected the development of interstinal metaplasia in the stomach. These results will help our understanding of H. pylori infection in the pathogenesis of intestinal metaplasia, a preneopastic condition of the stomach. To reduce the gastric adenocarcinoma, eradication treatment of H. pylori is recommended when there's neutrophilic activity in the gastric fudus.