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한국 성인남성에서 Lipid Accumulation Product 지수와 Alanine Aminotransferase와의 관련성

Relationship between the Lipid Accumulation Product Index and Alanine Aminotransferase in Korean Adult Men

신경아
대한임상검사과학회 (Korean Society for Clinical Laboratory Science)|2017.12|대한임상검사과학회지 (Korean Journal of Clinical Laboratory Science)|제49권 제4호|pp. 374-381|DOI 10.15324/kjcls.2017.49.4.374

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키워드

Non-alcoholic fatty liver diseaseAlanine aminotransferaseLipid accumulation product
주제분류기타자연과학

초록

LAP 지수는 공복시 중성지방 농도와 허리둘레의 조합으로 과도한 지방축적을 평가하는 지표이다. 이 연구는 LAP 지수와 ALT간의 관련성과 LAP 지수가 ALT에 미치는 영향에 대해 알아보고자 간질환의 병력이 없는 건강한 성인남성을 대상으로 횡단면 연구를 실시하였다. 2015년 1월부터 2017년 6월까지 경기지역 종합병원에서 건강검진을 시행한 20세 이상 70세 이하의 성인 남성 13,854명을 연구 대상자로 하였다. LAP 지수는 남성의 경우 [허리둘레(cm)-65]×[중성지방(mmol/L)]으로 산출하였으며, 혈청 ALT 농도의 이상치는 남성 40 IU/L 이상인 경우를 기준으로 설정하였다. 모든 대상자들은 인체측정학적 지표와 생리학적 검사를 실시하였다. LAP 분위수가 증가할수록 ALT는 통계적으로 유의한 증가를 보였다(p＜0.001). LAP 지수는 ALT 와 상관관계를 보였으며(r=0.238, p＜0.001), 특히 인슐린(r=0.449, p＜0.001) 및 HDL-콜레스테롤(r=−0.369, p＜0.001) 과 상관성이 높게 나타났다. 또한 LAP 지수는 ALT에 영향을 미치는 요인이었으며(p＜0.001), LAP 지수가 높을수록 ALT가 상승할 위험이 높게 나타났다(p＜0.001). 결론적으로 LAP 지수는 한국 성인남성에서 ALT 상승을 예측하는 지표로 나타났다.

Abstract

The LAP (lipid accumulation product) index is an indicator of excessive fat accumulation in combination with the fasting triglyceride concentration and waist circumference. This study examined the relationship between the LAP index and ALT (alanine aminotransferase) level and the effect of the LAP index on the ALT level. Cross-sectional studies were conducted on healthy adult males without a history of liver disease. From January 2015 to June 2017, 13,854 adults between 20 and 70 years of age, who underwent health screening at a general hospital in Gyeonggi-do, were enrolled in this study. The LAP index was calculated as [waist circumference (cm)− 65]×[triglyceride (mmol/L)] for males. Serum ALT abnormalities were set at 40 IU/L or more in males. All subjects underwent measurements of the anthropometric indicators and physiological examinations. A significant increase in ALT with increasing LAP quintiles was observed (p ＜0.001). The LAP index correlated with ALT (r=0.238, p＜0.001). Insulin (r=0.449, p＜0.001) and HDL-cholesterol (r=−0.369, p＜0.001) were strongly correlated with LAP. In addition, the LAP index is a factor affecting the ALT level (p＜0.001). As the LAP index increased, the risk of an elevated ALT was higher (p＜0.001). In conclusion, the LAP index was a predictor of an ALT elevation in Korean men.

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