Apolipoprotein E 유전자형과 알츠하이머형 치매의 통계적인 고찰

Abstract

Apolipoprotein E is the major lipid-carrier protein in the brain, and several studies provided evidence that apolipoprotein E(ApoE) epsilon4 allele can be considered a genetic risk factor for Alzheimer's disease(AD). Inheritance of the APOE gene has three alleles: ε2, ε3 and ε4. There are six possible genotypes: ε2/ε2, ε3/ε 3, ε4/ε4, ε2/ε3, ε2/ε4, ε3/ε4. AD is characterized by a progressive loss of function and death of nerve cells in several areas of the brain. The ε4 allele is associated with a risk for developing AD. People with the ε4/ε4 genotype have the highest risk, but people with the ε2/ε4 or ε3/ε4 genotypes are also likely to develop the disease. 64.3% of people carry the is ε3/ε3 genotype, 22.1% carry the second ε3/ε4 genotype but, ε2/ε2 genotype is not usually found of people carry the 3.6% is ε4/ε4 genotype in a total of a test group of 140 people. The ratio of ε4/ε4 genotype related directly with AD is less than the ε3/ε3 genotype, but the ε2/ε4 and ε3/ε4 genotype ratio of indirect AD risk is 25.7% in the group of people, regardless. Thus, we have referred to the benefit from the treatment of AD through apoE genotype diagnosis.