A Study on the Relationship between CBC and EEG for Epilepsy Patients
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Epilepsy is a disorder that causes recurring seizures, and the most objective and useful test for detecting epilepsy is the electroencephalogram (EEG). The subjects of this study are 244 patients who received an EEG after being diagnosed with epilepsy at Seoul National University Hospital in 2014, and who have agreed to the purpose of the study. Based on the EEG results, subjects were divided into normal and abnormal groups with 122 subjects in each group, regardless of their gender and age, to investigate the correlation of EEG and complete blood cell count (CBC) test results. The four significant categories that displayed significant correlation between EEG results and CBC hematological measurements in this study were the white blood cell (WBC), red blood cell (RBC), neutrophil, and lymphocyte tests. The WBC (p＜0.05) and neutrophil (p＜0.01) showed a positive correlation with EEG results, while RBC (p＜0.05) and lymphocyte (p＜0.01) showed a negative correlation. One of the limitations of this study is that it is lacking the blood test result analysis according to the types of anti-epilepsy medicine. However, the analysis of EEG results by the same disease has significant meaning. Therefore, further studies are needed to statistically analyze more data in the future.
Abstract
Epilepsy is a disorder that causes recurring seizures, and the most objective and useful test for detecting epilepsy is the electroencephalogram (EEG). The subjects of this study are 244 patients who received an EEG after being diagnosed with epilepsy at Seoul National University Hospital in 2014, and who have agreed to the purpose of the study. Based on the EEG results, subjects were divided into normal and abnormal groups with 122 subjects in each group, regardless of their gender and age, to investigate the correlation of EEG and complete blood cell count (CBC) test results. The four significant categories that displayed significant correlation between EEG results and CBC hematological measurements in this study were the white blood cell (WBC), red blood cell (RBC), neutrophil, and lymphocyte tests. The WBC (p＜0.05) and neutrophil (p＜0.01) showed a positive correlation with EEG results, while RBC (p＜0.05) and lymphocyte (p＜0.01) showed a negative correlation. One of the limitations of this study is that it is lacking the blood test result analysis according to the types of anti-epilepsy medicine. However, the analysis of EEG results by the same disease has significant meaning. Therefore, further studies are needed to statistically analyze more data in the future.
참고문헌 (15)
- Annegers JF, "Risk of recurrence after an initial unprovoked seizure", Epilepsia, 27, pp.43~50 (1986)
- Askamp J, "Diagnostic decision-making after a first and recurrent seizure in adults", Seizure, 22, pp.507~511 (2013)
- Ettinger AB, "Positive and negative psychotropic effects of lamotrigine in patients with epilepsy and mental retardation", Epilepsia, 39, pp.874~877 (1998)
- Hauser WA, "Seizure recurrence after a 1st unprovoked seizure: an extended follow-up", Neurology, 40, pp.1163~1170 (1990)
- Kim H, "Clinical and EEG risk factors for subsequent epilepsy in patients with complex febrile seizures", Epilepsia Res, 105, pp.158~163 (2013)
- Noachtar S, "The role of EEG in epilepsy: a critical review", Epilepsy Behav, 15, pp.22~33 (2009)
- 박수철, "간질 치료에서 뇌파의 임상적 유용성에 관한 논란: 긍정과 부정적 관점에서", 대한임상신경생리학회, 9(2), pp.59~62 (2007), 대한임상신경생리학회
- Pearce KM, "An audit of electroencephalography requests:use and misuse", Seizure, 15, pp.184~189 (2006)
- Pillai J, "Interictal EEG and the diagnosis of epilepsy", Epilepsia, 47, pp.14~22 (2006)
- Shinnar S, "Risk of seizure recurrence following a first unprovoked seizure in childhood: a prospective study", Pediatrics, 85, pp.1076~1085 (1990)
- Son YR, "Oxcarbazepine induced leukopenia.", J Korean Epilepsy Soc, 17, pp.22~23 (2013)
- Shorvon SD, "The etiologic classification of epilepsy", Epilepsia, 52, pp.1052~1057 (2011)
- van Donselaar CA, "Value of the electroencephalogram in adult patients with untreated idiopathic first seizures", Arch Neurol, 49, pp.231~237 (1992)
- Theodore WH, "Serial EEG in intractable epilepsy", Neurology, 34, pp.863~867 (1984)
- Yu J., "Hormone changes in epilepsy and effects of hormones on seizure or cortical excitability", J Korean Epilepsy Soc, 12(1), pp.11~21 (2008)