The Anti-Inflammatory Effects of Picea wilsonii Mast on HaCaT Cells
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Atopic dermatitis refers to a chronic, recurrent, skin condition, typically typified by itching, inflamed skin. It precedes other allergic diseases, such as asthma, food allergies, and allergic rhinitis, and is usually accompanied by various other immune disorders and secondary symptoms. In this study, we discovered that when treating TNF-α and IFN-γ-stimulated HaCaT cells with various concentrations of Picea wilsonii Mast (PwM) extracts, the cell viability was excellent. In addition, we measured the inflammatory cytokines associated with atopic dermatitis, including IL-6, IL-8, IL-13, and MCP-1. The production of IL-6, IL-13, and MCP-1 decreased in the presence of PwM extracts, whereas there was no significant difference in the production of IL-8. Further studies are necessary to develop an effective cure for atopic dermatitis and inflammation using foreign plant extracts, and PwM efficacy should be determined with an in-depth, objective verification process using protein and mechanism analysis.
Abstract
Atopic dermatitis refers to a chronic, recurrent, skin condition, typically typified by itching, inflamed skin. It precedes other allergic diseases, such as asthma, food allergies, and allergic rhinitis, and is usually accompanied by various other immune disorders and secondary symptoms. In this study, we discovered that when treating TNF-α and IFN-γ-stimulated HaCaT cells with various concentrations of Picea wilsonii Mast (PwM) extracts, the cell viability was excellent. In addition, we measured the inflammatory cytokines associated with atopic dermatitis, including IL-6, IL-8, IL-13, and MCP-1. The production of IL-6, IL-13, and MCP-1 decreased in the presence of PwM extracts, whereas there was no significant difference in the production of IL-8. Further studies are necessary to develop an effective cure for atopic dermatitis and inflammation using foreign plant extracts, and PwM efficacy should be determined with an in-depth, objective verification process using protein and mechanism analysis.
참고문헌 (29)
- Leung DY, "Atopic dermatitis", Lancet, 361, pp.150~160 (2003)
- 유정석, "Prevalence of Atopic Dermatitis in Korea: Analysis by Using National Statistics", Journal of Korean Medical Science, 27(6), pp.681~685 (2012), 대한의학회[DOI]
- Sturgil S, "Atopic dermatitis update", Curr Opin Pediatr, 16, pp.396~401 (2004)
- Ozakaya E, "Adult-onset atopic dermatitis", J Am Acad Dermatol, 52, pp.579~582 (2005)
- Ou LS, "Advances in atopic dermatitis", Chang Gung Med J, 28(1), pp.1~8 (2005)
- Novak N, "Immune mechanisms leading to atopic dermatitis", J Allergy Clin Immunol, 112(6), pp.128~139 (2003)
- Hamid Q, "Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis", J Clin Invest, 94(2), pp.870~876 (1994)
- Ono SJ, "Chemokines : roles in leukocyte development, trafficking, and effector function", J Allergy Clin Immunol, 111(6), pp.1185~1199 (2003)
- Farjon A, "A handbook of the world's conifers" (2010), Koninklijke Brill
- Eckenwalder JE, "Conifers of the world: The complete reference" (2009), Timber
- Holgate ST, "Treatment strategies for allergy and asthma", Nat Rev Immunol, 8, pp.872~892 (2008)
- Palmer CN, "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis", Nat Genet, 38, pp.441~446 (2006)
- Elias PM, ""Outside-to-inside"(and now back to"outside")pathogenic mechanisms in atopic dermatitis", J Invest Dermatol, 128, pp.1067~1070 (2008)
- Roitt M, "Immunology", pp.119~128 (2002), Mosby
- 양희태, "아토피 피부염 환자에서 기능성 한방 추출액의 임상 효과", 한국식품영양학회지, 18(4), pp.380~384 (2005), 한국식품영양학회
- 박영숙, "황금열수추출물이 DNCB로 유도된 알레르기성 접촉피부염 흰쥐의 항산화능 및 표피회복능에 미치는 영향", 한국식품영양과학회지, 35(6), pp.543~548 (2006), 한국식품영양과학회
- 남상해, "두충 추출물이 DNCB로 유발된 알레르기성 접촉피부염과 산화적 손상에 미치는 영향", 한국식품영양과학회지, 36(12), pp.1517~1522 (2007), 한국식품영양과학회
- 김길수, "Effects of Opuntia humifusa Extract on DNCB-Induced Allergic Contact Dermatitis in BALB", c Mice, 2007, pp.23(2), 169~173[DOI]
- 이인회, "김치 추출 프로바이오틱스 섭취가 아토피 동물모델 NC", Nga mice에서면역 지표에 미치는 영향, 2008, pp.40(1), 82~87[DOI]
- 김민아, "신선초 추출물의 아토피 억제활성", 한국식품저장유통학회지, 19(5), pp.792~798 (2012), 한국식품저장유통학회
- Church MK, "The human mast cell", J Allergy Clin Immunol, 99(2), pp.155~160 (1997)
- Metcalfe DD, "Mast cells", Physiol Rev, 77(4), pp.1033~1079 (1997)
- Deshmane SL, "Monocyte chemoattractant protein-1(MCP-1) : an overview", J Interferon Cytokine Res, 29(6), pp.313~326 (2009)
- Rabia Hussain, "CCL2", MCP-I Genotype-Phenotype Relationship in Latent Tuberculosis Infection, 2011, pp.6(10), e25803~[DOI]
- Santos JC, "Up-regulation of chemokine C-C ligand 2(CCL2)and C-X-C chemokine 8(CXCL8)expression by monocytes in chronic idiopathic urticaria", Clin Exp Immunol, 167(1), pp.129~136 (2012)
- 백영미, "구판의 LPS로 유도된 염증 반응 억제 효과", 동의생리병리학회지, 26(1), pp.26~34 (2012), 한의병리학회
- Simon D, "The interleukin-13 production by peripheral blood T cells from atopic dermatitis patients does not require CD2 costimulation", Int Arch Allergy Immunol, 132(2), pp.148~155 (2003)
- Holgate ST, "Treatment strategies for allergy and asthma", Nat Rev Immunol, 8, pp.872~892 (2008)
- Yang EJ, "Inhibitory effects of Duchesnea chrysantha extract on ovalbumin-induced lung inflammation in a mouse model of asthma", J Ethnopharmacol, 118(1), pp.102~107 (2008)