당뇨병이 없는 비만 성인의 hs-CRP 수준과 FBG, Fructosamine 및 HbA1c와의 관련성
Relationship of the hs-CRP Levels with FBG, Fructosamine, and HbA1c in Non-diabetic Obesity Adults
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본 연구는 국민건강영양조사 자료를 이용하여 당뇨병이 없는 성인 4,734명을 대상으로 비만 성인의 hs-CRP와 혈당조절지표들과의 관련성에 대해 알아보고자 하였다. 연구결과 BMI 가 증가할수록 혈당조절지표인 FBG와 fructosamine 및HbA1c가 증가하였으며, hs-CRP는 비만 군에서 가장 높은 수치를 보였고, 인슐린저항성의 지표인 HOMA-IR도 비만 군에서통계적으로 유의하게 증가하였다. 또한 hs-CRP 수준을 구분하여 혈당조절지표들과의 관련성을 확인한 결과 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA1c가 증가됨을 확인하였고, 여러 관련 변수를 보정한 후에도 hs-CRP가 증가할수록 FBG, fructosamine 및 HbA1c가 통계적으로 유의하게 증가하였다. 결과적으로 비만과 hs-CRP, 혈당조절지표는 각각에서 연관성을 보여 당뇨병이 없는 성인 중 높은 BMI에서 증가된 hs-CRP에의해 당뇨병의 주요한 병인인 인슐린 저항성을 증가시켜 혈당조절지표인 FBG, fructosamine 및 HbA1c가 통계적으로 유의하게 증가한 것으로 사료된다. 이에 당뇨병이 없는 성인에서도올바른 식습관 및 규칙적인 운동으로 비만을 예방하여 당뇨병발생을 감소시키는 노력이 강구되어야 하겠다.
Abstract
Obesity has been reported to be a cluster of risk factors in the pathological ecology, In particular, there is increasing evidence that inflammation-related factors are associated with diabetes. This study examined the relationship between the hs-CRP level and FBG, fructosamine, and HbA1c in 4,734 non-diabetic adults aged 20 years or older, who were approved by the National Health and Nutrition Survey in 2015. The results showed that the FBG, fructosamine, and HbA1c levels increased with increasing BMI; the hs-CRP levels were the highest in the obese group, and HOMA-IR, an index of insulin resistance, was also significantly higher in the obese group. The hs-CRP level was the highest in obese adults. The levels of FBG, fructosamine. and HbA1c, which are involved in blood glucose control, increased with increasing hs-CRP level. The FBG, fructosamine, and HbA1c levels increased significantly with increasing hs-CRP level after adjusting for various related variables. These results suggest that the obesity-induced increase in hs-CRP is a risk factor for diabetes mellitus in non-diabetic adults. Therefore, proper dietary habits and regular exercise should prevent diabetes by preventing obesity in non-diabetic adults.
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