폐광지역에서 생산된 백미 중 비소오염도와 확률론적 기법을 이용한 인체 위해성 평가
Arsenic Contamination of Polished Rice Produced in Abandoned Mine Areas and Its Potential Human Risk Assessment using Probabilistic Techniques
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초록
BACKGROUND: This study was conducted to investigate the arsenic (As) contaminations in polished rice cultivated nearby abandoned mine areas, and to estimate the potential health risk through dietary intake of As-enriched polished rice in each age-gender population. METHODS AND RESULTS: The As contents in polished rice grown fifteen abandoned mine areas were analyzed. The average daily intake (ADD) as well as probabilistic health risk were estimated by assuming probability distribution of exposure parameters. The average total As concentration in polished rice was 0.09±0.06 mg/kg with a range of 0.02~0.35 mg/kg. For health risk assessment, the ADD values in all age-gender populations did not exceed the provisional tolerable daily intake (PTDI) of 2.1 µg/kg b.w./day for inorganic As. Cancer risk probability (R) values were 2.45~3.28×10^(-4) and 2.51~5.75×10^(-4) for all age population and gender population, respectively. Particularly, the R value, 5.75×10^(-4) , for children less than six years old were estimated to be high. Hazard quotient (HQ) values were 0.23~0.31 and 0.11~0.33 for general population and age-gender population, respectively. CONCLUSION(s): The average R values assessed via intake of polished rice cultivated in abandoned mine areas exceeded the acceptable cancer risk of 10^(-6)~10^(-4) for regulatory purpose. Considering the HQ values smaller than 1.0, potential non-cancer toxic effects may not be caused by the long-time exposure through intake of As-contaminated polished rice.
Abstract
BACKGROUND: This study was conducted to investigate the arsenic (As) contaminations in polished rice cultivated nearby abandoned mine areas, and to estimate the potential health risk through dietary intake of As-enriched polished rice in each age-gender population. METHODS AND RESULTS: The As contents in polished rice grown fifteen abandoned mine areas were analyzed. The average daily intake (ADD) as well as probabilistic health risk were estimated by assuming probability distribution of exposure parameters. The average total As concentration in polished rice was 0.09±0.06 mg/kg with a range of 0.02~0.35 mg/kg. For health risk assessment, the ADD values in all age-gender populations did not exceed the provisional tolerable daily intake (PTDI) of 2.1 µg/kg b.w./day for inorganic As. Cancer risk probability (R) values were 2.45~3.28×10^(-4) and 2.51~5.75×10^(-4) for all age population and gender population, respectively. Particularly, the R value, 5.75×10^(-4) , for children less than six years old were estimated to be high. Hazard quotient (HQ) values were 0.23~0.31 and 0.11~0.33 for general population and age-gender population, respectively. CONCLUSION(s): The average R values assessed via intake of polished rice cultivated in abandoned mine areas exceeded the acceptable cancer risk of 10^(-6)~10^(-4) for regulatory purpose. Considering the HQ values smaller than 1.0, potential non-cancer toxic effects may not be caused by the long-time exposure through intake of As-contaminated polished rice.
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