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다양한 형태의 니코틴 중독사: 3예 보고

Various Forms of Fatal Nicotine Intoxications: Three Cases Report

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초록

Recently, fatal nicotine intoxications with electronic cigarette liquid have increased in Korea, but various kinds of cigarettes and smoking cessation aids may also cause fatal poisoning. We report cases of fatal nicotine intoxications involving causes other than the use of liquid nicotine. A 29-year-old woman (case 1) found dead in a hotel room with about 70 patches (21 mg dose) of nicotine on her body. Blood nicotine levels were 7.68 mg/L (heart) and 3.25 mg/L (femoral). A toxic level of zolpidem was also detected. A 28-year-old Uzbekistan man (case 2) was found dead in his uncle’s room with his face covered with chewing tobacco. Blood nicotine levels were 7.3 mg/L (heart) and 4.6 mg/L (femoral). Blood alcohol level was 0.139%. A 55-year-old man (case 3) bit his tongue. As he was taken to the hospital, his wife put tobacco powders in his mouth for hemostasis, and he died of cardiac arrest. Blood nicotine levels were 2.01 mg/L (heart) and 0.96 mg/L (femoral). Nicotine-related deaths can be caused by various types of administration including transdermal and transmucosal routes, and relatively small doses may cause death, so meticulous investigation should be taken when such deaths are suspected.

Abstract

Recently, fatal nicotine intoxications with electronic cigarette liquid have increased in Korea, but various kinds of cigarettes and smoking cessation aids may also cause fatal poisoning. We report cases of fatal nicotine intoxications involving causes other than the use of liquid nicotine. A 29-year-old woman (case 1) found dead in a hotel room with about 70 patches (21 mg dose) of nicotine on her body. Blood nicotine levels were 7.68 mg/L (heart) and 3.25 mg/L (femoral). A toxic level of zolpidem was also detected. A 28-year-old Uzbekistan man (case 2) was found dead in his uncle’s room with his face covered with chewing tobacco. Blood nicotine levels were 7.3 mg/L (heart) and 4.6 mg/L (femoral). Blood alcohol level was 0.139%. A 55-year-old man (case 3) bit his tongue. As he was taken to the hospital, his wife put tobacco powders in his mouth for hemostasis, and he died of cardiac arrest. Blood nicotine levels were 2.01 mg/L (heart) and 0.96 mg/L (femoral). Nicotine-related deaths can be caused by various types of administration including transdermal and transmucosal routes, and relatively small doses may cause death, so meticulous investigation should be taken when such deaths are suspected.

참고문헌 (9)

  1. 준영진, "Suicidal Death by Nicotine Poisoning", 대한법의학회지, 38(4), pp.167~170 (2014), 대한법의학회
  2. Yildiz D, "Nicotine, its metabolism and an overview of its biological effects", Toxicon, 43, pp.619~632 (2004)[DOI]
  3. Bannon YB, "Transdermal delivery of nicotine in normal human volunteers: a single dose and multiple dose study", Eur J Clin Pharmacol, 37, pp.285~290 (1989)[DOI]
  4. Gupta SK, "Bioavailability and absorption kinetics of nicotine following application of a transdermal system", Br J Clin Pharmacol, 36, pp.221~227 (1993)[DOI]
  5. Kemp PM, "Postmortem distribution of nicotine and cotinine from a case involving the simultaneous administration of multiple nicotine transdermal systems", J Anal Toxicol, 21, pp.310~313 (1997)[DOI]
  6. Solarino B, "Multidrug poisoning involving nicotine and tramadol", Forensic Sci Int, 194, pp.e17~e19 (2010)[DOI]
  7. Sanchez P, "Nicotine poisoning as a cause of cardiac arrest?", J Toxicol Clin Toxicol, 34, pp.475~476 (1996)[DOI]
  8. Lardi C, "Complex suicide with homemade nicotine patches", Forensic Sci Int, 236, pp.e14~e18 (2014)[DOI]
  9. Mayer B, "How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century", Arch Toxicol, 88, pp.5~7 (2014)[DOI]

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