Death from 2,4-Dinitrophenol Poisoning: An Autopsy Case
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
DNP (2,4-dinitrophenol) has been commonly used as a weight loss aid; in particular, it has been used by body builders to achieve significant fat loss while maintaining muscle mass. The sale of DNP was banned due to some cases of fatal poisoning. We describe an autopsy case of a 39-year-old man who died from taking DNP to treat obesity. He was 183 cm tall and weighed 101 kg (body mass index of 31). External examination did not reveal any specific findings implicating the cause of death. Gross examination revealed that the heart weight was 450 g, and there were no significant findings in the coronary arteries and myocardium, except for a few petechiae of the epicardium. The DNP concentration in the subject’s blood was 38.28 mg/L. According to references, a DNP blood concentration of 28 mg/L or higher would result in death. Therefore, the cause of death in this autopsy case was DNP toxicity.
Abstract
DNP (2,4-dinitrophenol) has been commonly used as a weight loss aid; in particular, it has been used by body builders to achieve significant fat loss while maintaining muscle mass. The sale of DNP was banned due to some cases of fatal poisoning. We describe an autopsy case of a 39-year-old man who died from taking DNP to treat obesity. He was 183 cm tall and weighed 101 kg (body mass index of 31). External examination did not reveal any specific findings implicating the cause of death. Gross examination revealed that the heart weight was 450 g, and there were no significant findings in the coronary arteries and myocardium, except for a few petechiae of the epicardium. The DNP concentration in the subject’s blood was 38.28 mg/L. According to references, a DNP blood concentration of 28 mg/L or higher would result in death. Therefore, the cause of death in this autopsy case was DNP toxicity.
참고문헌 (9)
- Siegmueller C, "Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you", Emerg Med J, 27, pp.639~640 (2010)
- Grundlingh J, "2,4-dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death", J Med Toxicol, 7, pp.205~212 (2011)
- Yen M, "Toxicity of weight loss agents", J Med Toxicol, 8, pp.145~152 (2012)
- Maragos WF, "Mitochondrial uncoupling as a potential therapeutic target in acute central nervous system injury", J Neurochem, 91, pp.257~262 (2004)
- Tewari A, "Weight loss and 2,4-dinitrophenol poisoning", Br J Anaesth, 102, pp.566~567 (2009)
- Geraldo de Campos E, "Analysis of 2,4-dinitrophenol in postmortem blood and urine by gas chromatography-mass spectrometry: method development and validation and report of three fatalities in the United States", J Forensic Sci, 65, pp.183~188 (2020)
- Holborow A, "Beware the yellow slimming pill: fatal 2,4-dinitrophenol overdose", BMJ Case Rep, 2016, pp.bcr2016214~ (2016)
- Lu YQ, "Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning", J Zhejiang Univ Sci B, 12, pp.189~192 (2011)
- Miranda EJ, "Two deaths attributed to the use of 2,4-dinitrophenol", J Anal Toxicol, 30, pp.219~222 (2006)