Maternal Death Due to Lymphocytic Hypophysitis: A Case Report
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Lymphocytic hypophysitis is a rare condition characterized by lymphocyte and plasma cell infiltration, leading to fibrosis and functional impairment of the pituitary gland. Although lymphocytic hypophysitis is associated with pregnancy, its diagnosis may be challenging in pregnant women owing to unclear symptoms of pituitary dysfunction. Lymphocytic hypophysitis can lead to serious complications, including a sudden death; however, no case of maternal death has been reported in Korea. This study presents a case of maternal death after childbirth. The deceased had a history of hypertension, obesity, hypothyroidism, and gestational diabetes and died suddenly the day after the emergency cesarean section. Notably, no other pregnancy-related complications were observed. Histopathological examination of the pituitary gland confirmed lymphocytic hypophysitis. This case report emphasizes the requirement of clinical awareness and underscores the significance of examining the pituitary gland during autopsy investigations of maternal deaths.
Abstract
Lymphocytic hypophysitis is a rare condition characterized by lymphocyte and plasma cell infiltration, leading to fibrosis and functional impairment of the pituitary gland. Although lymphocytic hypophysitis is associated with pregnancy, its diagnosis may be challenging in pregnant women owing to unclear symptoms of pituitary dysfunction. Lymphocytic hypophysitis can lead to serious complications, including a sudden death; however, no case of maternal death has been reported in Korea. This study presents a case of maternal death after childbirth. The deceased had a history of hypertension, obesity, hypothyroidism, and gestational diabetes and died suddenly the day after the emergency cesarean section. Notably, no other pregnancy-related complications were observed. Histopathological examination of the pituitary gland confirmed lymphocytic hypophysitis. This case report emphasizes the requirement of clinical awareness and underscores the significance of examining the pituitary gland during autopsy investigations of maternal deaths.
참고문헌 (10)
- Molitch ME, "Lymphocytic hypophysitis", Horm Res, 68(Suppl 5), pp.145~150 (2007)
- Joshi MN, "Mechanisms in endocrinology : hypophysitis : diagnosis and treatment", Eur J Endocrinol, 179, pp.R151~R163 (2018)
- Chang LS, "Endocrine toxicity of cancer immunotherapy targeting immune checkpoints", Endocr Rev, 40, pp.17~65 (2019)
- Gonzalez-Cuyar LF, "Sudden unexpected death in lymphocytic hypophysitis", Am J Forensic Med Pathol, 30, pp.61~63 (2009)
- Hashimoto K, "Lymphocytic adenohypophysitis and lymphocytic infundibuloneurohypophysitis", Endocr J, 44, pp.1~10 (1997)
- Rumana M, "Lymphocytic hypophysitis with normal pituitary function mimicking a pituitary adenoma : a case report and review of literature", Clin Neuropathol, 29, pp.26~31 (2010)
- Honegger J, "Diagnosis of primary hypophysitis in Germany", J Clin Endocrinol Metab, 100, pp.3841~3849 (2015)
- Blisard KS, "Sudden death due to lymphoplasmacytic hypophysitis", Am J Forensic Med Pathol, 13, pp.207~210 (1992)
- Chiloiro S, "The changing clinical spectrum of hypophysitis", Trends Endocrinol Metab, 30, pp.590~602 (2019)
- Zhang J, "Extremely dangerous hypopituitarism related long QT syndrome and transient STsegment elevation : a case report", SAGE Open Med Case Rep, 11, pp.2050313X221147194~ (2023)