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황금, 황련, 황백 및 어성초 추출물을 함유한 피부 개선 화장품 조성물

Functional cosmetic composition containing extracts of Scutellariae radix, Coptidis rhizoma, Phellodendron amurense and Houttuynia cordata

이선미|박규열
한국화장품미용학회 (The Korean Society of Cosmetics and Cosmetology)|2017.12|한국화장품미용학회지 (Korean Society of Cosmetics and Cosmetology)|제7권 제2호|pp. 249-258

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Houttuynia cordataCoptidis rhizomaScutellariae radixPhellodendron amurense
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초록

In our modern society, high level of economic growth and extension of human lifespan have led people to make efforts to maintain their health and be concerned about beautiful and healthy skin. Although various types of cosmetics are being developed and released to satisfy these customers needs, use of essential additives such as emulsifiers and preservatives seems inevitable, considering that the cosmetics are produced through physico-chemical processing of various chemical components and fragrances. Since dangers of these additives have begun to be proved, the maximum permissible amount of them is specified. Nevertheless, the general standards for the hazardous components can still lead expression of symptoms or aggravation of the diseases in sensitive skin or skin diseases. Therefore, it is important to develop the products with safety and effectiveness for continuous use and the symptom relief. Natural herbs used in oriental medicine have a high value as the cosmetic materials, as their excellent benefits such as antiseptic or antimicrobial properties have been reported in several industrial fields including cosmetics and foods, as well as their positive image. In this study, we have examined antioxidative effect of water and ethanol extracts of four natural herbs, Scutellariae radix, Coptidis rhizoma, Phellodendron amurense, and Houttuynia cordata. They all showed a significant antioxidative effect in a dose-dependent manner, and it suggested their potential as the functional ingredients that protect the skin cells from oxidative stress. We expect that further investigation on their anti-inflammatory and anti-microbial effect will provide a strong possibility that they could be used as the active ingredients of functional herbal cosmetics to improve atopic dermatitis.

Abstract

In our modern society, high level of economic growth and extension of human lifespan have led people to make efforts to maintain their health and be concerned about beautiful and healthy skin. Although various types of cosmetics are being developed and released to satisfy these customers needs, use of essential additives such as emulsifiers and preservatives seems inevitable, considering that the cosmetics are produced through physico-chemical processing of various chemical components and fragrances. Since dangers of these additives have begun to be proved, the maximum permissible amount of them is specified. Nevertheless, the general standards for the hazardous components can still lead expression of symptoms or aggravation of the diseases in sensitive skin or skin diseases. Therefore, it is important to develop the products with safety and effectiveness for continuous use and the symptom relief. Natural herbs used in oriental medicine have a high value as the cosmetic materials, as their excellent benefits such as antiseptic or antimicrobial properties have been reported in several industrial fields including cosmetics and foods, as well as their positive image. In this study, we have examined antioxidative effect of water and ethanol extracts of four natural herbs, Scutellariae radix, Coptidis rhizoma, Phellodendron amurense, and Houttuynia cordata. They all showed a significant antioxidative effect in a dose-dependent manner, and it suggested their potential as the functional ingredients that protect the skin cells from oxidative stress. We expect that further investigation on their anti-inflammatory and anti-microbial effect will provide a strong possibility that they could be used as the active ingredients of functional herbal cosmetics to improve atopic dermatitis.

참고문헌 (47)

  1. 오재원, "1995년과 2000년의 학동기와 2003년 학동전기 소아에서의 아토피피부염의 역학적 변화에 관한 전국적인 연구", Allergy Asthma & Respiratory Diseases, 13(4), pp.227~237 (2003), 대한 소아알레르기 호흡기학회
  2. Shultz, L.F., "Epidemiology of atopic dermatitis", Immunol Allergy Clin North AM, 22, pp.1~24 (2002)
  3. 김수찬, "피부외용제에 의한 부작용 사례 연구", 대한피부과학회지, 41(9), pp.1129~1135 (2003), 대한피부과학회
  4. Sameer Kumar, "Exploratory analysis of global cosmetic industry: major players, technology and market trends", Technovation, 25(11), pp.1263~1230 (2005)
  5. Kuo-Hsien Wang, "Cosmetic applications of selected traditional Chinese herbal medicines", Journal of Ethnopharmacology, 106(3), pp.353~310 (2006)
  6. 신동철, "한약재복합 추출물의 인간피부섬유아세포 HS68에 대한 항노화 효과", 대한본초학회지, 29(2), pp.39~45 (2014), 대한본초학회
  7. 윤대철, "아토피 피부염 환자에서 黃連解毒湯이 함유된 한방화장품에 대한 임상 연구", 동의생리병리학회지, 22(6), pp.1611~1620 (2008), 한의병리학회
  8. J. J. Cho, "Isolation and characterization of elastse inhibitor from Areca catechu", J. Soc. Cosmet. Sci. Korea, 35, pp.163~ (2000)
  9. "한방화장품은 2012년 시행된 한방화장품 표시, 광고 가이드라인 의 기준에 적합한 화장품을 말함", ~
  10. 신민교, "원색임상본초학", pp.308~309 (1986), 남산당
  11. 이상인, "본초학", pp.178~ (1992), 영림사
  12. Shang X, "The genus Scutellaria an ethnopharmacological and phytochemical review", J Ethnopharmacol, 128, pp.279~313 (2010)
  13. Kim EH, "Anti-inflammatory effects of Scutellaria baicalensis extract via suppression of immune modulators and MAP kinase signaling molecules", J Ethnopharmacol, 126, pp.320~331 (2009)
  14. Hui KM, "Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi", Biochem Pharmacol, 64, pp.1415~1424 (2002)
  15. 홍성진, "α-MSH 유도성 멜라닌 합성에 있어서 황금 추출물의 역할과 작용기전 연구", 한방안이비인후피부과학회지, 22(2), pp.104~117 (2009), 대한한방안이비인후피부과학회
  16. Kimura Y, "Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice", Eur J Pharmacol, 661, pp.124~132 (2011)
  17. 임현, "Inhibition of Chronic Skin Inflammation by Topical Anti-inflammatory Flavonoid Preparation, Ato Formula？", Archives of Pharmacal Research, 29(6), pp.31~31 (2006), 대한약학회
  18. 정영수, "황금 (Scutellariae Radix) 에탄올 추출물의 Hyaluronic Acid 합성 효과에 대한 연구", 대한미용학회지, 11(4), pp.309~313 (2015), 대한미용학회
  19. T. Nakajima, "Inhibitory effect of baicalein, a flavonoid in Scutellaria root, on eotaxin production by human dermal fibroblasts", Planta Med, 67, pp.132~ (2001)
  20. K. Sekiya, "Okuda, Selective inhibition of platelet lipoxygenase by baicalein", Biochem, Biophys, Res, Commun, 105, pp.1090~ (1982)
  21. 윤미영, "황금가수분해물의 아토피 피부염 예방효과", 한국미용학회지, 18(5), pp.1104~1111 (2012), 한국미용학회
  22. 전국 한의과대학 본초학교실, "본초학", pp.180~181 (2001), 영림사
  23. YJ Kim, "Antioxidant Activity of Water-Extract from Coptis chinensis Franch", Korean journal of life science, 10(3), pp.241~246 (2000)
  24. J. L. Smilanick, , Phytopathology, 76, pp.805~808 (1986)
  25. 김기배, "黃連과 구성 생화합물의 약리작용에 대한 고찰", 대한한의학회지, 33(3), pp.160~183 (2012), 대한한의학회
  26. 이인수, "黃連解毒湯의 사람비점막 섬유아세포 IL-8 분비에 대한 효과", 대한안이비인후피부과학회지, 16(3), pp.68~81 (2003)
  27. 허준, "동의보감", pp.1654~ (2003), 여강출판사
  28. 이재근, "黃連이 구강암 세포에서의 세포자멸사에 미치는 영향", 한방안이비인후피부과학회지, 22(2), pp.50~59 (2009), 대한한방안이비인후피부과학회
  29. 원승환, "手部의 표재성 2度 火傷의 鍼治療 1례에 관한 臨床的 考察", Journal of Acupuncture Research, 22(1), pp.13~18 (2005), 대한침구의학회
  30. DI Kim, "The Inhibitory Effects of Schizandrae Fructus and Coptidis Rhizoma on the IL-6, IL-16, GM-CSF MRNA level of BEAS-2B Human Epithelial Cells", 경희의학, 17(2), pp.199~213 (2001)
  31. 박용기, "黃連의 주성분인 Berberine의 뇌신경소교세포로부터 LPS에 의해 유도되는 염증매개물질 생성억제효과", 대한본초학회지, 22(4), pp.117~125 (2007), 대한본초학회
  32. Jong-Cheng Mou, "Effects of Coptidis Rhizoma Herbal Acupuncture Extract on the Acute Gastric Mucosal Lesion Progression Induced by Compound 48", 80 in Rats, 2013, pp.28(1), 1~7[DOI]
  33. 서형식, "황련의 증량에 따른 전탕액이 Pseudomonas aeruginosa에 미치는 항균효과에 대한 실험적 연구", Journal of Pharmacopuncture, 10(1), pp.17~21 (2007), 대한약침학회
  34. Higaki S, "The correlation of kampo formulations and their ingredients on anti-bacterial activities against propionibacterium acnes", J Dermatol, 22, pp.4~9 (1995)
  35. 유진곤, "口瘡의 外用藥으로 多用되는 黃柏, 靑黛, 白礬 및 五倍子의 抗炎作用에 관한 硏究", 한방안이비인후피부과학회지, 18(1), pp.183~198 (2005), 대한한방안이비인후피부과학회
  36. 박영범, "결명자 추출물의 아질산염 소거인자 특성", KOREAN J. FOOD. SCI TECHNOL, 27(1), pp.124~ (1995)
  37. 江蘇新醫學院, "中藥大辭典", pp.1439~1441 (1978), 上海科學技術出版社
  38. 載新民, "中國藥材學(下)", pp.1058~1059 (1981), 業書局
  39. 동양의학대사전편찬위원회, "동양의학대사전(六卷)", pp.576~578 (1999), 경희대학교
  40. Ki H.J, "Bilgialefects of Houtuyniacordata Thunbextactonmurne and human mmune systm", MS, pp.2000
  41. 황인승, "마우스 대식세포를 이용한 어성초(魚腥草) 물추출물의 항염효능연구", 대한본초학회지, 29(4), pp.83~89 (2014), 대한본초학회
  42. 최옥병, "어성초 추출물의 혈관 평활근 세포 이주 및 증식 억제 활성에 관한 연구", 생약학회지, 42(2), pp.182~186 (2011), 한국생약학회
  43. 김정현, "어성초(魚腥草)의 면역활성에 미치는 영향", 대한한방부인과학회지, 25(2), pp.12~22 (2012), 대한한방부인과학회
  44. 이희조, "魚腥草가 비만세포 매개 염증반응에 미치는 영향", 한방안이비인후피부과학회지, 22(2), pp.60~73 (2009), 대한한방안이비인후피부과학회
  45. Lee TB, "Illustrated Flora of Korea", pp.252~251 (1979), Hyangmoonsa
  46. Lee JH, "The inhibitory Effects of the methanol extract of Houttuynia cordata THUNB, against cadmium induced cytotoxicity (V)", Kor J Pharmacogn, 32, pp.61~66 (2001)
  47. 이광소, "어성초와 복분자의 항알레르기 기전", 박사, 의학, pp.2003

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