마삭줄로부터 멜라닌 생성 저해 활성 성분 규명
Characterization of the Components Inhibiting Melanin Synthesis from Trachelospermum asiaticum (Siebold & Zucc.) Nakai.
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초록
The extracts of Trachelospermum asiaticum were examined for the inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells, to evaluate as a functional ingredient for cosmetics. Similar to the effect of arbutin at 50 μg/mL (38%), 70% ethanol extracts, chloroform and ethyl acetate layers showed 34%, 52% and 45% of inhibition at 100 μg/mL. Investigation of constituents from the ethanol extracts of T. asiaticum led to the identification of six compounds; arctigenin (1), matairesinol (2), arctiin(3), luteolin 7-O-glucoside (4), quercitrin (5), luteolin 4'-O-glucoside (6). The compound (5) was isolated from T. asiaticum for the first time, and more interestingly, compounds 1∼3 showed 58%, 84% and 14% inhibitory effect of melanin synthesis. Based on these resutls, we can propose T. asiaticum is a natural cosmeceutical ingredient with skin brightening effect.
Abstract
The extracts of Trachelospermum asiaticum were examined for the inhibitory effect on the melanin synthesis in B16/F10 mouse melanoma cells, to evaluate as a functional ingredient for cosmetics. Similar to the effect of arbutin at 50 μg/mL (38%), 70% ethanol extracts, chloroform and ethyl acetate layers showed 34%, 52% and 45% of inhibition at 100 μg/mL. Investigation of constituents from the ethanol extracts of T. asiaticum led to the identification of six compounds; arctigenin (1), matairesinol (2), arctiin(3), luteolin 7-O-glucoside (4), quercitrin (5), luteolin 4'-O-glucoside (6). The compound (5) was isolated from T. asiaticum for the first time, and more interestingly, compounds 1∼3 showed 58%, 84% and 14% inhibitory effect of melanin synthesis. Based on these resutls, we can propose T. asiaticum is a natural cosmeceutical ingredient with skin brightening effect.
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