삽관성 육아종과 접촉성 육아종에 대한 치료 결과 분석
Treatment Results of Vocal Process Granuloma: Intubation Versus Contact Granuloma
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Objectives Vocal process granulomas (VPGs) are benign lesions of the larynx, typically contact granulomas (CG) and intubation granulomas (IG). The two diseases are known to have different clinical manifestations despite having the same pathological features. The purpose of this study was to analyze the treatment results for CG and IG and to obtain clinical information.Materials and Method We retrospectively reviewed the medical records of patients diagnosed with VPG between January 2015 and December 2018. The patient’s age, sex, medical history, lesion size, lesion type, reflux finding score, response to treatment, duration of treatment, and follow-up period were compared.Results In total, 32 patients were included in the study, of which 18 were CG and 14 were IG. In the CG group, males were dominant (n=15, 83.3%), whereas in the IG group, females were dominant (n=11, 78.6%) (p=0.0009). The response to medical treatment using proton pump inhibitor and steroid inhaler was better in the IG group (11/14, 78.6%) than in the CG group (7/18, 38.9%) (p=0.036). Of the 14 patients who did not respond to medical treatment, 5 received botulium toxin injections, and all 5 had complete remission. The duration of medical treatment was significantly longer in the IG group (p=0.0029).Conclusion IG was more common in female, and CG was more dominant in male. IG had better response to medical treatment using proton pump inhibitor and steroid inhaler than CG.
Abstract
Background and Objectives Vocal process granulomas (VPGs) are benign lesions of the larynx, typically contact granulomas (CG) and intubation granulomas (IG). The two diseases are known to have different clinical manifestations despite having the same pathological features. The purpose of this study was to analyze the treatment results for CG and IG and to obtain clinical information.Materials and Method We retrospectively reviewed the medical records of patients diagnosed with VPG between January 2015 and December 2018. The patient’s age, sex, medical history, lesion size, lesion type, reflux finding score, response to treatment, duration of treatment, and follow-up period were compared.Results In total, 32 patients were included in the study, of which 18 were CG and 14 were IG. In the CG group, males were dominant (n=15, 83.3%), whereas in the IG group, females were dominant (n=11, 78.6%) (p=0.0009). The response to medical treatment using proton pump inhibitor and steroid inhaler was better in the IG group (11/14, 78.6%) than in the CG group (7/18, 38.9%) (p=0.036). Of the 14 patients who did not respond to medical treatment, 5 received botulium toxin injections, and all 5 had complete remission. The duration of medical treatment was significantly longer in the IG group (p=0.0029).Conclusion IG was more common in female, and CG was more dominant in male. IG had better response to medical treatment using proton pump inhibitor and steroid inhaler than CG.
참고문헌 (19)
- Hong-Gang D, "Surgery and proton pump inhibitors for treatment of vocal process granulomas", Eur Arch Otorhinolaryngol, 270(11), pp.2921~2926 (2013)
- Wang CT, "Intralesional steroid injection : An alternative treatment option for vocal process granuloma in ten patients", Clin Otolaryngol, 38(1), pp.77~81 (2013)
- Karkos PD, "Vocal process granulomas : A systematic review of treatment", Ann Otol Rhinol Laryngol, 213(5), pp.314~320 (2014)
- Ylitalo R, "Extraesophageal reflux in patients with contact granuloma : A prospective controlled study", Ann Otol Rhinol Laryngol, 111(5 Pt 1), pp.441~446 (2002)
- Leonard R, "Effects of voice therapy on vocal process granuloma : A phonoscopic approach", Am J Otolaryngol, 26(2), pp.101~107 (2005)
- Martins RH, "Laryngeal and voice disorders in patients with gastroesophageal symptoms. Correlation with pH-monitoring", Acta Cir Bras, 27(11), pp.821~828 (2012)
- Hillel AT, "Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas : A series of 67 granulomas", Ann Otol Rhinol Laryngol, 119(5), pp.325~330 (2010)
- Rimoli CF, "Treatment of post-intubation laryngeal granulomas : Systematic review and proportional meta-analysis", Braz J Otorhinolaryngol, 84(6), pp.781~789 (2018)
- Lee SW, "Comparison of treatment modalities for contact granuloma : A nationwide multicenter study", Laryngoscope, 124(5), pp.1187~1191 (2014)
- McFerran DJ, "Vocal process granulomata", J Laryngol Otol, 108(3), pp.216~220 (1994)
- Lee DH, "Surgical treatment outcomes of vocal process granuloma after endotracheal intubation", J Craniofac Surg, 29(4), pp.e387~e389 (2018)
- Havas TE, "A management strategy for vocal process granulomas", Laryngoscope, 109(2 Pt 1), pp.301~306 (1999)
- Wani MK, "Laryngeal contact granuloma", Laryngoscope, 109(10), pp.1589~1593 (1999)
- Roh HJ, "Topical inhalant steroid(budesonide, Pulmicort nasal)therapy in intubation granuloma", J Laryngol Otol, 113(5), pp.427~432 (1999)
- Wang CP, "Vocal process granuloma-A result of long-term observation in 53 patients", Oral Oncol, 45(9), pp.821~825 (2009)
- Nasri S, "Treatment of vocal fold granuloma using botulinum toxin type A", Laryngoscope, 105(6), pp.585~588 (1995)
- Damrose EJ, "Botulinum toxin as adjunctive therapy in refractory laryngeal granuloma", J Laryngol Otol, 122(8), pp.824~828 (2008)
- Yılmaz T, "Botulinum toxin A for treatment of contact granuloma", J Voice, 30(6), pp.741~743 (2016)
- Yilmaz T, "Recurrent contact granuloma : Experience with excision and botulinum toxin injection", JAMA Otolaryngol Head Neck Surg, 139(6), pp.579~583 (2013)