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Exploring the contextual factors of episodic memory: dissociating distinct social, behavioral, and intentional episodic encoding from spatio-temporal contexts based on medial temporal lobe-cortical networks

이승구|한상훈|유수민|박종현|나윤진
한국인지과학회 (The Korean Society for Cognitive Science)|2022.06|인지과학 (Korean Journal of Cognitive Science)|제33권 제2호|pp. 109-133|DOI 10.19066/cogsci.2022.33.2.002

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키워드

해마Hippocampus출처기억Contextual MemoryHigh-resolution fMRIFunctional Connectivity Pattern Analysis고해상도 fMRI기능적 연결성 패턴 분석
주제분류인지과학

초록

Episodic memory consists of a core event and the associated contexts. Although the role of the hippocampus and its neighboring regions in contextual representations during encoding has become increasingly evident, it remains unclear how these regions handle various context-specific information other than spatio-temporal contexts. Using high-resolution functional MRI, we explored the patterns of the medial temporal lobe (MTL) and cortical regions’ involvement during the encoding of various types of contextual information (i.e., journalism principle 5W1H): “Who did it?,” “Why did it happen?,” “What happened?,” “When did it happen?,” “Where did it happen?,” and “How did it happen?” Participants answered six different contextual questions while looking at simple experimental events consisting of two faces with one object on the screen. The MTL was divided to sub-regions by hierarchical clustering from resting-state data. General linear model analyses revealed a stronger activation of MTL sub-regions, the prefrontal lobe (PFC), and the inferior parietal lobule (IPL) during social (Who), behavioral (How), and intentional (Why) contextual processing when compared with spatio-temporal (Where/When) contextual processing. To further investigate the functional networks involved in contextual encoding dissociation, a multivariate pattern analysis was conducted with features selected as the task-based connectivity links between the hippocampal subfields and PFC/IPL. Each social, behavioral, and intentional contextual processing was individually and successfully classified from spatio-temporal contextual processing, respectively. Thus, specific contexts in episodic memory, namely social, behavior, and intention, involve distinct functional connectivity patterns that are distinct from those for spatio-temporal contextual memory.

Abstract

Episodic memory consists of a core event and the associated contexts. Although the role of the hippocampus and its neighboring regions in contextual representations during encoding has become increasingly evident, it remains unclear how these regions handle various context-specific information other than spatio-temporal contexts. Using high-resolution functional MRI, we explored the patterns of the medial temporal lobe (MTL) and cortical regions’ involvement during the encoding of various types of contextual information (i.e., journalism principle 5W1H): “Who did it?,” “Why did it happen?,” “What happened?,” “When did it happen?,” “Where did it happen?,” and “How did it happen?” Participants answered six different contextual questions while looking at simple experimental events consisting of two faces with one object on the screen. The MTL was divided to sub-regions by hierarchical clustering from resting-state data. General linear model analyses revealed a stronger activation of MTL sub-regions, the prefrontal lobe (PFC), and the inferior parietal lobule (IPL) during social (Who), behavioral (How), and intentional (Why) contextual processing when compared with spatio-temporal (Where/When) contextual processing. To further investigate the functional networks involved in contextual encoding dissociation, a multivariate pattern analysis was conducted with features selected as the task-based connectivity links between the hippocampal subfields and PFC/IPL. Each social, behavioral, and intentional contextual processing was individually and successfully classified from spatio-temporal contextual processing, respectively. Thus, specific contexts in episodic memory, namely social, behavior, and intention, involve distinct functional connectivity patterns that are distinct from those for spatio-temporal contextual memory.

참고문헌 (49)

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