본문 바로가기
KERD
논문KCI 등재

한약을 이용한 아토피 임상연구의 경향에 관한 연구

Overview for Pattern and Results of Herbal Medicine-derived Atopic Dermatitis Clinical Researches

김윤희
대한한방소아과학회 (The Association of Pediatrics of Korean Medicine)|2012.05|대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)|제26권 제2호|pp. 53-61|DOI http://dx.doi.org/

1

조회

0

다운로드

8

인용

0

참고문헌

키워드

Herbal medicineClinical trialRCT
주제분류한의학

초록

Objective: 국제학술지에 발표된 아토피피부염에 관한 임상연구의 동향을 살펴봄으로써 향후 아토피 치료법의 개발이나 과학적 임상연구의 수행에서 하나의 기초자료로 삼고자 함. Methods: Pubmed, EBSCO, Medline 데이터베이스를 이용하여 2011년 12월까지의 논문을 대상으로 검색. tilte 및 abstract를 대상으로 ‘atopic dermatitis’(or ’atopic eczema’) AND ’clinical trial’(or ’clinical study‘ or ’Randomized controlled trial’) AND ’herbal medicine’(or ’herb’ or ’herbal’ or ’chinese herb’)의 term을 이용하여 검색함. Results: 임상연구 논문 24편을 분석해본 결과 한약 또는 단미제를 사용한 임상증례 관찰연구는 1997년 이후 14편이 발표되었으며, RCT에 관련한 임상연구는 1992년도 이후 10편의 논문이 보고됨. RCT형태의 임상시험 연구에서는 외용제가 4건 단미제 1건, 복합처방 5건으로 나타났다. 복합처방을 연구대상으로 선택한 경우에 있어서는 모두 유의한 효과를 보였으며 외용제의 경우 4건 중 1건에서만 유의한 결과를 얻음. Conclusion: 현재까지의 아토피피부염 임상연구 경향을 관찰함으로써 향후 과학적 연구를 수행하는 방법론이나 설계에 있어 하나의 기초자료가 될 수 있을 것으로 사료됨.

Abstract

Objectives To make comprehensive feature of clinical trials using herbal medicine and their results by today, then help a strategy for herbal medication–derived clinical studies in the future. Methods Through medical website (Pubmed․EBSCO․Medline), foreign clinical literatures about atopic dermatitis and herbal medicine were searched. And domestic clinical literatures about atopic dermatitis using internet website (OASIS) and hand-searching. Analysis was performed according to distribution mainly by subject, study design,number by year and its efficacy. Results and Conclusions Seventy-nine (Domestic literatures: Fifty, Foreign literatures: Twenty-nine) literatures were selected according to inclusion criteria of clinical study. 80% of domestic clinical literatures were observational studies, 50% of foreign were intervention. There were six adverse effect case studies, two follow-ups, one case report, four translational and four uncontrolled clinical trials in foreign literatures. And nineteen case reports, eighteen case series, two follow-up and five uncontrolled clinical studies in domestic. Six RCTs have established by four external herb therapy and two decoctions in Korea, showed positive effects. Three out of four external applications RCTs, four out of seven decoctions showed positive results in foreign studies. This study revealed the current status of atopic dermatitis clinical research using herbal drugs. To put clinical trials to use of herbal medicine in the treatment atopic dermatitis, scientific and objective-based studies should be needed.

참고문헌 (44)

  1. Peroni DG, "Prevalence and Risk Factors for Atopic Dermatitis in Preschool Children", Br J Dermatol, 158, pp.539~543 (2008)
  2. Stensen L, "Change in Prevalence of Atopic Dermatitis between 1986 and 2001 among Children", Allergy Asthma Proc, 29, pp.392~396 (2008)
  3. Williams HC, "Epidemiology of Atopic Dermatitis", Clin Exp Dermatol, 25, pp.522~529 (2000)
  4. Fennessy M, "The Epidemiology and Experience of Atopic Eczema during Childhood: a Discussion Paper on the Implications of Current Knowledge for Health Care, Public Health Policy and Research", J Epidemiol Community Health, 54, pp.581~589 (2000)
  5. 지혜미, "2006년 초등학생의 알레르기 질환 유병률의 전국적 역학조사", Allergy Asthma & Respiratory Diseases, 19(2), pp.165~172 (2009), 대한 소아알레르기 호흡기학회
  6. Katayama I, "Japanese Society of Allergology", Japanese Guideline for Atopic Dermatitis. Allergol Int, 60, pp.205~220 (2011)
  7. Schmitt J, "Systemic Treatment of Severe Atopic Eczema: a Systematic Review", Acta Derm Venereol, 87, pp.100~111 (2007)
  8. Hon KL, "A Survey of Traditional Chinese Medicine Use in Children with Atopic Dermatitis Attending a Paediatric Dermatology Clinic", J Dermatolog Treat, 16, pp.154~157 (2005)
  9. Boneberger S, "Complementary Therapy for Atopic Dermatitis and Other Allergic Skin Disease: Facts and Controversies", Clin Dermatol, 28, pp.57~61 (2010)
  10. 최인화, "A Clinical Study of Shi Ho Cheong Gan-San on Blood Heat Pattern Atopic Dermatitis: a randomized, double-blind clinical trial", 한방안이비인후피부과학회지, 24(1), pp.96~110 (2011), 대한한방안이비인후피부과학회
  11. 오민지, "달팽이 점액이 아토피 피부염 환자의 피부장벽 회복에 미치는 영향", 한방안이비인후피부과학회지, 23(3), pp.138~153 (2010), 대한한방안이비인후피부과학회
  12. 황선복, "A Double-blind, Randomized, Placebo-controlled Intervention Study of the Efficacy and Safety of ‘Atomento solution &cream’ in patients with Atopic Dermatitis", 한방안이비인후피부과학회지, 22(2), pp.223~237 (2009), 대한한방안이비인후피부과학회
  13. 윤대철, "아토피 피부염 환자에서 黃連解毒湯이 함유된 한방화장품에 대한 임상 연구", 동의생리병리학회지, 22(6), pp.1611~1620 (2008), 대한동의병리학회
  14. 김성호, "連翹升麻湯이 함유된 한방화장품이 아토피 피부염에 미치는 임상 연구", 한방안이비인후피부과학회지, 21(2), pp.126~141 (2008), 대한한방안이비인후피부과학회
  15. 신상호, "升葛湯을 사용한 아토피 피부염 환자에 대한 임상시험", 한방안이비인후피부과학회지, 20(2), pp.199~212 (2007), 대한한방안이비인후피부과학회
  16. Cheng HM, "The Efficacy and Safety of a Chinese Herbal Product (Xiao-Feng-San) for the Treatment of Refractory Atopic Dermatitis: a Randomized, Double-blind, Placebo-controlled Trial", Int Arch Allergy Immunol, 155(2), pp.141~148 (2011)
  17. Kobayashi H, "Efficacy and Safety of a Traditional Herbal Medicine, Hochu-ekki-to in the Long-term Management of Kikyo (Delicate Constitution) Patients with Atopic Dermatitis: A 6-month, Multicenter, Double-blind, Randomized, Placebo-controlled Study", Evid Based Complement Alternat Med, 7(3), pp.367~373 (2010)
  18. Abramovits W, "Patient-reported Outcomes from a Multicenter, Randomized, Vehicle-controlled Clinical Study of MAS063DP (Atopiclair) in the Management of Mild-to-moderate Atopic Dermatitis in Adults", J Dermatolog Treat, 19(6), pp.327~332 (2008)
  19. Klövekorn W, "A Randomized, Double-blind, Vehicle-controlled, Half-side Comparison with a Herbal Ointment Containing Mahonia Aquifolium, Viola Tricolor and Centella Asiatica for the Treatment of Mild-to-moderate Atopic Dermatitis", Int J Clin Pharmacol Ther, 45(11), pp.583~591 (2007)
  20. Hon KL, "Efficacy and Tolerability of a Chinese Herbal Medicine Concoction for Treatment of Atopic Dermatitis: a Randomized, Double-blind, Placebo-controlled Study", Br J Dermatol, 157(2), pp.357~363 (2007)
  21. Shapira MY, "Treatment of Atopic Dermatitis with Herbal Combination of Eleutherococcus, Achillea Millefolium, and Lamium Album Has No Advantage over Placebo: a Double blind, Placebo-controlled, Randomized Trial", J Am Acad Dermatol, 52(4), pp.691~693 (2005)
  22. Belloni G, "A Randomised, Double-blind, Vehicle-controlled Study to Evaluate the Efficacy and Safety of MAS063D (Atopiclair) in the Treatment of Mild to Moderate Atopic Dermatitis", Eur J Dermatol, 15(1), pp.31~36 (2005)
  23. Jackson CM, "The Effects of Butterbur on the Histamine and Allergen Cutaneous Response", Ann Allergy Asthma Immunol, 92(2), pp.250~254 (2004)
  24. Saeedi M, "he Treatment of Atopic Dermatitis with Licorice Gel", J Dermatolog Treat, 14(3), pp.153~157 (2003)
  25. Fung AY, "A Controlled Trial of Traditional Chinese Herbal Medicine in Chinese Patients with Recalcitrant Atopic Dermatitis", Int J Dermatol, 38(5), pp.387~392 (1999)
  26. Sheehan MP, "Efficacy of Traditional Chinese Herbal Therapy in Adult Atopic Dermatitis", Lancet, 340, pp.13~17 (1992)
  27. Sheehan MP, "A Controlled Trial of Traditional Chinese Medicinal Plants in Widespread Non-exudative Atopic Eczema", Br J Dermatol, 126(2), pp.179~184 (1992)
  28. Kui Dong Kang, "Herbal Medication Aggravates Cataract Formation: A Case Report", Journal of Korean Medical Science, 23(3), pp.537~539 (2008), 대한의학회
  29. Chang YP, "Licorice-induced Hypokalemic Paralysis in a Patient with Chronic Atopic Dermatitis", J Med Sci, 26(4), pp.129~132 (2006)
  30. Motoyama O, "A Boy with Recurrent Hemorrhagic Cystitis during Treatment with Chinese Herbal Medicine", Clin Exp Nephrol, 6(2), pp.121~124 (2002)
  31. Wong HC, "Acute Urticaria Associated with Chinese Herbal Medicine Used for Atopic Dermatitis", Canadian J Allergy Clin Immunol, 6(2), pp.77~79 (2001)
  32. Uejima E, "The Risks of Using Personally Imported Traditional Chinese Drugs (Decoction)", Japanese J Clin Pharmacol Ther, 31(6), pp.693~699 (2000)
  33. Ferguson JE, "Reversible Dilated Cardiomyopathy Following Treatment of Atopic Eczema with Chinese Herbal Medicine Ferguson", Br J Dermatol, 136(4), pp.592~593 (1997)
  34. Van Bever HP, "Features of Childhood Atopic Dermatitis", Asian Pac J Allergy Immunol, 29, pp.15~24 (2011)
  35. Tinsley JA, "The Hazards of Psychotropic Herbs", Minn Med, 82(5), pp.29~31 (1999)
  36. Siow YL, "Emerging Issues in Traditional Chinese Medicine", Can J Physiol Pharmacol, 83(4), pp.321~334 (2005)
  37. Son C, "Overview for Pattern and Results of Moxibustion-derived Clinical Trials", J Meridian Acupoint, 26, pp.41~49 (2009)
  38. Hon KL, "Chinese Herbal Medicine Research in Eczema Treatment", Chinese Med, 6, pp.17~ (2011)
  39. Coulter ID, "Evidence Based Complementary Medicine: Promise and Problems", Forsch komplenentmed, 14(2), pp.102~108 (2007)
  40. Kim NK, "Hwangryunhaedoktang in Adult Patients with Atopic Dermatitis: a Randomised, Double-blind, Placebo-controlled, Two-centre trial - Study Protocol", BMC Complement Alternat Med, 11, pp.68~ (2011)
  41. Lee J, "Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation", JOURNAL OF ETHNOPHARMACOLOGY, 96(96), pp.211~219 (2005), ELSEVIER IRELAND LTD
  42. Xu XJ, "Modulation by Chinese Herbal Therapy of Immune Mechanisms in the Skin of Patients with Atopic Eczema", Br J Dermatol, 36(1), pp.54~59 (1997)
  43. Latchman Y, "Association of Immunological Changes with Clinical Efficacy in Atopic Eczema Patients Treated with Traditional Chinese Herbal Therapy (Zemaphyte)", Int Arch Allergy Immunol, 109(3), pp.243~249 (1996)
  44. Henderson CA, "An Open Study Comparing the Efficacy of Two Different Chinese Herbal Therapy Formulations in Atopic Eczema and Their Effects on Circulating Activated T-lymphocytes", J Dermatolog Treat, 11(2), pp.91~96 (2000)

관련 논문AI추천

아토피 피부염의 한약 치료에 대한 무작위대조군연구 중심의 연구 동향 - CNKI를 중심으로강수진, 박민철, 심유화, 양금진, 이주현, 조은희, 홍지은한의병리학회 · 동의생리병리학회지2020 · 제34권 제2호아토피 피부염의 외치법에 대한 고찰 - 국내 논문을 중심으로고우신, 김미보, 박선규, 변석미, 신상호, 윤화정, 이호섭대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2008 · 제21권 제2호한약의 아토피 피부염 치료에 대한 예비 임상 연구이훈, 김영란, 김호철, 윤철상, 임영권, 정지아, 조윤희, 허광욱대한한방소아과학회 · 대한한방소아과학회지2006 · 제20권 제3호아토피 피부염 증례 연구 분석 -한약 처방을 중심으로-강동원, 김규석, 김봉현, 김윤범, 박소영, 박중군, 한창이대한한방안이비인후피부과학회 · 한방안이비인후피부과학회지2019 · 제32권 제3호일본의 아토피피부염 치료에 대한 최신연구 동향 -식품, 화한의학(和漢醫學) 중심으로-김기봉, 이장천, 하나리대한한방소아과학회 · 대한한방소아과학회지2012 · 제26권 제1호아토피피부염의 보완의학염혜영, 이수형대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2008 · 제18권 제4호

이 간행물의 다른 논문 (7건)

三伏貼의 호흡기 질환에 대한 영향김초영, 장규태, 이선행pp. 1-12甘松香 (감송향)이 아토피樣 (양) 피부염에 미치는 영향민들레, 박은정pp. 13-24발달장애 아동의 허약 증상에 관한 연구정선경, 이승연, 유선애pp. 25-34교통사고 소아환자 121례를 통한 임상적 고찰김윤희, 조민서, 한재경pp. 35-46소아 원형탈모증 치험 1례정민정, 서형식, 황보민pp. 47-52
원문 보기