소아 야뇨의 한약치료에 대한 임상연구 동향-중의학 논문을 중심으로-
Review of Clinical Researches for Herbal Medicine Treatment on Nocturnal Enuresis in Children
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Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of nocturnal enuresis in children by analyzing randomized controlled trials conducted in China. Methods We searched literatures from China National Knowledge Infrastructure published up to 19 January, 2018. Selected literatures were collected and analyzed in order of publication year, and then demographic information, treatment method, duration of illness, duration of treatment, follow-up period, outcome measurement and adverse events. Results A total of 34 studies were selected for the analysis. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group, and the recurrence rate and complete cure rate were also found to be more effective in the herbal medicine treatment group. The most frequently used medical herb was Alpiniae Fructus (益智仁), and the use of medical herbs belong to tonifying yang (補陽藥), tonifying qi (補氣藥), and astringing essence strengthening collapse medicine (澁精縮尿止帶藥) were relatively high. The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that a herbal medicine treatment can be effective and safe option for treating pediatric nocturnal enuresis. However, additional well-designed clinical studies need to be performed to establish a basis.
Abstract
Objectives The purpose of this study is to evaluate the efficacy and safety of herbal medication for the treatment of nocturnal enuresis in children by analyzing randomized controlled trials conducted in China. Methods We searched literatures from China National Knowledge Infrastructure published up to 19 January, 2018. Selected literatures were collected and analyzed in order of publication year, and then demographic information, treatment method, duration of illness, duration of treatment, follow-up period, outcome measurement and adverse events. Results A total of 34 studies were selected for the analysis. In most studies, the total efficacy of the treatment group was reported to be higher than that of the control group, and the recurrence rate and complete cure rate were also found to be more effective in the herbal medicine treatment group. The most frequently used medical herb was Alpiniae Fructus (益智仁), and the use of medical herbs belong to tonifying yang (補陽藥), tonifying qi (補氣藥), and astringing essence strengthening collapse medicine (澁精縮尿止帶藥) were relatively high. The adverse events rate for the herbal medicine treatment group were significantly lower than those in the Western medicine treatment group. Conclusions This study showed that a herbal medicine treatment can be effective and safe option for treating pediatric nocturnal enuresis. However, additional well-designed clinical studies need to be performed to establish a basis.
참고문헌 (72)
- Neveus T, "The standardization of terminology of lower urinary tract function in children and adolescents: report from the standardization commit- tee of the International Children's Continence Society", J Urol, 176(1), pp.316~324 (2006)
- von Gontard A, "Clinical behavioral problems in day- and night-wetting children", Pediatr Nephrol, 13(8), pp.662~667 (1999)[DOI]
- Wan J, "Enuresis and common voiding abnormalities", Pediatr Clin North Am, 44(5), pp.1117~1131 (1997)[DOI]
- Forsythe WI, "Enuresis and spontaneous cure rate: study of 1129 enuretics", Arch Dis Child, 49(4), pp.259~263 (1974)[DOI]
- Wille S, "Comparison of desmopressin and enuresis alarm for nocturnal enuresis", Arch Dis Child, 61(1), pp.30~33 (1986)[DOI]
- Glazener CM, "Alarm interventions for nocturnal enuresis in children", Cochrane Database Syst Rev, 18(2) (2005)
- Heo J, "Donguibogam", pp.173~174 (2014), Nam San Dang Publishing Co.
- Cho HJ, "The clinical study on the effect of radix ephedrae on the nocturnal enuresis in Korean children", J Korean Orient Pediatr, 15(1), pp.155~164 (2001)
- 오주영, "中極, 關元 穴位를 이용한 전침 치료 야뇨 환아 3례", 대한한방소아과학회지, 19(1), pp.103~115 (2005), 대한한방소아과학회
- 주봉현, "기歸補腎湯 투여가 야뇨증 환아에 미치는 영향에 관한 임상적 연구", 대한한방소아과학회지, 20(2), pp.139~146 (2006), 대한한방소아과학회
- 김지영, "關元(CV4)에 溫筒灸를 시술한 夜尿 患兒 5례 보고", 대한한방소아과학회지, 24(2), pp.159~168 (2010), 대한한방소아과학회
- 전보람, "수면-각성이행에 초점을 둔 소아 야뇨증 치험 2례", 대한한방소아과학회지, 30(1), pp.1~8 (2016), 대한한방소아과학회
- Oh JY, "A follow-up study of enuretic children", J Korean Orient Pediatr, 18(1), pp.179~191 (2004)
- Chang GT, "Acupuncture clinical trial study for treatment of nocturnal enuresis", J Korean Orient Pediatr, 17(2), pp.213~224 (2003)
- 오주영, "夜尿의 鍼灸 治療 硏究 -최근 중의 잡지를 중심으로-", 대한한방소아과학회지, 19(1), pp.83~102 (2005), 대한한방소아과학회
- 노영희, "소아 夜尿 치료에 대한 최신연구 동향 - 침구치료, 정신요법, 카이로프락틱 중심으로 -", 대한한방소아과학회지, 25(3), pp.1~11 (2011), 대한한방소아과학회
- Sun XJ, "Systematic evaluation of the treatment for enuresis in children with the kidney-nourishing herbs for internal use", Chin Pediatr Integr Tradit West Med, 3(6), pp.481~487 (2011)
- Yu P, "Systematic evaluation of literatures of TCM on nocturnal enuresis in children", Chin J Tradit Chin Med, 27(7), pp.1818~1822 (2012)
- Wang ZY, "Guideline for TCM pediatrics clinical diagnosis and treatment.infantile enuresis (amendment)", J Pediatr Tradit Chin Med, 14(1), pp.4~8 (2018)
- Jin HR, "Clinical observation on infantile enuresis treated by Seunggichukcheontang", Zhejiang J Integr Tradit Chin West Med, 10(2), pp.110~111 (2000)
- Lin XQ, "Mahuang decoction for treating 56 cases of pediatric enuresis", J Pract Tradit Chin Med, 16(1), pp.24~25 (2000)
- Teng YL, "Clinical observation on 50 cases of enuresis in children treated by Yunyoryeongbang", J New Chin Med, 34(12), pp.27~28 (2002)
- Zhang ZJ, "Treating 82 cases of enuresis in children with modified Ojayeonjonghwan", Chin Folk Med, 10(6), pp.52~ (2002)
- Wang FD, "Treatment of 38 cases of enuresis with Ijigyotaetang", J Pract Tradit Chin Med, 19(1), pp.18~19 (2003)
- Chen JW, "Clinical observation on 44 cases of primary enuresis treated by Yunyobang", Mod J Integrat Tradit Chin West Med, 12(4), pp.386~387 (2003)
- Wang LM, "Clinical observation on 34 children with primary enuresis treated by Gaehaphwan", Henan Tradit Chin Med, 24(10), pp.45~ (2004)
- Chen X, "Treatment of 44 cases of pediatric enuresis with TCM", J Mil Med Southwest China, 6(4), pp.37~ (2004)
- Zhu RM, "Clinical observation on children's enuresis treated by Seonpyeonsinjiyubang", Chin Hosp Pharm J, 25(4), pp.359~360 (2005)
- Xia Y, "Treatment of pediatric enuresis in 38 cases with Onhaseungjunggaesangtang", J Pract Tradit Chin Med, 21(10), pp.591~ (2005)
- Li ZZ, "Clinical observation on treatment of functional enuresis in children with self-made Yunyobang", Chin J Pract Village Doc, 13(3), pp.37~38 (2006)
- Yi JY, "Clinical observation on pediatric enuresis treated by Jichang powder", Gansu J Tradit Chin Med, 20(11), pp.38~ (2007)
- Chen YJ, "Clinical observation on 32 cases of infant enuresis treated by Gosinchuknyotang", China Chin Med Technol, 14(4), pp.286~287 (2007)
- Li XY, "Treatment of 33 cases of pediatric enuresis with modified Tosajahwan", China Pract Med, 3(3), pp.161~ (2008)
- He XT, "Clinical observation on treatment of pediatric enuresis with Onsingeonbijiyutang", J Sichuan Tradit Chin Med, 26(5), pp.84~85 (2008)
- Wang ZO, "Treatment of 40 cases of pediatric enuresis with Seoakchuknyosan", Mod Tradit Chin Med, 29(5), pp.52~53 (2009)
- Gao J, "Treatment of 30 cases of pediatric enuresis with modified Olyeongsangami", Pract Clin Med, 11(6), pp.77~78 (2010)
- Cheng YM, "Treatment of 30 cases of pediatric enuresis with herbal free granule formula", Guid J Tradit Chin Med Pharm, 16(1), pp.33~34 (2010)
- Su W, "Clinical observation on Yunyobang treating pediatric enuresis with kidney yang deficiency", Hubei J Tradit Chin Med, 32(2), pp.54~55 (2010)
- Chen XF, "Treatment of 56 cases of pediatric enuresis with combination of traditional Chinese and Western medicine", Chin J Exp Tradit Med Formul, 17(14), pp.77~78 (2011)
- Cao H, "Treatment of 30 cases of pediatric enuresis with combination of traditional Chinese and Western medicine", Chin Med Mod Dist Educ China, 10(3), pp.42~43 (2012)
- Peng YK, "Clinical observation on 32 cases of pediatric enuresis treated with Guyuan Zhigen decoction", Yunnan Chin Med J, 34(2), pp.31~ (2013)
- Luo XY, "Clinical study on the method of percolating the lung to opening the orifices for treatment of children with enuresis (lung depression and Du-vessel stagnation)", pp.2014
- Li L, "Treatment of 63 cases of pediatric enuresis with Quanquan capsules combined with bladder training", Guid China Med, 12(14), pp.282~ (2014)
- Lin LJ, "Analysis of Buzhongyiqi pills with Mahuang granules in the treat- ment of lung and spleen deficiency in children with primary nocturnal enuresis effect", Chin J Pharm Econ, (5), pp.42~43 (2014)
- Lin LJ, "Clinical observation on primary nocturnal enuresis treated by Mahuang granules com- bined with Quanquan capsules in lower belly weakness and coldness children", J New Chin Med, 46(3), pp.114~116 (2014)
- Yan PF, "Clinical observation on treatment of pediatric enuresis with Onsinyunyotang combined with desmopressin", pp.1253~1254 (2014)
- Chen ZM, "Clinical observation on treatment of 48 cases of enuresis of children with kidney yang defi- ciency assisted by Bushenzhige decoction", J New Chin Med, 46(11), pp.137~138 (2014)
- Hu P, "Clinical efficacy analysis of ephedra treating pediatric enuresis", Guid China Med, 12(12), pp.265~266 (2014)
- Liu ZH, "Clinical observation on 32 cases of primary enuresis in children treated with combination of traditional Chinese and Western medicine", J Sichuan Tradit Chin Med, 33(3), pp.117~118 (2015)
- Zhao LZ, "Observation on 50 cases of primary enuresis in children treated with combination of traditional Chinese and Western medicine", J Pract Tradit Chin Med, 31(1), pp.45~46 (2015)
- Guo X, "Clinical efficacy of Shengqizhuangyang therapy in treatment of infantile enuresis", Acta Chin Med, 31(3), pp.443~445 (2016)
- Li LB, "Clinical study on treatment of primary nocturnal enuresis in children with traditional Chinese and Western medicine", Asia Pac Tradit Med, 13(8), pp.121~122 (2017)
- Yi F, "Clinical observation on treatment of pediatric enuresis with Zhige decoction combined with dry bed training", Mod Tradit Chin Med, 37(4), pp.48~50 (2017)
- Herbalogy, "National Oriental Medicine College Collaborative Textbook Compilation Committee", 10~ (2011)
- Norgaard JP, "Diurnal antidiuretic hormone levels in enuretics", J Urol, 134(5), pp.1029~1031 (1985)[DOI]
- Weaver A, "Nocturnal enuresis in children", J Fam Health Care, 17(5), pp.159~161 (2007)
- Yeung CK, "Reduction in nocturnal functional bladder capacity is a common factor in the pathogenesis of re- fractory nocturnal enuresis", BJU Int, 90(3), pp.302~307 (2002)[DOI]
- Mueller SR, "Development of urinary control in children: some aspects of the cause and treatment of primary enuresis", J Am Med Assoc, 172, pp.1256~1261 (1960)[DOI]
- Bakwin H, "Bladder control and enuresis", pp.73~77 (1973), William Heinemann Medical Books
- Ahn HS, "Hongchangui Pediatrics", pp.997~999 (2016), Mirae N
- Kim KB, "Hanbangsoacheongsonyeonuihak (ha)", pp.167~170 (2015), Ui Sung Dang Publishing Co.
- Thiedke CC, "Nocturnal enuresis", Am Fam Physician, 67(7), pp.1499~1506 (2003)
- Kim DS, "Effects of Chukchunhwan-ex- tracts on the urine metabolism in rat", Korean J Orient Physiol Pathol, 16(2), pp.257~261 (2002)
- Yang SS, "Clinical oriental medicine II", pp.62~79 (1999), Beob In Publishing Co.
- Jang IS, "The need for clinical practice guidelines in usage of Mahuang in weight loss", J Soc Korean Med Obes Res, 7(1), pp.23~29 (2007)
- Ryu HC, "A study on proper dosage of Ma-huang", J Korean Med Assoc Clin Sanghan-Geumgwe, 5(1), pp.101~111 (2013)
- Shekelle PG, "Efficacy and safety of ephedra and Ma-huang for weight loss and athletic performance: a meta-analysis", JAMA, 289(12), pp.1537~1545 (2003)
- O'Flynn N, "Nocturnal enuresis in children and young people: NICE clinical guideline", Br J Gen Pract, 61(586), pp.360~362 (2011)[DOI]
- Deshpande AV, "Drugs for nocturnal enuresis in children (other than desmo- pressin and tricyclics)", Cochrane Database Syst Rev, 12 (2012)
- Jalkut MW, "Enuresis", Pediatr Clin North Am, 48(6), pp.1461~1488 (2001)[DOI]
- Glazener CM, "Alarm interventions for nocturnal enuresis in children", Cochrane Database Syst Rev, 18(2) (2005)
- Neveus T, "Oxybutynin, desmopressin and enuresis", J Urol, 166(6), pp.2459~2462 (2001)[DOI]
