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원형탈모증에 대한 한약의 효과: 체계적 문헌 고찰 및 메타분석

Effect of Herbal Medicine on Alopecia Areata : A Systematic Review and Meta-analysis

유선애|이동근|홍예나|손변우
대한한방소아과학회 (The Association of Pediatrics of Korean Medicine)|2024.08|대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)|제38권 제3호|pp. 29-52

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참고문헌

키워드

Systematic reviewMeta-analysisAlopecia areataHerbal medicines
주제분류한의학

초록

Objective This study aimed to evaluate the effect of herbal medicines on alopecia areata (AA). Methods We searched 10 Korean, English, Japanese, and Chinese databases for studies published until April 3, 2024. Randomized controlled trials (RCTs) assessing the effect of herbal medicines on AA were included. The Cochrane risk of bias tool was used to evaluate the quality of the studies. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), full recovery rate, and recurrence rate, using the Review Manager software. Results Seventeen RCTs were included in this study, and the TER in the treatment group was 1.48 times higher than that in the control group [Risk ratio (RR): 1.48, 95% confidence interval (CI): 1.40~1.55, I2 = 43%]. The full recovery rate was 2.25 times higher in the treatment group [RR: 2.25, 95% CI: 1.62~3.12, I2 = 53%], and the recurrence rate was 0.22 times lower, than that of the control group [RR: 0.22, 95% CI: 0.070~0.68, I2 = 0%]. Four studies reported that there were no adverse events. Four studies reported mild gastric discomfort, a mild increase in alanine aminotransferase (ALT), and constipation in the treatment group. Conclusions Our meta-analysis showed that herbal medicines are significantly effective in treating AA. However, owing to the low quality of the included studies, future clinical studies are required to determine their potential for clinical applications.

Abstract

Objective This study aimed to evaluate the effect of herbal medicines on alopecia areata (AA). Methods We searched 10 Korean, English, Japanese, and Chinese databases for studies published until April 3, 2024. Randomized controlled trials (RCTs) assessing the effect of herbal medicines on AA were included. The Cochrane risk of bias tool was used to evaluate the quality of the studies. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), full recovery rate, and recurrence rate, using the Review Manager software. Results Seventeen RCTs were included in this study, and the TER in the treatment group was 1.48 times higher than that in the control group [Risk ratio (RR): 1.48, 95% confidence interval (CI): 1.40~1.55, I2 = 43%]. The full recovery rate was 2.25 times higher in the treatment group [RR: 2.25, 95% CI: 1.62~3.12, I2 = 53%], and the recurrence rate was 0.22 times lower, than that of the control group [RR: 0.22, 95% CI: 0.070~0.68, I2 = 0%]. Four studies reported that there were no adverse events. Four studies reported mild gastric discomfort, a mild increase in alanine aminotransferase (ALT), and constipation in the treatment group. Conclusions Our meta-analysis showed that herbal medicines are significantly effective in treating AA. However, owing to the low quality of the included studies, future clinical studies are required to determine their potential for clinical applications.

참고문헌 (47)

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