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소아 식욕부진에 대한 蔘苓白朮散의 효과: 체계적 문헌고찰 및 메타분석

Effects of Samryungbaekchul-san on Childhood Anorexia: A Systematic Review and Meta-Analysis

이보람|장규태|이선행|이해솔
대한한방소아과학회 (The Association of Pediatrics of Korean Medicine)|2023.02|대한한방소아과학회지 (The Journal of Pediatrics of Korean Medicine)|제37권 제1호|pp. 1-14

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참고문헌

키워드

ChildrenSystematic reviewMeta-analysisAnorexiaSamryungbaekchul-san
주제분류한의학

초록

Objectives This study aimed to evaluate the effect of Samryungbaekchul-san on childhood anorexia. Methods We searched 11 English, Korean, Chinese, and Japanese databases for studies published up to May 30, 2022. Randomized controlled trials (RCTs) assessing the effect of Samryungbaekchul-san on childhood anorexia were included. In the meta-analysis, relative risk (RR) and 95% confidence intervals (CI) were indicated as dichotomous variables, and mean difference (MD) or standardized mean difference (SMD) and 95% CIs were indicated as continuous variables. Results We included 12 RCTs with 1345 participants. The Samryungbaekchul-san treatment group had a significantly higher total effective rate (TER) than that of the western medicine control group (RR 1.42, 95% CI 1.23–1.64, I 2 = 0%). The combined Samryungbaekchul-san and western medicine treatment group had significantly higher TER (RR 1.31, 95% CI 1.23 to 1.40, I2 = 0%) and levels of neuropeptide Y (SMD 0.93, 95% CI 0.47–1.39, I 2 = 70%) and ghrelin (SMD 1.45, 95% CI 1.14–1.76, I2 = 0%) than those of the western medicine alone group. Additionally, leptin levels were significantly lower in the combined treatment group (SMD -1.19, 95% CI -1.88 to -0.51, I2 = 86%) compared with the western medicine alone group, although statistical heterogeneity was substantial. Conclusions Samryungbaekchul-san may be effective for childhood anorexia. However, owing to limitations such as high clinical heterogeneity between the studies, unclear risks of biases, and insufficient reports of adverse events and follow-ups, well-designed RCTs with a low risk of bias are needed in the future.

Abstract

Objectives This study aimed to evaluate the effect of Samryungbaekchul-san on childhood anorexia. Methods We searched 11 English, Korean, Chinese, and Japanese databases for studies published up to May 30, 2022. Randomized controlled trials (RCTs) assessing the effect of Samryungbaekchul-san on childhood anorexia were included. In the meta-analysis, relative risk (RR) and 95% confidence intervals (CI) were indicated as dichotomous variables, and mean difference (MD) or standardized mean difference (SMD) and 95% CIs were indicated as continuous variables. Results We included 12 RCTs with 1345 participants. The Samryungbaekchul-san treatment group had a significantly higher total effective rate (TER) than that of the western medicine control group (RR 1.42, 95% CI 1.23–1.64, I 2 = 0%). The combined Samryungbaekchul-san and western medicine treatment group had significantly higher TER (RR 1.31, 95% CI 1.23 to 1.40, I2 = 0%) and levels of neuropeptide Y (SMD 0.93, 95% CI 0.47–1.39, I 2 = 70%) and ghrelin (SMD 1.45, 95% CI 1.14–1.76, I2 = 0%) than those of the western medicine alone group. Additionally, leptin levels were significantly lower in the combined treatment group (SMD -1.19, 95% CI -1.88 to -0.51, I2 = 86%) compared with the western medicine alone group, although statistical heterogeneity was substantial. Conclusions Samryungbaekchul-san may be effective for childhood anorexia. However, owing to limitations such as high clinical heterogeneity between the studies, unclear risks of biases, and insufficient reports of adverse events and follow-ups, well-designed RCTs with a low risk of bias are needed in the future.

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관련 논문AI추천

소아 식욕부진에 대한 이공산(異功散) 치료의 효과: 체계적 문헌고찰 및 메타분석박상은, 이보람, 이선행, 장규태, 하다정, 허태영대한한방내과학회 · 대한한방내과학회지2022 · 제43권 제4호소아의 식욕부진에 대한 한약치료의 최신 임상연구 동향 -중국 RCT 연구를 중심으로-박용석, 신혜진, 이지홍, 장규태대한한방소아과학회 · 대한한방소아과학회지2019 · 제33권 제4호소아 식욕부진의 병인, 변증, 치료에 대한 고찰 -중의학 논문을 중심으로-김혜연, 박슬기, 서혜선, 이선행, 이진용, 장규태대한한방소아과학회 · 대한한방소아과학회지2022 · 제36권 제1호소아 식욕부진의 한의표준임상진료지침 개발을 위한 델파이 연구방미란, 이선행, 장규태대한한방소아과학회 · 대한한방소아과학회지2024 · 제38권 제2호소아 식욕부진의 한의표준임상경로 개발 및 시범 적용 연구방미란, 장규태, 정윤경, 최서연대한한방소아과학회 · 대한한방소아과학회지2023 · 제37권 제3호소아 거식증 (Infantile Anorexia)의 韓醫學적 치료에 관한 고찰- 中醫學 저널을 중심으로 -김기봉, 김희연, 성우용대한한방소아과학회 · 대한한방소아과학회지2013 · 제27권 제4호

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