Pharmaceutical Drug Poisoning after Deregulation of Over the Counter Drug Sales: Emergency Department Based In-depth Injury Surveillance
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Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation of OTC drug sales. Methods: This study analyzed the data of Emergency Department based Injury In-depth Injury Surveillance (EDIIS), Korea Centers for Disease Control and Prevention, from 2011 to 2014. The following items were examined: age, gender, intention, alcohol association, pharmaceutical drugs resulting acute poisoning, the clinical outcomes in emergency department, and the admission rate of intensive care unit (ICU). This is a retrospective cross section observational study. Results: A total of 10,162 patients were subject to pharmaceutical drug poisoning. Acute poisoning by acetaminophen and other drugs were 1,015 (10.0%) and 9,147 (90.0%) patients, respectively. After the deregulation of OTC drug sales, acute poisoning by other drugs increased from 4,385 to 4,762 patients but acute poisoning by acetaminophen decreased from 538 to 477 patients (p<0.05). The rate of admission of acetaminophen poisoning increased from 36.1% (194/538) to 46.8% (223/477). The admission rate to the ICU by acetaminophen poisoning increased from 4.6% (25/538) to 11.3% (54/477) after the deregulation of OTC drug sales (p<0.05). Conclusion: Since the deregulation of OTC drugs sales, pharmaceutical drug poisoning has increased but acetaminophen poisoning has decreased. The rate of hospitalization and ICU admission by pharmaceutical drug poisoning with or without acetaminophen has also increased.
Abstract
Purpose: The Korean government approved selected nonprescription drugs (Over-The-Counter drug; OTC drug) to be distributed in convenience stores from 15. Nov. 2012. This study examined the changes in the incidence and the clinical outcome of acute pharmaceutical drug poisoning after the deregulation of OTC drug sales. Methods: This study analyzed the data of Emergency Department based Injury In-depth Injury Surveillance (EDIIS), Korea Centers for Disease Control and Prevention, from 2011 to 2014. The following items were examined: age, gender, intention, alcohol association, pharmaceutical drugs resulting acute poisoning, the clinical outcomes in emergency department, and the admission rate of intensive care unit (ICU). This is a retrospective cross section observational study. Results: A total of 10,162 patients were subject to pharmaceutical drug poisoning. Acute poisoning by acetaminophen and other drugs were 1,015 (10.0%) and 9,147 (90.0%) patients, respectively. After the deregulation of OTC drug sales, acute poisoning by other drugs increased from 4,385 to 4,762 patients but acute poisoning by acetaminophen decreased from 538 to 477 patients (p<0.05). The rate of admission of acetaminophen poisoning increased from 36.1% (194/538) to 46.8% (223/477). The admission rate to the ICU by acetaminophen poisoning increased from 4.6% (25/538) to 11.3% (54/477) after the deregulation of OTC drug sales (p<0.05). Conclusion: Since the deregulation of OTC drugs sales, pharmaceutical drug poisoning has increased but acetaminophen poisoning has decreased. The rate of hospitalization and ICU admission by pharmaceutical drug poisoning with or without acetaminophen has also increased.
참고문헌 (18)
- Association CHP, "The value of OTC medicine to the United States" (2012), Consumer Healthcare Products Association
- Dudley JW, "OTC distribution in Europe" (2010), James Dudley International Ltd
- Domestic and international cases of improvement in regulations concerning general pharmaceuticals, , Korea Chamber of Commerce and Industry, ~ (2009)
- 박형욱, "안전상비의약품 약국 외 판매의 의의와 과제", 대한의사협회지, 55(9), pp.843~851 (2012), 대한의사협회
- Pre-Announcement of Legislation of Enforcement Ordinances and Enforcement Regulations of Pharmaceutical Law, , The Press Release of the Minister of Health and Welfare, ~ (2012)
- 김은희, "일반의약품 약국 외 판매 이후의 일반의약품 정책에 대한 소비자의 인식 변화", 한국임상약학회지, 24(3), pp.183~192 (2014), 한국임상약학회
- 김희호, "일반의약품 약국외(슈퍼) 판매 시행 전후 약국에서의 전환 품목 매출추이 분석", 석사, 제약산업학과, pp.2014
- Lee KH, "Clinical analysis of acute drug intoxication in the emergency department", J Korean Soc Emerg Med, 7, pp.398~404 (1996)
- Kang JH, "A clinical analysis of acute drug intoxication in emergency department setting", J Korean Soc Emerg Med, 10, pp.431~440 (1999)
- Sung AJ, "Multicenter Survey of Intoxication Cases in Korean Emergency Departments : 2nd Annual Report", J Korean Soc Clin Toxicol, 10, pp.22~32 (2012)
- Smilkstein MJ, "Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose", New England Journal of Medicine, 319, pp.1557~1562 (1988)
- Chung SP, "Acetaminophen poisoning", J Korean Soc Clin Toxicol, 6, pp.1~8 (2008)
- Perry S, "Ibuprofen overdose : the first two years of over-the-counter sales", Human Toxicology, 6, pp.173~178 (1987)
- Wazaify M, "Prevalence of over-the-counter drug-related overdoses at Accident and Emergency departments in Northern Ireland-a retrospective evaluation", Journal of clinical pharmacy and therapeutics, 30, pp.39~44 (2005)
- Hawkins MLC, "Impact of restricting paracetamol pack sizes on paracetamol poisoning in the United Kingdom", Drug safety, 30, pp.465~479 (2007)
- Chan TY, "Safety packaging of acetaminophen combination preparations and severity of adult poisoning", Journal of Toxicology : Clinical Toxicology, 34, pp.747~749 (1996)
- "Article 44-4 of Pharmaceutical Affairs Act", ~ (2012)