메스암페타민(필로폰) 급성 중독으로 유발된 심정지 후 생존한 1례
Survival after Cardiac Arrest due to Acute Methamphetamine Poisoning: A Case Report
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Drug abuse and its related problems are increasing continuously in Korea. One of the most frequently abused drugs is methamphetamine, but there are few medical report in Korea. This is the first report of the identification of methamphetamine in the blood of a patient who had a return of spontaneous circulation after cardiac arrest and survived discharge. A 33-year-old male arrived at the emergency department presenting with chest pain and dyspnea. He had ingested methamphetamine and alcohol approximately 7 hours before arrival. One hour after arrival, he had seizure followed by cardiac arrest. Spontaneous circulation was recovered after 4 minutes of CPR. An analysis of the National Forensic Service identified plasma methamphetamine with an estimated average concentration of plasma methamphetamine at the time of arrival of 0.6 mg/L, a lethal dose. He had rhabdomyolysis and acute kidney injury but survived after continuous renal replacement therapy. Since then, he has suffered chronic kidney disease, and he is being followed up at the out-patient department. In Korea, although drug abuse is still uncommon, it is on the increase.
Abstract
Drug abuse and its related problems are increasing continuously in Korea. One of the most frequently abused drugs is methamphetamine, but there are few medical report in Korea. This is the first report of the identification of methamphetamine in the blood of a patient who had a return of spontaneous circulation after cardiac arrest and survived discharge. A 33-year-old male arrived at the emergency department presenting with chest pain and dyspnea. He had ingested methamphetamine and alcohol approximately 7 hours before arrival. One hour after arrival, he had seizure followed by cardiac arrest. Spontaneous circulation was recovered after 4 minutes of CPR. An analysis of the National Forensic Service identified plasma methamphetamine with an estimated average concentration of plasma methamphetamine at the time of arrival of 0.6 mg/L, a lethal dose. He had rhabdomyolysis and acute kidney injury but survived after continuous renal replacement therapy. Since then, he has suffered chronic kidney disease, and he is being followed up at the out-patient department. In Korea, although drug abuse is still uncommon, it is on the increase.
참고문헌 (14)
- "Annual prevalence of the use of cannabis, cocaine, opioids, opiates, amphetamine-type stimulants and “ecstasy” by region and globally" (2016)[URL]
- "drug crime white paper" (2017)[URL]
- Skinner HF, "Methamphetamine synthesis via hydriodic acid", red phosphorus reduction of ephedrine, 1990, pp.48, 123~134
- Puja Seth, "Overdose Deaths Involving Opioids, Cocaine, and Psychostimulants — United States, 2015–2016", MMWR. Morbidity and Mortality Weekly Report, 67(12), pp.349~358 (2018), Centers for Disease Control MMWR Office[DOI]
- "Desoxyn Prescribing Information" (2014)[URL]
- Lineberry TW, "Methamphetamine Abuse : A Perfect Storm of Complications", Mayo Clinic Proceedings, 81, pp.77~84 (2006)
- Paratz ED, "The Cardiac Complications of Methamphetamines", Heart, Lung and Circulation, 25(4), pp.325~332 (2016)
- Chyka PA, "American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Position paper:single-dose activated charcoal", Clin Toxicol(Phila), 43, pp.61~87 (2005)
- Kalant H, "Death in amphetamine users: causes and rates", Can Med Assoc J, 112(3), pp.299~304 (1975)
- Starcevic B, "Dual intoxication with diazepam and amphetamine: this drug interaction probably potentiates myocardial ischemia", Medical Hypotheses, 69, pp.377~380 (2007)
- Lebish P, "Determination of amphetamine, methamphetamiue, and related amines in blood and urine by gas chromatography with hydrogen flame ionization detection", Clin Chem, 16, pp.195~200 (1970)
- Logan BK., "Cause and manner of death in fatalities involving methamphetamine", J Forensic Sci, 43, pp.28~34 (1998)
- Yamamura T, "Alcohol addiction of methamphetamine abusers in Japan", J Forensic Sci, 36, pp.754~764 (1991)
- "Emergency Department Visits Involving Methamphetamine: 2007 to 2011" (2014)[URL]