Isolation of 6,6’-Bieckol from Grateloupia elliptica and its Antioxidative and Anti-Cholinesterase Activity
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During the search for anticholinesterase compounds from marine organisms, we were able to isolate 6,6’-bieckol from a red alga, Grateloupia elliptica. This compound showed moderate acetylcholinesterase (AChE) inhibitory activity in a micromole range (IC50 44.5 μM). However, for butyrylcholinesterase (BuChE), a new target for the treatment of Alzheimer’s disease (AD), it showed particularly potent inhibitory activity (IC50 27.4 μM), which is more potent compared to AChE. It also inhibits BACE-1, a new target for reducing the generation of β-amyloid.
Abstract
During the search for anticholinesterase compounds from marine organisms, we were able to isolate 6,6’-bieckol from a red alga, Grateloupia elliptica. This compound showed moderate acetylcholinesterase (AChE) inhibitory activity in a micromole range (IC50 44.5 μM). However, for butyrylcholinesterase (BuChE), a new target for the treatment of Alzheimer’s disease (AD), it showed particularly potent inhibitory activity (IC50 27.4 μM), which is more potent compared to AChE. It also inhibits BACE-1, a new target for reducing the generation of β-amyloid.
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