태지유사지질복합체의 제조와 특성
Preparation and Characterization of Vernix Caseosa Analogues
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Vernix caseosa is the creamy white skin surface biofilm which covers the skin of the fetus and the newborn. A recent human clinical study demonstrated that vernix caseosa has skin moisturizing and skin barrierenhancing properties. The aim of this study was to develop vernix caseosa analogues mimicking the uniquestructure and properties of natural vernix caseosa. The vernix caseosa mimetic formulations were preparedusing high internal phase water-in-oil emulsion with skin barrier lipids, skin surface (sebaceous) lipids, cosurfactantsand emulsion stabilizers. Stability studies of these vernix caseosa mimetics were carried outat different storage conditions for 28days. Subsequently, we have investigated whether topical applicationof vernix caseosa mimetic (VCM Ⅷ) improve the water content of the skin surface and accelerate therecovery of the skin barrier. Our results showed that VCM Ⅷ improved the skin moisturization comparedwith W/O cream and O/W DMS cream. Moreover, Observation at five minutes after application of the testmaterials (vaseline, DMS cream and VCM Ⅷ) showed that the baseline water content of all samples werebetter than with control normal skin. After applying drops of water on the testing areas and wiping them off,DMS cream obtained the highest hygroscopicity (69.77), followed by VCM Ⅷ (68.17). But VCM Ⅷ showedhigh stability according to the water-holding capacity patterns observed after 10 minutes. Finally, VCM Ⅷshowed a significant improvement of barrier recovery (58.3%) after 3 days compared with vaseline (50.4%)and physiological lipid mixture (37.2%). The rate of barrier recovery was also greater for the VCM Ⅷ (101.8%)than skin barrier lipid mixture (76.3%) and vaseline (90.6%) on day 7. These studies show that vernixcaseosa analogue can both accelerate skin barrier recovery and enhance stratum corneum moisturization.
Abstract
Vernix caseosa is the creamy white skin surface biofilm which covers the skin of the fetus and the newborn. A recent human clinical study demonstrated that vernix caseosa has skin moisturizing and skin barrierenhancing properties. The aim of this study was to develop vernix caseosa analogues mimicking the uniquestructure and properties of natural vernix caseosa. The vernix caseosa mimetic formulations were preparedusing high internal phase water-in-oil emulsion with skin barrier lipids, skin surface (sebaceous) lipids, cosurfactantsand emulsion stabilizers. Stability studies of these vernix caseosa mimetics were carried outat different storage conditions for 28days. Subsequently, we have investigated whether topical applicationof vernix caseosa mimetic (VCM Ⅷ) improve the water content of the skin surface and accelerate therecovery of the skin barrier. Our results showed that VCM Ⅷ improved the skin moisturization comparedwith W/O cream and O/W DMS cream. Moreover, Observation at five minutes after application of the testmaterials (vaseline, DMS cream and VCM Ⅷ) showed that the baseline water content of all samples werebetter than with control normal skin. After applying drops of water on the testing areas and wiping them off,DMS cream obtained the highest hygroscopicity (69.77), followed by VCM Ⅷ (68.17). But VCM Ⅷ showedhigh stability according to the water-holding capacity patterns observed after 10 minutes. Finally, VCM Ⅷshowed a significant improvement of barrier recovery (58.3%) after 3 days compared with vaseline (50.4%)and physiological lipid mixture (37.2%). The rate of barrier recovery was also greater for the VCM Ⅷ (101.8%)than skin barrier lipid mixture (76.3%) and vaseline (90.6%) on day 7. These studies show that vernixcaseosa analogue can both accelerate skin barrier recovery and enhance stratum corneum moisturization.
참고문헌 (24)
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