용해도 개선을 위한 레보설피라이드 무정형 분무 건조 미세분말의 제조 및 평가
Fabrication and Evaluation of Levosulpiride-loaded Amorphous Spray-dried Microparticle for Improved Solubility
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초록
The purpose of this study is to develop and evaluate amorphous spray-dried microparticles (SDM) containing levosulpiride to increase its solubility. SDM are prepared via solvent evaporation using polyvinylpyrrolidone (PVP) as the water-soluble polymer and Cremophor RH40 as the surfactant. The SDM is prepared by varying the amounts of PVP and Cremophor RH40, and its physicochemical properties, solubility, and dissolution are confirmed. All levosulpiride-loaded SDMs converted the crystalline drug into an amorphous form, significantly improving drug solubility and dissolution compared with the drug alone. SDM consisting of drug/PVP/Cremophor RH40 in a weight ratio of 5:10:3, with increased solubility (720 ± 36 vs. 1822 ± 51 μg/mL) and dissolution rate (10.3 ± 2.2 vs. 92.6 ± 6.0%) compared with drug alone, shows potential as a commercial drug for improved oral bioavailability of levosulpiride.
Abstract
The purpose of this study is to develop and evaluate amorphous spray-dried microparticles (SDM) containing levosulpiride to increase its solubility. SDM are prepared via solvent evaporation using polyvinylpyrrolidone (PVP) as the water-soluble polymer and Cremophor RH40 as the surfactant. The SDM is prepared by varying the amounts of PVP and Cremophor RH40, and its physicochemical properties, solubility, and dissolution are confirmed. All levosulpiride-loaded SDMs converted the crystalline drug into an amorphous form, significantly improving drug solubility and dissolution compared with the drug alone. SDM consisting of drug/PVP/Cremophor RH40 in a weight ratio of 5:10:3, with increased solubility (720 ± 36 vs. 1822 ± 51 μg/mL) and dissolution rate (10.3 ± 2.2 vs. 92.6 ± 6.0%) compared with drug alone, shows potential as a commercial drug for improved oral bioavailability of levosulpiride.
참고문헌 (23)
- D. S. Kim, , Int. J. Pharm, 511, pp.351~ (2016)
- D. S. Kim, , Colloids Surf. B Biointerfaces, 147, pp.250~ (2016)
- S. T. Arif, , Pharmaceutics, 14, pp.2347~ (2022)
- N. Khaleeq, , J. Microencapsul, 37, pp.1600~ (2020)
- F. Din, , Pharm. Dev. Technol, 24, pp.63~ (2019)
- 김동식, "Influence of Hydroxypropylmethylcellulose and Sodium Lauryl Sulfate on the Solubility and Dissolution of Sirolimus in Solvent‐evaporated Solid Dispersions", Bulletin of the Korean Chemical Society, 39(6), pp.778~783 (2018), 대한화학회[DOI]
- M. J. Choi, , Int. J. Mol. Sci, 23, pp.9491~ (2022)
- P. Pandi, , Int. J. Pharm, 586, pp.119560~ (2020)
- J. S. Kim, , Carbohydr. Polym, 271, pp.118433~ (2021)
- J. S. Kim, , Int. J. Nanomedicine, 16, pp.5797~ (2021)
- J. E. Choi, , Int. J. Pharm, 597, pp.120377~ (2021)
- M. J. Choi, , J. Mol. Liq, 346, pp.117057~ (2021)
- A. S. Han, , J. Drug Deliv. Sci. Technol, 70, pp.103213~ (2022)
- W. Kim, , J. Drug Deliv. Sci. Technol, 66, pp.102877~ (2021)
- M. M. Ghobashy, , ACS Omega, 5, pp.21476~ (2020)
- S. A. Helmy, , Ther. Deliv, 11, pp.447~ (2020)
- F. Febriyenti, , J. Pharm. Bioallied Sci, 11, pp.262~ (2019)
- H. Yin, , Plos One, 17, pp.e0263692~ (2022)
- J. E. Choi, , J. Drug Deliv. Sci. Technol, 76, pp.103803~ (2022)
- S. Dedroog, , J. Pharm. Biomed. Anal, 178, pp.112937~ (2020)
- X. Ma, , J. Drug Deliv. Sci. Technol, 50, pp.113~ (2019)
- S. Saboo, , Mol. Pharm, 17, pp.1261~ (2020)
- A. B. Anane-Adjei, , Int. J. Pharm, 614, pp.121387~ (2022)