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복합생약추출물이 고지방식이를 급여한 쥐의 비만 억제에 미치는 영향

Effect of Combined Plant Extracts on Anti-obesity in Rats Fed a High-Fat Diet

이혜숙|박종배|황석연|홍승복|김희동|윤치영
한국피부과학연구원 (Korea Institute of Dermatological Sciences)|2011.02|아시안뷰티화장품학술지 (Asian Journal of Beauty and Cosmetology)|제9권 제1호|pp. 25-34

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참고문헌

키워드

high fat diet중성지방triglyceride복합생약추출물고지방식이콜레스테롤combined plant extractscholesterol
주제분류미용

초록

본 연구는 고지방식이로 비만이 유도된 흰쥐에서 복합생약추출물로 인한 체중, 혈청 지질 대사 개선 및 항비만에 미치는 효과를 살펴보기 위하여 4주령 된 흰쥐 수컷 50마리를 정상식이군(ND), 고지방식이군(HFD), 고지방식이와 복합생약추출물 급여군(HFD+1%, 3%, 5%)군으로 나누어 8주간 실시하였다. 정상식이군과 비교하여 고지방식이군은 체중이 증가하였고, 복합생약추출물을 첨가한 시험물질 급여군은 6주 이후 체중 증가가 억제되었다. 고지방식이로 증가되어진 혈청 중의 AST 활성, 중성지방, LDL-콜레스테롤 함량도 복합생약추출물을 첨가한 시험물질 급여로 감소되었다. 혈청 중 ALT 활성, ALP 활성은 실험군 간에 유의한 차가 없었다. 혈청 중의 총콜레스테롤 함량은 감소하는 경향을 나타내었지만 유의성은 나타나지 않았고, HDL-콜레스테롤 함량은 정상식이군에 비하여 감소하는 경향을 나타내었지만 고지방식이와 복합생약추출물을 혼합투여 하였을 경우에는 현저한 영향을 미치지 않는 것으로 나타났다. 이러한 결과들로부터 복합생약추출물의 비만 억제 효과를 관찰할 수 있었고, 향후 보다 심층 있는 연구를 통하여 비만 관련 의약품, 건강기능성 식품의 소재로써 활용될 수 있을 것으로 사료된다.

Abstract

This study was conducted to investigate the anti-obesity of combined plant extracts(Mori folium and Mori cortex radicis, 7:3) in male Sprague-Dawley rats(180 ± 3 g) fed high fat diets for 8 week. Experimental groups were divided into 5 groups; a normal diet group(ND), a high fat diet group(HFD), a high fat diet and combined plant extracts 1% group(HFD+ 1%), a high fat diet and combined plant extracts 3% group(HFD+3%) and a high fat diet and combined plant extracts 5% group(HFD+5%). The body weight of HFD group were heavier than those of ND group, whereas those of groups administered combined plant extracts were gradually decreased after 6 weeks. The activity of serum AST that were significantly increased by the high fat diet were significantly decreased after combined plant extracts administration. Levels of serum triglyceride and LDL-cholesterol significantly reduced in the combined plant extracts administered groups compared with HFD group. There were no differences in the levels of serum total cholesterol and HDL-cholesterol between experimental groups. Theses results suggest that combined plant extracts may inhibit obesity in rat fed HFD.

참고문헌 (25)

  1. 보건사회부, "대한약전 제 3개정", pp.734~ (1976), 세문사
  2. Atkinson RL, "Use of drugs in the treatment of obesity", Annu. Rev. Nutr, 17, pp.383~403 (1997)
  3. Carmichael AR, "Treatment for morbid obesity", Postgrad. Med. J, 75(879), pp.7~12 (1999)
  4. Colditz GA, "Weight as a risk factor for clinical diabetes in women", Am. J. Epidemiol, 132(3), pp.501~513 (1990)
  5. Davignon J, "Triglycerides: a risk factor for coronary heart disease", Atherosclerosis, 124(1), pp.S57~S64 (1996)
  6. Flegal KM, "Prevalence and trends in obesity among US adults, 1999-2000", JAMA, 288(14), pp.1723~1727 (2002)
  7. Fujimoto T, "Components of root bark of cudrania tricuspidata 3. Isolation and structure studies on the flavonoids", Planta. Med, 51, pp.190~196 (1985)
  8. Gaíva MH, "Polyunsaturated fatty acid-rich diets: effect on adipose tissue metabolism in rats", Br. J. Nutr, 86(3), pp.371~377 (2001)
  9. Hong SH, "Anti-Obesity Effect of Mulberry Root-Bark (Mori radicis Cortex) in Zucker Rats with High Lipid Diet Induced-Obesity", Clin. Lab. Sci, 37(2), pp.129~137 (2005)
  10. Huang Z, "Body weight, weight change, and risk for hypertension in women", Ann. Intern. Med, 128(2), pp.81~88 (1998)
  11. Juhel C, "Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro", J. Nutr. Biochem, 11(1), pp.45~51 (2000)
  12. Kim HB, "Effect of methanol extract from mulberry fruit on the lipid metabolism and liver function in cholesterol-induced hyperlipidemia rats", Korean J. Seri. Sci, 43(2), pp.104~108 (2003)
  13. Kim HM, "Immunomodulating activity of a polysaccharide isolated from Mori cortex radicis", Arch.. Pharm. Res, 23(3), pp.240~242 (2000)
  14. Kim SY, "Anti-inflammatory and antioxidative effects of Morus spp. fruit extract", Korean J. Med. Crop. Sci, 6(3), pp.204~209 (1998)
  15. Kondo Y, "Trace constituents of mulberry leaves", Nippon Sanshigaku Zasshi, 26, pp.349~353 (1957)
  16. Kwon CS, "Induction of cellular quinone reductase by some flavonoids", Food Sci. Biotechnol, 12(6), pp.649~653 (2003)
  17. Löest HB, "Green tea extract inhibits the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats", J. Nutr, 132(6), pp.1282~1288 (2002)
  18. Manson JE, "Body Weight and mortality among women", N. Engl. J. Med, 333(11), pp.677~685 (1995)
  19. Park JH, "The encyclopedia of chinese crude drugs", Shinil sangsa, Seoul, Korea. Mori Fructus, pp.412~422 (2002)
  20. Plaa GL, "Detection and evaluation of chemically induced liver injury. In Principles and Methods of Toxicology", pp.839~870 (1994), Raven Press
  21. Prentice AM, "Obesity and its potential mechanistic basic", Brit Med Bull, 60(1), pp.51~67 (2001)
  22. Jae Myun Ryu, "Improvement Effect of Mulberry Root-Bark (Mori radicis Cortex) Water Extract on Atherosclerosis in Hypercholesterolemic Rabbits", Laboratory Animal Research, 22(1), pp.83~89 (2006), 한국실험동물학회
  23. Wang HK, "The therapeutic potential of flavonoids", Expert Opin Investig Drugs, 9(9), pp.2103~2119 (2000)
  24. The World Health Report: Reporting Risks, "WHO", Promoting Healthy Life, 59~ (2002)
  25. Yang CS, "Inhibition of carcinogenesis by dietary polyphenolic compounds", Annu. Rev. Nutr, 21, pp.381~406 (2001)

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