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인진호 추출물의 항산화활성 및 항염효과

Anti-oxidative and Anti-inflammatory Effects of Artemisiae Capillaris Extract

김금란|김정숙
한국피부과학연구원 (Korea Institute of Dermatological Sciences)|2015.12|아시안뷰티화장품학술지 (Asian Journal of Beauty and Cosmetology)|제13권 제6호|pp. 805-812

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키워드

Anti-inflammatoryCosmeceuticalAnti-oxidantArtemisiae Capillaris Herba
주제분류미용

초록

This study was designed to evaluate the applicability as active ingredient in cosmeceutical products by examining a variety of physiological activities with the extract of Artemisiae Capillaris (AC). AC is a plant grown in Korea, which has been widely used as an oriental medicinal herb and folks remedy to treat jaundice, hepatitis and liver diseases. "Cosmeceuticals is a fusion of the terms "cosmetic" and "pharmaceutical". The cosmetic market for cosmeceutical products is growing at a faster rate. The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to anti-aging, atopic dermatitis, psoriasis, acne etc. This experiment was to investigate anti-oxidant and anti-inflammatory effect with a 80% ethanol extract from AC. To investigate antioxidant effect, we performed DPPH and ABT assay and evaluated the levels of total phenolics and flavonoids. DPPH and ABTS radical scavenging activities significantly increased in a AC concentration-dependent manner. The measured total polyphenol content of AC was 419.7mg/g. In anti-inflammation experiment, AC demonstrated a strong anti-inflammatory activity that induced inhibition of NO and PGE2 production in the LPS-stimulated inflammatory response in RAW 264.7 macrophages. Based on the results in this study, the AC show that the possibilities of utilizing AC extracts as a functional active ingredient for anti-oxidation and anti-inflammation in cosmeceutical products and it could be developed as components of cosmetics.

Abstract

This study was designed to evaluate the applicability as active ingredient in cosmeceutical products by examining a variety of physiological activities with the extract of Artemisiae Capillaris (AC). AC is a plant grown in Korea, which has been widely used as an oriental medicinal herb and folks remedy to treat jaundice, hepatitis and liver diseases. "Cosmeceuticals is a fusion of the terms "cosmetic" and "pharmaceutical". The cosmetic market for cosmeceutical products is growing at a faster rate. The antioxidant and anti-inflammatory effects of active ingredients in cosmetics are very important. The effects are closely related to anti-aging, atopic dermatitis, psoriasis, acne etc. This experiment was to investigate anti-oxidant and anti-inflammatory effect with a 80% ethanol extract from AC. To investigate antioxidant effect, we performed DPPH and ABT assay and evaluated the levels of total phenolics and flavonoids. DPPH and ABTS radical scavenging activities significantly increased in a AC concentration-dependent manner. The measured total polyphenol content of AC was 419.7mg/g. In anti-inflammation experiment, AC demonstrated a strong anti-inflammatory activity that induced inhibition of NO and PGE2 production in the LPS-stimulated inflammatory response in RAW 264.7 macrophages. Based on the results in this study, the AC show that the possibilities of utilizing AC extracts as a functional active ingredient for anti-oxidation and anti-inflammation in cosmeceutical products and it could be developed as components of cosmetics.

참고문헌 (45)

  1. 강경명, "추출 방법에 따른 쑥 추출물의 항산화 활성", 한국식품영양과학회지, 42(8), pp.1249~1254 (2013), 한국식품영양과학회
  2. 권훈정, "식물성 일반식품 자원의 에탄올 추출물이 염증 효소계에 미치는 영향", 한국식품과학회지, 39(3), pp.348~352 (2007), 한국식품과학회
  3. 길영기, "인진추출물이 lipopolysaccharide 주입에 의한 흰쥐 간의 염증반응에 미치는 혈청학적 및 면역조직화학적 영향", 생명과학회지, 14(2), pp.215~220 (2004), 한국생명과학회
  4. 김민석, "백렴약침액이 대식세포에서 NO와 Prostaglandin 생성에 미치는 영향", 대한침구의학회지, 27(3), pp.65~73 (2010), 대한침구의학회
  5. 김승현, "승마, 우슬, 인진호, 목단피 및 빈랑자의 독성연구를 위한 안정성 시험", 생약학회지, 39(3), pp.241~245 (2008), 한국생약학회
  6. 김시나, "인진 추출물의 소염진통작용", 생약학회지, 36, pp.338~343 (2005)
  7. 김예진, "산양삼(Korean Panax ginseng) 추출물의 항산화 효과 및 LPS로 염증이 활성화된 RAW 264.7 대식세포에서의 염증매개물질 억제효과", 한국식품영양과학회지, 41(10), pp.1371~1377 (2012), 한국식품영양과학회
  8. 김홍태, "인진쑥 추출물의 세포독성 효과", 한국임상수의학회지, 24(3), pp.367~371 (2007), 한국임상수의학회
  9. 김홍태, "고지방 사료 급여 마우스에서 인진쑥 추출물의 항비만 효과", 한국임상수의학회지, 27(4), pp.348~365 (2010), 한국임상수의학회
  10. 남진주, "각질형성세포에서 ROS로 유도된 염증반응에 대한 능실추출물 및 그 분획물의 항염 효과", 대한화장품학회지, 41(1), pp.45~55 (2015), 대한화장품학회[DOI]
  11. 서용석, "茵蔯蒿가 LPS 염증유발 흰쥐의 전염증성 cytokine 생산 및 혈액성상에 미치는 영향", 한방재활의학과학회지, 20(3), pp.27~35 (2010), 한방재활의학과학회
  12. 오미현, "In vitro 및 In vivo에서 인진쑥 추출물이 장내미생물에 미치는 영향", 한국식품영양과학회지, 39(11), pp.1587~1594 (2010), 한국식품영양과학회
  13. 유근형, "에탄올 투여 랫트에서 인진쑥 열수 추출물이 간 독성 저하에 미치는 영향", 한국식품영양과학회지, 42(10), pp.1560~1566 (2013), 한국식품영양과학회
  14. 이형자, "사철쑥(Artemisia capillaris Thunberg)의 영양성분 분석", 한국식품영양과학회지, 31(3), pp.361~366 (2002), 한국식품영양과학회
  15. 이형자, "사철쑥의 HeLa 세포고사 효과", Journal of Nutrition and Health, 41(1), pp.22~30 (2008), 한국영양학회
  16. 임현희, "천궁 및 당귀를 함유한 한방처방제 휘발성 향기추출물의 항염증 효과", 대한화장품학회지, 37(3), pp.199~210 (2011), 대한화장품학회
  17. 정미정, "인진쑥 추출물의 항산화 및 항암 활성", 생약학회지, 39(3), pp.194~198 (2008), 한국생약학회
  18. 정수지, "열풍건조 삼채의 분획별 미백 및 항산화 활성에 관한 연구", 한국식품영양과학회지, 44(6), pp.832~839 (2015), 한국식품영양과학회
  19. 정향숙, "불가사리 유래 콜라겐 펩타이드의 피부 면역 증진 효과", 한국식품과학회지, 40(5), pp.522~527 (2008), 한국식품과학회
  20. 지나, "HaCaT 피부각질세포에서 들깻잎 추출물의 산화적 스트레스에 대한 항산화 효과", 한국식품영양과학회지, 42(2), pp.161~167 (2013), 한국식품영양과학회
  21. Abdullah Bin Junaid, "A comparative analysis of male and female consumer behaviour factors for their cosmeceutical products rypes", J. Account Mark, 4 (2015)
  22. Andreas Kuehne, "Acute Activation of Oxidative Pentose Phasphate Pathway as Fist-Line Response to Oxidative Stress in Human Skin Cells", Molecular Cell, 59, pp.1~13 (2015)
  23. Christian Oplander, "The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-induced Cell Death", Int. J. Mol. Sci, 14, pp.191~204 (2013)
  24. Colin D. Funk, "Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology", Science, 294, pp.1878~1875 (2001)
  25. Gillbro JM, "The melanogenesis and mechanisms of skin-lightening agents-existing and new approaces", Int. J. Cosmet. Sci, 33, pp.210~221 (2011)
  26. Gutfinger T., "Polyphenols in olive oils", J. Am. Oil. Chem. Soc, 58, pp.966~968 (1981)
  27. 황인식, "UV조사에 의해 유도된 피부섬유아세포의 세포사에 미치는 Sea Buckthorn (Hippophae rhamnoides L.) 열매추출물의 영향", 생명과학회지, 24(5), pp.467~475 (2014), 한국생명과학회
  28. Kammeyer A, "Oxidation events and skin aging", Ageing Res. Rev, 21, pp.16~29 (2015)
  29. Khalid O Abulnaja, "Oxidant", Antioxidant status in obese adolescent females with Acne Vulgaris, 2009, pp.54, 36~40
  30. 김영훈, "신이화(辛夷花, Magnoliae Flos)추출물의 화장품약리활성 및 항염증효과에 관한 연구", 생명과학회지, 22(6), pp.730~735 (2012), 한국생명과학회[DOI]
  31. Kozina LS, "Role of Oxidative Stress in Skin Aging", Advances in Gerontology, 3, pp.18~22 (2013)
  32. Kwon MJ, "Role of superoxide dismutase 3 in skin inflammation", J. Dermatol. Sci, 67, pp.81~87 (2012)
  33. Ozer Arican, "Oxidative Stress in Patients With Acne Vulgaris", Mediators of Inflammation, 6, pp.380~384 (2005)
  34. Singhal Mukul, "Cosmeceuticals for the skin: An overview", Asian J. Pharm. Clin. Res, 4, pp.1~6 (2011)
  35. Liou JY, "Cyclooxygenase-2-Derived Prostaglandin E2 Protects Mouse Embryonic Stem Cells from Apoptosis", Stem Cells, 25, pp.1096~1103 (2007)
  36. Nieva M, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina", J. Ethnopharmacol, 71, pp.109~114 (2000)
  37. Rhie GE, "Aging-and Photoaging-Dependent Changes of Enzymic and Nonenzymin Antioxidants in the Epidermis and Dermis of Human Skin In Vivo", The Soc. Investigative Dermatol, 17, pp.1212~1217 (2001)
  38. Tomas C. Tsai, "Cosmeceutical Agents:A Comprehensive Review of the Literature", Clin. Med. Dermatol, 1, pp.1~20 (2008)
  39. Toshinori Bito, "Impact of reactive oxygen species on kirationcyte signaling pathways", J. Dermatol. Sci, 68, pp.3~8 (2012)
  40. Yan Peng, "Stem cells and aberrant signaling of molecular systems in skin aging", Ageing Research Review, 19, pp.8~21 (2015)
  41. 윤지훈, "백급(Bletilla striata Reichenbach fil.) 분획물의 항산화, 항염증 효과와 화장품소재로서의 연구", 생명과학회지, 23(9), pp.1073~1078 (2013), 한국생명과학회[DOI]
  42. Yun KJ, "Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways", Int. Immunopharmacol, 8, pp.431~441 (2008)
  43. 윤준용, "강화사자발쑥의 마크로파지 RAW 264.7세포에 대한 Tumor Necrosis Factor-α, Prostaglandin E2, Cyclooxygenase-2 및 LPS 유도 Nitric Oxide 생성 저해", 한국약용작물학회지, 16(5), pp.326~331 (2008), 한국약용작물학회
  44. Zillich OV, "Polyphenols as active ingredients for cosmetic products", Int. J. Cosmet. Sci, pp.1~10 (2015)
  45. Zoe Diana Draelos, MD, "The latest cosmeceutical approaches for anti-aging", J. cosmet. Dermatol, 6, pp.2~6 (2007)

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