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다발성 골수종 환자에서 발생한 혈소판 기능 장애

Platelet Dysfunction in a Patient with Multiple Myeloma: A Case Report with a Literature Review

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초록

Multiple myeloma is a monoclonal plasma cell proliferation disorder with various symptoms and signs caused by paraproteinemias. Among these signs, a bleeding tendency is one of the major fatal causes. However, significant severe bleeding is rare in most cases. In this study, we report a case of multiple myeloma in a patient who had a severe recurrent bleeding tendency due to platelet dysfunction caused by paraproteins. After being treated with therapeutic plasma exchange and chemotherapy, the patient’s monoclonal protein level decreased and the bleeding stopped. (Korean J Med 2012;83:823-827)

Abstract

Multiple myeloma is a monoclonal plasma cell proliferation disorder with various symptoms and signs caused by paraproteinemias. Among these signs, a bleeding tendency is one of the major fatal causes. However, significant severe bleeding is rare in most cases. In this study, we report a case of multiple myeloma in a patient who had a severe recurrent bleeding tendency due to platelet dysfunction caused by paraproteins. After being treated with therapeutic plasma exchange and chemotherapy, the patient’s monoclonal protein level decreased and the bleeding stopped. (Korean J Med 2012;83:823-827)

참고문헌 (13)

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  11. Czestochowska E, "Disturbances of platelet function in patients with multiple myeloma", Folia Haematol Int Mag Klin Morphol Blutforsch, 114, pp.845~851 (1987)
  12. 조영욱, "한국인 성인에서 Platelet Function Analyzer-100 폐색시간의분석 전 변수 확인 및 참고범위 설정", Annals of Laboratory Medicine, 27(5), pp.318~323 (2007), 대한진단검사의학회
  13. Siami GA, "Plasmapheresis and paraproteinemia: cryoprotein-induced diseases, monoclonal gammopathy, Waldenström's macroglobulinemia, hyperviscosity syndrome, multiple myeloma, light chain disease, and amyloidosis", Ther Apher, 3, pp.8~19 (1999)

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