Ginkgo biloba Administered Singly and Combined With Antioxidants in Tinnitus Patients
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Objectives: Tinnitus, or ear ringing, involves impulsive and spontaneous activity in the auditory neurons. Its prevalence is high in the elderly, but 10%–15% of adults suffer from tinnitus, affecting their quality of life. Therefore, this study aimed to evaluate the efficacy of <i>Ginkgo biloba</i> administered singly and in combination with antioxidants in tinnitus patients.Subjects and Methods: Patients were randomly allocated to Placebo (T0, n=22), Treatment 1 (T1, n=24), and Treatment 2 (T2, n=23) groups. The patients were educated on the study’s methodology and were instructed to visit at 0, 4, 8, 12, and 14 weeks. The placebo group received starch capsule supplements. Conversely, the treatment groups received <i>Ginkgo biloba</i> (60 mg twice a day) singly and in combination with antioxidants. We enrolled 69 patients aged 40–70 years (41 men, 28 women). The Tinnitus Handicap Index (THI), Visual Analogue Score (VAS), and Short Form 36 (SF-36) Health Scores were determined pre- and post-treatment at each visit.Results: Supplementation of <i>Ginkgo biloba</i>, along with antioxidants, provided marked improvement (<i>p</i><0.05) in post-treatment THI and VAS scores in the T2 group compared to those in the T1 and T0 groups. The greatest (<i>p</i><0.05) percent difference was observed in the pre- and post-treatment THI (-36%) and VAS scores (-22.6%) of T2 patients. Likewise, the SF-36 scores improved significantly (<i>p</i><0.05) in the T2 group in varied parameters.Conclusions: <i>Ginkgo biloba</i>, along with antioxidants, can be a promising therapy for tinnitus patients, providing marked improvement in THI, VAS, and SF-36 scores.
Abstract
Background and Objectives: Tinnitus, or ear ringing, involves impulsive and spontaneous activity in the auditory neurons. Its prevalence is high in the elderly, but 10%–15% of adults suffer from tinnitus, affecting their quality of life. Therefore, this study aimed to evaluate the efficacy of <i>Ginkgo biloba</i> administered singly and in combination with antioxidants in tinnitus patients.Subjects and Methods: Patients were randomly allocated to Placebo (T0, n=22), Treatment 1 (T1, n=24), and Treatment 2 (T2, n=23) groups. The patients were educated on the study’s methodology and were instructed to visit at 0, 4, 8, 12, and 14 weeks. The placebo group received starch capsule supplements. Conversely, the treatment groups received <i>Ginkgo biloba</i> (60 mg twice a day) singly and in combination with antioxidants. We enrolled 69 patients aged 40–70 years (41 men, 28 women). The Tinnitus Handicap Index (THI), Visual Analogue Score (VAS), and Short Form 36 (SF-36) Health Scores were determined pre- and post-treatment at each visit.Results: Supplementation of <i>Ginkgo biloba</i>, along with antioxidants, provided marked improvement (<i>p</i><0.05) in post-treatment THI and VAS scores in the T2 group compared to those in the T1 and T0 groups. The greatest (<i>p</i><0.05) percent difference was observed in the pre- and post-treatment THI (-36%) and VAS scores (-22.6%) of T2 patients. Likewise, the SF-36 scores improved significantly (<i>p</i><0.05) in the T2 group in varied parameters.Conclusions: <i>Ginkgo biloba</i>, along with antioxidants, can be a promising therapy for tinnitus patients, providing marked improvement in THI, VAS, and SF-36 scores.
참고문헌 (35)
- Bauer CA, "Tinnitus", N Engl J Med, 378, pp.1224~1231 (2018)
- Shargorodsky J, "Prevalence and characteristics of tinnitus among US adults", Am J Med, 123, pp.711~718 (2010)
- Baguley D, "Tinnitus", Lancet, 382, pp.1600~1607 (2013)
- McCormack A, "A systematic review of the reporting of tinnitus prevalence and severity", Hear Res, 337, pp.70~79 (2016)
- Hall DA, "A narrative synthesis of research evidence for tinnitus-related complaints as reported by patients and their significant others", Health Qual Life Outcomes, 16, pp.61~ (2018)
- Roberts LE, "Ringing ears : the neuroscience of tinnitus", J Neurosci, 30, pp.14972~14979 (2010)
- von Boetticher A, "Ginkgo biloba extract in the treatment of tinnitus : a systematic review", Neuropsychiatr Dis Treat, 7, pp.441~447 (2011)
- Mahmoudian-Sani MR, "Ginkgo biloba in the treatment of tinnitus : an updated literature review", Int Tinnitus J, 21, pp.58~62 (2017)
- Nguyen T, "Ginkgo biloba" (2022), StatPearls Publishing
- Rajarajan G, "A review on the medicinal properties of Gingko biloba", Drug Invent Today, 10, pp.3420~3423 (2018)
- 김태수, "The Effect of Korean Red Ginseng on Symptoms and Quality of Life in Chronic Tinnitus: A Randomized, Open-Label Pilot Study", Journal of Audiology & Otology, 19(2), pp.85~90 (2015), 대한청각학회
- Krauss P, "Therapeutic value of Ginkgo biloba extract EGb 761® in an animal model(Meriones unguiculatus)for noise trauma induced hearing loss and tinnitus", PLoS One, 11, pp.e0157574~ (2016)
- Henderson D, "The role of oxidative stress in noise-induced hearing loss", Ear Hear, 27, pp.1~19 (2006)
- Hall DA, "Treatment options for subjective tinnitus : self reports from a sample of general practitioners and ENT physicians within Europe and the USA", BMC Health Serv Res, 11, pp.302~ (2011)
- Chauhan B, "Role of antioxidants on the clinical outcome of patients with perennial allergic rhinitis", Allergy Rhinol(Providence), 7, pp.e74~81 (2016)
- Sereda M, "Ginkgo biloba for tinnitus", Cochrane Database of Systematic Reviews, 12, pp.CD013514~ (2019)
- Hasler A, "Complex flavonol glycosides from the leaves of Ginkgo biloba", Phytochemistry, 31, pp.1391~1394 (1992)
- Kleijnen J, "Ginkgo biloba", Lancet, 340, pp.1136~1139 (1992)
- Diamond BJ, "Ginkgo biloba : indications, mechanisms, and safety", Psychiatr Clin North Am, 36, pp.73~83 (2013)
- Omidkhoda SF, "Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation : a comprehensive review", Phytother Res, 33, pp.2821~2840 (2019)
- Blecharz-Klin K, "Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats", Acta Neurobiol Exp(Wars), 69, pp.217~231 (2009)
- Ude C, "Ginkgo biloba extracts : a review of the pharmacokinetics of the active ingredients", Clin Pharmacokinet, 52, pp.727~749 (2013)
- Diamond BJ, "Ginkgo biloba extract : mechanisms and clinical indications", Arch Phys Med Rehabil, 81, pp.668~678 (2000)
- Louajri A, "The effect of Ginkgo biloba extract on free radical production in hypoxic rats", Biol Pharm Bull, 24, pp.710~712 (2001)
- Cima RFF, "A multidisciplinary European guideline for tinnitus : diagnostics, assessment, and treatment", HNO, 67(Suppl 1), pp.10~42 (2019)
- McCombe A, "Guidelines for the grading of tinnitus severity : the results of a working group commissioned by the British Association of Otolaryngologists, Head and Neck Surgeons, 1999", Clin Otolaryngol Allied Sci, 26, pp.388~393 (2001)
- Zeman F, "Tinnitus handicap inventory for evaluating treatment effects : which changes are clinically relevant?", Otolaryngol Head Neck Surg, 145, pp.282~287 (2011)
- Figueiredo RR, "Correlation analysis of the visual-analogue scale and the Tinnitus Handicap Inventory in tinnitus patients", Braz J Otorhinolaryngol, 75, pp.76~79 (2009)
- Radunz CL, "Clinical randomized trial study of hearing aids effectiveness in association with Ginkgo biloba extract(EGb 761)on tinnitus improvement", Braz J Otorhinolaryngol, 86, pp.734~742 (2020)
- Raja KR, "Comparison of the efficacy between Ginkgo biloba and caroverine in the management of idiopathic tinnitus", Trop J Ophthalmol Otolaryngol, 6, pp.28~34 (2021)
- Procházková K, "Ginkgo biloba extract EGb 761® versus pentoxifylline in chronic tinnitus : a randomized, double-blind clinical trial", Int J Clin Pharm, 40, pp.1335~1341 (2018)
- Petridou AI, "The effect of antioxidant supplementation in patients with tinnitus and normal hearing or hearing loss : a randomized, double-blind, placebo controlled trial", Nutrients, 11, pp.3037~ (2019)
- Savastano M, "Antioxidant therapy in idiopathic tinnitus : preliminary outcomes", Arch Med Res, 38, pp.456~459 (2007)
- Schacht J, "Cisplatin and aminoglycoside antibiotics : hearing loss and its prevention", Anat Rec(Hoboken), 295, pp.1837~1850 (2012)
- Knäpper J, "Effectiveness of Tinnitan Duo® in subjective tinnitus with emotional affectation: a prospective, interventional study", J Diet Suppl, 20(1), pp.1~14 (2023)