Histologic and Micro-CT Findings by the Impact of Vitamin D on Osseointegration in the Ovariectomized Rat Maxilla: A Preliminary Study
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This study was aimed to determine the effect of vitamin D on bone formation around implant in the maxilla of osteoporotic rats. Fifteen female rats at 8 weeks-old were divided into three groups: 1) control group, sham-operated rats, 2) ovariectomized only group (OVX) and 3) ovariectomized and vitamin D-administered group (VitD). Eight weeks after the ovariectomy or sham operation, upper right molar was extracted, and an implant was placed at 4 weeks post-extraction. The vitamin D-administered experimental groups were given with 0.1 μg/kg/day via gavage while the OVX group and the control group received vehicle only. All rats in each group were sacrificed at 8 weeks and histologic and micro-computed tomographic (CT) evaluation were performed. According to the histologic observation, newly formed bone close to implant threads was mature with considerable quantity of bone marrow in the VitD group than the OVX group. In micro-CT findings, the VitD groups showed greater radiologic density of peri-implant bone close to implant threads than the OVX group. The results proposed that vitamin D could increase bone formation around implant. This might have clinical implications in dental implant treatment for patients with reduced bone formation capacity.
Abstract
This study was aimed to determine the effect of vitamin D on bone formation around implant in the maxilla of osteoporotic rats. Fifteen female rats at 8 weeks-old were divided into three groups: 1) control group, sham-operated rats, 2) ovariectomized only group (OVX) and 3) ovariectomized and vitamin D-administered group (VitD). Eight weeks after the ovariectomy or sham operation, upper right molar was extracted, and an implant was placed at 4 weeks post-extraction. The vitamin D-administered experimental groups were given with 0.1 μg/kg/day via gavage while the OVX group and the control group received vehicle only. All rats in each group were sacrificed at 8 weeks and histologic and micro-computed tomographic (CT) evaluation were performed. According to the histologic observation, newly formed bone close to implant threads was mature with considerable quantity of bone marrow in the VitD group than the OVX group. In micro-CT findings, the VitD groups showed greater radiologic density of peri-implant bone close to implant threads than the OVX group. The results proposed that vitamin D could increase bone formation around implant. This might have clinical implications in dental implant treatment for patients with reduced bone formation capacity.
참고문헌 (30)
- Dieter Busenlechner, "Long-term implant success at the Academy for Oral Implantology: 8-year follow-up and risk factor analysis", Journal of Periodontal & Implant Science, 44(3), pp.102~108 (2014), 대한치주과학회
- Pyo SW, "Bone formation on biomimetic calcium phosphate-coated and zoledronateimmobilized titanium implants in osteoporotic rat tibiae", Int J Oral Maxillofac Implants, 29, pp.478~484 (2014)
- Le Guehennec L, "Surface treatments of titanium dental implants for rapid osseointegration", Dent Mater, 23, pp.844~854 (2007)
- Alsaadi G, "Impact of local and systemic factors on the incidence of late oral implant loss", Clin Oral Implants Res, 19, pp.670~676 (2008)
- Bougas K, "Bone apposition to laminin-1 coated implants : histologic and 3D evaluation", Int J Oral Maxillofac Surg, 42, pp.677~682 (2013)
- Marco F, "Peri-implant osteogenesis in health and osteoporosis", Micron, 36, pp.630~644 (2005)
- Park S, "Intermittent Parathyroid Hormone Improves Bone Formation Around Titanium Implants in Osteoporotic Rat Maxillae", Int J Oral Maxillofac Implants, 32, pp.204~209 (2017)
- Apostu D, "Systemic drugs that influence titanium implant osseointegration", Drug Metab Rev, 49, pp.92~104 (2017)
- Mombelli A, "Systemic diseases affecting osseointegration therapy", Clin Oral Implants Res, 17(Suppl 2), pp.97~103 (2006)
- Rachner TD, "Osteoporosis : now and the future", Lancet, 377, pp.1276~1287 (2011)
- Kelly J, "Vitamin D and bone physiology : demonstration of vitamin D deficiency in an implant osseointegration rat model", J Prosthodont, 18, pp.473~478 (2009)
- 박현아, "비타민 D에 대한 최신지견", 대한의사협회지, 56(4), pp.310~318 (2013), 대한의사협회
- Erben RG, "Therapeutic efficacy of 1α,25-dihydroxyvitamin D3 and calcium in osteopenic ovariectomized rats: evidence for a direct anabolic effect of 1α,25-dihydroxyvitamin D3 on bone", Endocrinology, 139, pp.4319~4328 (1998)
- Choukroun J, "Two neglected biologic risk factors in bone grafting and implantology : high low-density lipoprotein cholesterol and low serum vitamin D", J Oral Implantol, 40, pp.110~114 (2014)
- Javed F, "Efficacy of Vitamin D3 Supplementation on Osseointegration of Implants", Implant Dent, 25, pp.281~287 (2016)
- Hong HH, "The potential effects of cholecalciferol on bone regeneration in dogs", Clin Oral Implants Res, 23, pp.1187~1192 (2012)
- Hong HH, "Association of vitamin D3 with alveolar bone regeneration in dogs", J Cell Mol Med, 19, pp.1208~1217 (2015)
- Dvorak G, "Impact of dietary vitamin D on osseointegration in the ovariectomized rat", Clin Oral Implants Res, 23, pp.1308~1313 (2012)
- Zhou C, "1,25Dihydroxy vitamin D(3) improves titanium implant osseointegration in osteoporotic rats", Oral Surg Oral Med Oral Pathol Oral Radiol., 114, pp.S174~S178 (2012)
- Naito Y, "The influence of 1α.25-dihydroxyvitamin d3 coating on implant osseointegration in the rabbit tibia", J Oral Maxillofac Res, 5, pp.e3~ (2014)
- Bischoff-Ferrari HA, "Positive association between 25-hydroxy vitamin D levels and bone mineral density : a population-based study of younger and older adults", Am J Med, 116, pp.634~639 (2004)
- Cho YJ, "Promotion of osseointegration of anodized titanium implants with a 1α,25-dihydroxyvitamin D3 submicron particle coating", Int J Oral Maxillofac Implants, 26, pp.1225~1232 (2011)
- Mangano F, "Is Low Serum Vitamin D Associated with Early Dental Implant Failure? A Retrospective Evaluation on 1625 Implants Placed in 822Patients", Mediators Inflamm, 2016, pp.5319718~ (2016)
- Hearing YN, "The Influence of 1α.25-Dihydroxyvitamin D3 Coating on Implant Osseointegration in the Rabbit Tibia", J Oral Maxillofac Res, 5, pp.e3~ (2014)
- Kuchuk NO, "Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons", J Clin Endocrinol Metab, 94, pp.1244~1250 (2009)
- Liu H, "Local administration of calcitriol positively influences bone remodeling and maturation during restoration of mandibular bone defects in rats", Mater Sci Eng C Mater Biol Appl, 49, pp.14~24 (2015)
- Salomo-Coll O, "Topical applications of vitamin D on implant surface for boneto-implant contact enhance : a pilot study in dogs part II", Clin Oral Implants Res, 27, pp.896~903 (2016)
- Schulze-Spate U, "Systemic vitamin D supplementation and local bone formation after maxillary sinus augmentation - a randomized, double-blind, placebo-controlled clinical investigation", Clin Oral Implants Res, 27, pp.701~706 (2016)
- Vandeweghe S, "Utilizing micro-computed tomography to evaluate bone structure surrounding dental implants : A comparison with histomorphometry", J Biomed Mater Res B Appl Biomater, 101, pp.1259~1266 (2013)
- Tang X, "Osteogenic induction and 1,25-dihydroxyvitamin D3 oppositely regulate the proliferation and expression of RANKL and the vitamin D receptor of human periodontal ligament cells", Arch Oral Biol, 54, pp.625~633 (2009)