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성인 여성에서 납의 체내 노출 수준과 심혈관질환과의 융복합 연구 : 제7기 국민건강영양조사 자료 이용 (2017)

A convergence study on the exposure levels of lead and cardiovascular diseases in adults women using the 7th Korea National Health and Nutrition Examination Survey (2017)

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키워드

주제분류학제간연구

초록

본 연구는 한국 성인 여성의 체내 납 (Pb) 노출 수준과 심혈관질환 (CVD) 사이의 관계를 분석하기 위해 수행되었다. 2017년 국민건강영양조사 (KNHANES)에 참여한 만 19세 이상 성인 1,821명을 대상으로 혈중 납과 허혈성 심장 질환 (IHD), 뇌졸중 및 고혈압의 자가 보고한 의사 진단에 대한 단면 자료를 이용하였다. CVD 및 혈중 납 농도는 로지스틱 회귀분석을 통해 분석하였고, pearson 상관계수를 이용하여 요인 간의 상관관계를 확인하였다. 혈중 납 수치 증가는 여성에서만 허혈성 심장 질환 (OR 5.68, 95% CI 1.01-17.51) 및 고혈압 (OR 3.37, 95% CI 2.24-5.07) 위험 증가와 연관이 있었다. 또한, 혈중 납과 영양소 섭취 사이에는 상관관계가 있었다. 이는 혈중 납 수치가 CVD 발병의 주요 예측 인자로 사용될 수 있으며 여성이 납 노출과 관련된 IHD 및 고혈압에 더 취약하다는 것을 시사한다.

Abstract

This study was conducted to analyze the relationship between the levels of lead (Pb) exposure and cardiovascular disease (CVD) in Korean adult women. We used cross-sectional data on blood lead and self-reported diagnoses of ischemic heart disease (IHD), stroke and hypertension in a subsample of 1.821 adults 19 years and older who participated in the 2017 Korea National Health and Nutrition Examination Survey (KNHANES). CVD and blood Pb concentrations were analyzed through logistic regression analysis, and correlations between factors were confirmed using the pearson correlation coefficient. An increase of blood Pb was associated with an increased risk of IHD (OR 5.68, 95% CI 1.01-17.51) and hypertension (OR 3.37, 95% CI 2.24-5.07) only in women. Additionally, there was a correlation between blood Pb and nutrient intake. This suggest that blood Pb levels may be used as a key predictor of CVD development, and that women are more susceptable to IHD and hypertension associated with Pb exposure.

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