Health Risk Impact from 131I Exposure to Low or High Doses Evaluated with Micronucleus Assay
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Despite the fact that the precautions to be taken are clearly established, accidentalexposures from various radiation sources, including nuclear power plants, in which emerge of the131I among emission of various radioactive isotopes, might be one of the first sign of misfortune,that even if infrequently, continue to occur. In human body, iodine, is preferentially concentratingin the thyroid, though, it is frequently used in nuclear medicine both diagnostically and therapeutically. The aim of our study was to investigate the influence of radioiodine-131, from the diagnosticand therapeutic treatment exposures, on cellular DNA repair efficiency and various biomarkersof effects, in order to estimate a potentially associated health risk at low and high dose regions. Study group consisted of 41 individuals diagnostically exposed to low dose of the 131I (in the range1.85~4.45 MBq, A´sr=2.96±0.82 MBq) and 37 persons therapeutically exposed to high dose ofthe 131I (in the range 300~650 MBq, A´sr=497.3±88.1 MBq). A reference group consisted of 30healthy individuals. Blood samples that were collected for the investigations underwent immediatelycytogenetic procedures according to standard protocols for retrospective biological dosimetry. Strong variation between cellular responses of thyroid diseases patients to both low and highdoses of 131I is observed, although, mean value of cytogenetic damage is in the group investigatedafter diagnostic treatment lower than in control. Nevertheless, five weeks after the therapeuticdose of 131I, in majority of patients significantly elevated levels of cytogenetic damage are observed,that suggest a possible increase of secondary cancer risk. Suppression of detected level ofcytogenetic damage observed for some individuals in a high dose region might suggest limitationof this biomarker for retrospective biological dosimetry in the wide range of doses or necessity ofinvestigation of personalised susceptibility.
Abstract
Despite the fact that the precautions to be taken are clearly established, accidentalexposures from various radiation sources, including nuclear power plants, in which emerge of the131I among emission of various radioactive isotopes, might be one of the first sign of misfortune,that even if infrequently, continue to occur. In human body, iodine, is preferentially concentratingin the thyroid, though, it is frequently used in nuclear medicine both diagnostically and therapeutically. The aim of our study was to investigate the influence of radioiodine-131, from the diagnosticand therapeutic treatment exposures, on cellular DNA repair efficiency and various biomarkersof effects, in order to estimate a potentially associated health risk at low and high dose regions. Study group consisted of 41 individuals diagnostically exposed to low dose of the 131I (in the range1.85~4.45 MBq, A´sr=2.96±0.82 MBq) and 37 persons therapeutically exposed to high dose ofthe 131I (in the range 300~650 MBq, A´sr=497.3±88.1 MBq). A reference group consisted of 30healthy individuals. Blood samples that were collected for the investigations underwent immediatelycytogenetic procedures according to standard protocols for retrospective biological dosimetry. Strong variation between cellular responses of thyroid diseases patients to both low and highdoses of 131I is observed, although, mean value of cytogenetic damage is in the group investigatedafter diagnostic treatment lower than in control. Nevertheless, five weeks after the therapeuticdose of 131I, in majority of patients significantly elevated levels of cytogenetic damage are observed,that suggest a possible increase of secondary cancer risk. Suppression of detected level ofcytogenetic damage observed for some individuals in a high dose region might suggest limitationof this biomarker for retrospective biological dosimetry in the wide range of doses or necessity ofinvestigation of personalised susceptibility.
참고문헌 (5)
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