임상적으로 간과하기 쉬운 부갑상선암에 의한 부갑상선기능항진증 1예
A Case of Parathyroid Carcinoma Presenting Hyperparathyroidism that was Clinically Easy to Overlook
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
부갑상선암은 원발성 부갑상선기능항진증 원인의 약 1~2%로, 국내에서 증례 보고가 매우 드물다. 부갑상선암에 의해 발생한 부갑상선 기능항진증은 선종에 비하여 고칼슘혈증이 심하며, 신질환이 동반되는 경우가 흔하다. 부갑상선암의 경우일반적인 일차성 부갑상선기능항진증에 비하여 더 높은 혈중 칼슘 수치, 신기능이상, 뼈 대사의 이상 소견이 많이 나타나는 것으로 알려져 있다. 저자들은 6년 동안의 고칼슘혈증이 있었으나 특이한 임상 증상이 없어 진단하기 어려웠던 부갑상선암에 의한 부갑상선기능항진증을 진단하고 치료한 1예를 경험하여 보고하는 바이다.
Abstract
Parathyroid carcinoma is very rare in patients with primary hyperparathyroidism, only accounts for 1% to 2% of all cases. It is characterized by higher incidence of renal dysfunction, metabolic bone disease and gastrointestinal symptoms. Although the clinical manifestations of hyperparathyroidism are more severe in patients with parathyroid carcinoma when compared to those with those with parathyroid adenoma, it is difficult to differentiate carcinoma from adenoma without pathologic confirmation. To our knowledge, there have only been a few cases of hyperparathyroidism due to parathyroid carcinomas reported to date. Here, we report a case of 63-year-old woman developing osteoporosis,hypercalcemia and hypophosphatemia due to a parathyroid tumor and was diagnosed with parathyroid carcinoma postoperatively.
참고문헌 (15)
- Mittendorf EA, "Parathyroid carcinoma", J Surg Oncol, 89, pp.136~142 (2005)
- Busaidy NL, "Parathyroid carcinoma: a 22-year experience", Head Neck, 26, pp.716~726 (2004)
- Shane E, "Clinical review 122: Parathyroid carcinoma", J Clin Endocrinol Metab, 86, pp.485~493 (2001)
- Bates D, "American College of Endocrinology and American Association of Clinical Endocrinologists position statement on patient safety and medical system errors in diabetes and endocrinology", Endocr Pract, 11, pp.197~202 (2005)
- DeLellis RA, "Parathyroid carcinoma: an overview", Adv Anat Pathol, 12, pp.53~61 (2005)
- Mazzaglia PJ, "The changing presentation of hyperparathyroidism over 3 decades", Arch Surg, 143, pp.260~266 (2008)
- Potts JT, "Diseases of the parathyroid gland and other hyperand hypocalcemic disorders, In Harrison's principles of internal medicine. 17th ed" (2008), Mc Graw-Hill
- 김정구, "부갑상선암", 대한외과학회지, 62(2), pp.173~177 (2002), 대한외과학회
- Levin KE, "Parathyroid carcinoma versus parathyroid adenoma in patients with profound hypercalcemia", Surgery, 101, pp.649~660 (1987)
- Edelson GW, "Hypercalcemic crisis", Med Clin North Am, 79, pp.79~92 (1995)
- Ariyan CE, "Assessment and management of patients with abnormal calcium", Crit Care Med, 32, pp.S146~S154 (2004)
- Clark OH, "Localization studies in patients with persistent or recurrent hyperparathyroidism", Surgery, 98, pp.1083~1094 (1985)
- Stark DD, "Parathyroid imaging: comparison of high-resolution CT and high-resolution sonography", AJR Am J Roentgenol, 141, pp.633~638 (1983)
- Koea JB, "Parathyroid cancer: biology and management", Surg Oncol, 8, pp.155~165 (1999)
- Hundahl SA, "Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society", Cancer, 86, pp.538~544 (1999)