A Case of Cushing Syndrome Diagnosed by Recurrent Pathologic Fractures in a Young Woman
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Cushing's syndrome is characterized by central obesity, fatigability, weakness, amenorrhea, hirsutism, edema,hypertension, impaired glucose tolerance, and osteoporosis due to excessive production of steroids. Cushing's syndrome is an important cause of secondary osteoporosis. Patients with Cushing's syndrome have a high incidence of osteoporotic fractures. At least, 30-50% of patients with Cushing's syndrome experience fractures, particularly in the vertebral body. And it is consistent with the 50% prevalence of osteoporosis in patients with Cushing's syndrome. However,reports of multiple pathological fractures in young patients with Cushing's syndrome are rare. Thus, we describe the case of a 26-year-old woman with Cushing's syndrome accompanied with recurrent multiple osteoporotic fractures and being treated by parathyroid hormone. Careful consideration for the possibility of Cushing's syndrome will be necessary in case of young patients with a spontaneous multiple compression fractures in spine.
Abstract
Cushing's syndrome is characterized by central obesity, fatigability, weakness, amenorrhea, hirsutism, edema,hypertension, impaired glucose tolerance, and osteoporosis due to excessive production of steroids. Cushing's syndrome is an important cause of secondary osteoporosis. Patients with Cushing's syndrome have a high incidence of osteoporotic fractures. At least, 30-50% of patients with Cushing's syndrome experience fractures, particularly in the vertebral body. And it is consistent with the 50% prevalence of osteoporosis in patients with Cushing's syndrome. However,reports of multiple pathological fractures in young patients with Cushing's syndrome are rare. Thus, we describe the case of a 26-year-old woman with Cushing's syndrome accompanied with recurrent multiple osteoporotic fractures and being treated by parathyroid hormone. Careful consideration for the possibility of Cushing's syndrome will be necessary in case of young patients with a spontaneous multiple compression fractures in spine.
참고문헌 (12)
- 정민형, "부신 선종에 의한 쿠싱증후군에 동반된 척추압박골절", OSTEOPOROSIS, 7(3), pp.209~213 (2009), 대한골다공증학회
- Arnaldi G, "Diagnosis and complications of Cushing's syndrome: a consensus statement", J Clin Endocrinol Metab, 88, pp.5593~5602 (2003)
- Mancini T, "Cushing's syndrome and bone", Pituitary, 7, pp.249~252 (2004)
- Ohmori N, "Osteoporosis is more prevalent in adrenal than in pituitary Cushing's syndrome", Endocr J, 50, pp.1~7 (2003)
- Pereira RM, "Guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis", Rev Bras Reumatol, 52, pp.580~593 (2012)
- Canalis E, "Perspectives on glucocorticoid-induced osteoporosis", Bone, 34, pp.593~598 (2004)
- Mazziotti G, "Glucocorticoidinduced osteoporosis: an update", Trends Endocrinol Metab, 17, pp.144~149 (2006)
- Faggiano A, "Spine abnormalities and damage in patients cured from Cushing's disease", Pituitary, 4, pp.153~161 (2001)
- Manning PJ, "Normal bone mineral density following cure of Cushing's syndrome", Clin Endocrinol (Oxf), 36, pp.229~234 (1992)
- Di Somma C, "Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease", Clin Endocrinol (Oxf), 48, pp.655~662 (1998)
- Rehman Q, "Daily treatment with parathyroid hormone is associated with an increase in vertebral cross-sectional area in postmenopausal women with glucocorticoid-induced osteoporosis", Osteoporos Int, 14, pp.77~81 (2003)
- Saag KG, "Teriparatide or alendronate in glucocorticoid-induced osteoporosis", N Engl J Med, 357, pp.2028~2039 (2007)