Prevalence of Osteoporosis in Korean Patients with Chronic Obstructive Pulmonary Disease and Their Health-related Quality of Life According to the Korea National Health and Nutrition Examination Survey 2008-2011
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Background: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. Methods: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed. Results: Of the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, patients of male sex (odds ratio [OR]=0.06, P<0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P<0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=-0.21, P=0.023). Conclusions: The prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.
Abstract
Background: In this study, we evaluated the prevalence of osteoporosis, risk factors associated with osteoporosis, and health-related quality of life (HRQOL) in clinically stable chronic obstructive pulmonary disease (COPD) patients. Methods: A total of 1,081 COPD patients were recruited from the Korea National Health and Nutrition Examination Survey (KNHANES) from July 2008 to May 2011. Bone mineral densities at the lumbar spine, femoral neck, and total proximal femur were measured using dual energy X-ray absorptiometry. HRQOL was assessed using the EuroQOL-5 dimensions (EQ-5D) questionnaire. To identify factors associated with osteoporosis and HRQOL in patients with COPD, multivariate regression analyses was performed. Results: Of the 1,081 COPD patients, 191 (17.7%) were diagnosed with osteoporosis. There were significant differences in age, sex, smoking status, education level, house income, and body mass index (BMI) between the osteoporotic and non-osteoporotic groups. COPD patients with osteoporosis had significantly lower EQ-5D scores than the controls. In multivariate analyses, patients of male sex (odds ratio [OR]=0.06, P<0.001), high house income (OR=0.75, P=0.045), and high BMI (OR=0.74, P<0.001) were less likely to have osteoporosis. In addition, osteoporosis was associated with poor HRQOL (β=-0.21, P=0.023). Conclusions: The prevalence of osteoporosis in COPD patients based on the 2008 to 2011 KNHANES data were relatively lower than that in physician-diagnosed COPD patients. In these COPD patients, older age, female sex, low household income, and low BMI increased the risk for osteoporosis.
참고문헌 (34)
- Lehouck A, "COPD, bone metabolism, and osteoporosis", Chest, 139, pp.648~657 (2011)
- "NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy", JAMA, 285, pp.785~795 (2001)
- Haentjens P, "Meta-analysis: excess mortality after hip fracture among older women and men", Ann Intern Med, 152, pp.380~390 (2010)
- Inoue D, "COPD and osteoporosis: links, risks, and treatment challenges", Int J Chron Obstruct Pulmon Dis, 11, pp.637~648 (2016)
- Bolton CE, "Associated loss of fat-free mass and bone mineral density in chronic obstructive pulmonary disease", Am J Respir Crit Care Med, 170, pp.1286~1293 (2004)
- Ferguson GT, "Prevalence and progression of osteoporosis in patients with COPD:results from the TOwards a Revolution in COPD Health study", Chest, 136, pp.1456~1465 (2009)
- Sin DD, "The risk of osteoporosis in Caucasian men and women with obstructive airways disease", Am J Med, 114, pp.10~14 (2003)
- Putcha N, "Comorbidities and chronic obstructive pulmonary disease: prevalence, influence on outcomes, and management", Semin Respir Crit Care Med, 36, pp.575~591 (2015)
- Wen CP, "Smoking behaviour in Taiwan, 2001", Tob Control, 14(Suppl 1), pp.i51~i55 (2005)
- Korea health statistics 2010-2012: Korea national health and nutrition examination survey (KNHANES V) 2010-2012, "Ministry of Health & Welfare", Ministry of Health & Welfare, ~ (2012)
- "The global strategy for the diagnosis, management and prevention of COPD" (2017)[URL]
- Miller MR, "Standardisation of spirometry", Eur Respir J, 26, pp.319~338 (2005)
- World Health Organization, "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis", World Health Organ Tech Rep Ser, 843, pp.1~129 (1994)
- Pickard AS, "Use of a preference-based measure of health (EQ-5D) in COPD and asthma", Respir Med, 102, pp.519~536 (2008)
- Lee YK, "South Korean time trade-off values for EQ-5D health states: modeling with observed values for 101 health states", Value Health, 12, pp.1187~1193 (2009)
- Franco CB, "Chronic obstructive pulmonary disease is associated with osteoporosis and low levels of vitamin D", Osteoporos Int, 20, pp.1881~1887 (2009)
- Jeon YK, "The relationship between pulmonary function and bone mineral density in healthy nonsmoking women: the Korean National Health and Nutrition Examination Survey (KNHANES) 2010", Osteoporos Int, 25, pp.1571~1576 (2014)
- 박은정, "Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011", Yonsei Medical Journal, 55(4), pp.1049~1057 (2014), 연세대학교의과대학[DOI]
- Watanabe R, "Osteoporosis is highly prevalent in Japanese males with chronic obstructive pulmonary disease and is associated with deteriorated pulmonary function", J Bone Miner Metab, 33, pp.392~400 (2015)
- Vrieze A, "Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass", Osteoporos Int, 18, pp.1197~1202 (2007)
- Kjensli A, "High prevalence of vertebral deformities in COPD patients: relationship to disease severity", Eur Respir J, 33, pp.1018~1024 (2009)
- Gan WQ, "Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis", Thorax, 59, pp.574~580 (2004)
- Pitta F, "Characteristics of physical activities in daily life in chronic obstructive pulmonary disease", Am J Respir Crit Care Med, 171, pp.972~977 (2005)
- Lee JH, "Amount of smoking, pulmonary function, and bone mineral density in middle-aged Korean men: KNHANES 2008-2011", J Bone Miner Metab (2017)[DOI]
- Vestbo J, "Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample: findings from the Copenhagen City Heart Study", Am J Respir Crit Care Med, 173, pp.79~83 (2006)
- Graat-Verboom L, "Correlates of osteoporosis in chronic obstructive pulmonary disease: an underestimated systemic component", Respir Med, 103, pp.1143~1151 (2009)
- Reid IR, "Relationships between fat and bone", Osteoporos Int, 19, pp.595~606 (2008)
- Remels AH, "The mechanisms of cachexia underlying muscle dysfunction in COPD", J Appl Physiol, 114, pp.1253~1262 (2013)
- Menn P, "Health-related quality of life in patients with severe COPD hospitalized for exacerbations - comparing EQ-5D, SF-12 and SGRQ", Health Qual Life Outcomes, 8, pp.39~ (2010)
- Rutten-van Mölken MP, "Does quality of life of COPD patients as measured by the generic EuroQol five-dimension questionnaire differentiate between COPD severity stages?", Chest, 130, pp.1117~1128 (2006)
- 권혜영, "Health-related Quality of Life in Accordance with Fracture History and Comorbidities in Korean Patients with Osteoporosis", 대한골대사학회지, 23(4), pp.199~206 (2016), 대한골대사학회[DOI]
- 정호진, "Quality of Life in Patients with Osteoporotic Vertebral Compression Fractures", 대한골대사학회지, 24(3), pp.187~196 (2017), 대한골대사학회[DOI]
- Sundh J, "Comorbidity and health-related quality of life in patients with severe chronic obstructive pulmonary disease attending Swedish secondary care units", Int J Chron Obstruct Pulmon Dis, 10, pp.173~183 (2015)
- Papaioannou A, "Prevalence of vertebral fractures among patients with chronic obstructive pulmonary disease in Canada", Osteoporos Int, 14, pp.913~917 (2003)