본문 바로가기
KERD
논문KCI 등재

Effect of Romosozumab on Trabecular Bone Score Compared to Anti-Resorptive Agents in Postmenopausal Women with Osteoporosis

김진영|임예지|하정훈|백기현|정채호|강무일
대한골대사학회 (The Korean Society of Bone Metabolism)|2021.11|대한골대사학회지 (Journal of Bone Metabolism)|제28권 제4호|pp. 317-323

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

PostmenopauseOsteoporosisBone densityCancellous boneRomosozumab
주제분류정형외과학

초록

Background: Romosozumab has shown significant improvement in bone mineral density (BMD) in previously reported trials. However, BMD reflects only bone strength and does not offer insight into the bone microarchitecture. The trabecular bone score (TBS) is a non-invasive tool used to assess bone microarchitecture. Several previous studies have evaluated the efficacy of anti-osteoporotic agents using the TBS. However, data regarding the potency of romosozumab based on the TBS is lacking. This retrospective observational cohort study demonstrated the impact of romosozumab use on the TBS. Methods: The primary outcome was the percentage change in the TBS from baseline to post-treatment. Postmenopausal osteoporosis patients were followed up for 6 and 12 months after romosozumab (210 mg monthly, N =10) and denosumab (60 mg every 6 months, N=21) or ibandronate (150 mg monthly, N=24) treatments, respectively. Patients who had previously used osteoporosis medications were included, if any the washout period was sufficient. Results: The percentage change in TBS from baseline to post-treatment was 2.53±2.98% (6 months, N=10; P=0.04), 0.59%±3.26% (12 months, N=21; P=0.48), and -0.45±3.66% (12 months, N=24; P=0.51) in the romosozumab, denosumab, and ibandronate groups, respectively. Romosozumab demonstrated a noticeable increase in TBS, although it did not reach the least significant change (5.8%) in TBS. Conclusions: Romosozumab improved the TBS in postmenopausal women with osteoporosis. TBS may be potentially useful for monitoring romosozumab treatment.

Abstract

Background: Romosozumab has shown significant improvement in bone mineral density (BMD) in previously reported trials. However, BMD reflects only bone strength and does not offer insight into the bone microarchitecture. The trabecular bone score (TBS) is a non-invasive tool used to assess bone microarchitecture. Several previous studies have evaluated the efficacy of anti-osteoporotic agents using the TBS. However, data regarding the potency of romosozumab based on the TBS is lacking. This retrospective observational cohort study demonstrated the impact of romosozumab use on the TBS. Methods: The primary outcome was the percentage change in the TBS from baseline to post-treatment. Postmenopausal osteoporosis patients were followed up for 6 and 12 months after romosozumab (210 mg monthly, N =10) and denosumab (60 mg every 6 months, N=21) or ibandronate (150 mg monthly, N=24) treatments, respectively. Patients who had previously used osteoporosis medications were included, if any the washout period was sufficient. Results: The percentage change in TBS from baseline to post-treatment was 2.53±2.98% (6 months, N=10; P=0.04), 0.59%±3.26% (12 months, N=21; P=0.48), and -0.45±3.66% (12 months, N=24; P=0.51) in the romosozumab, denosumab, and ibandronate groups, respectively. Romosozumab demonstrated a noticeable increase in TBS, although it did not reach the least significant change (5.8%) in TBS. Conclusions: Romosozumab improved the TBS in postmenopausal women with osteoporosis. TBS may be potentially useful for monitoring romosozumab treatment.

참고문헌 (33)

  1. T.P van Staa, "Epidemiology of fractures in England and Wales", Bone, 29(6), pp.517~522 (2001), Elsevier BV[DOI]
  2. Felicia Cosman, "Romosozumab treatment in postmenopausal women with osteoporosis", New England Journal of Medicine, 375(16), pp.1532~1543 (2016), Massachusetts Medical Society[DOI]
  3. Michael R. McClung, "Romosozumab in Postmenopausal Women with Low Bone Mineral Density", New England Journal of Medicine, 370(5), pp.412~420 (2014), Massachusetts Medical Society[DOI]
  4. Xiaofeng Li, "Sclerostin Binds to LRP5", 6 and Antagonizes Canonical Wnt Signaling, 2005, pp.280(20), 19883~19887[DOI]
  5. Kenneth G. Saag, "Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis", New England Journal of Medicine, 377(15), pp.1417~1427 (2017), Massachusetts Medical Society[DOI]
  6. Luca Dalle Carbonare, "Bone microarchitecture as an important determinant of bone strength", Journal of Endocrinological Investigation, 27(1), pp.99~105 (2004), Springer Science and Business Media LLC[DOI]
  7. Majumdar S, "A review of magnetic resonance(MR)imaging of trabecular bone micro-architecture : contribution to the prediction of biomechanical properties and fracture prevalence", Technol Health Care, 6, pp.321~327 (1998)
  8. 공성혜, "Application of the Trabecular Bone Score in Clinical Practice", 대한골대사학회지, 28(2), pp.101~113 (2021), 대한골대사학회
  9. Barbara C Silva, "Trabecular Bone Score: A Noninvasive Analytical Method Based Upon the DXA Image", Journal of Bone and Mineral Research, 29(3), pp.518~530 (2014), Wiley[DOI]
  10. J. Ramalho, "The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients with chronic kidney disease", Bone, 116, pp.215~220 (2018), Elsevier BV[DOI]
  11. Barbara C. Silva, "Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score", Journal of Clinical Densitometry, 18(3), pp.309~330 (2015), Elsevier BV[DOI]
  12. Kelly Krohn, "Dual-energy X-ray Absorptiometry Monitoring with Trabecular Bone Score: 2019 ISCD Official Position", Journal of Clinical Densitometry, 22(4), pp.501~505 (2019), Elsevier BV[DOI]
  13. E. Leib, "Comparing Bone Microarchitecture by Trabecular Bone Score (TBS) in Caucasian American Women with and Without Osteoporotic Fractures", Calcified Tissue International, 95(3), pp.201~208 (2014), Springer Science and Business Media LLC[DOI]
  14. J. Touvier, "Fracture Discrimination by Combined Bone Mineral Density (BMD) and Microarchitectural Texture Analysis", Calcified Tissue International, 96(4), pp.274~283 (2015), Springer Science and Business Media LLC[DOI]
  15. Bénédicte Rabier, "A multicentre, retrospective case-control study assessing the role of trabecular bone score (TBS) in menopausal Caucasian women with low areal bone mineral density (BMDa): Analysing the odds of vertebral fracture", Bone, 46(1), pp.176~181 (2010), Elsevier BV[DOI]
  16. Renaud Winzenrieth, "A retrospective case-control study assessing the role of trabecular bone score in postmenopausal Caucasian women with osteopenia: analyzing the odds of vertebral fracture", Calcified Tissue International, 86(2), pp.104~109 (2010), Springer Science and Business Media LLC[DOI]
  17. L. M. Del Rio, "Is bone microarchitecture status of the lumbar spine assessed by TBS related to femoral neck fracture? A Spanish case-control study", Osteoporosis International, 24(3), pp.991~998 (2013), Springer Science and Business Media LLC[DOI]
  18. K. Nassar, "Added value of trabecular bone score over bone mineral density for identification of vertebral fractures in patients with areal bone mineral density in the non-osteoporotic range", Osteoporosis International, 25(1), pp.243~249 (2014), Springer Science and Business Media LLC[DOI]
  19. Didier Hans, "Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study", Journal of Bone and Mineral Research, 26(11), pp.2762~2769 (2011), Wiley[DOI]
  20. S. Boutroy, "Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study", Osteoporosis International, 24(1), pp.77~85 (2013), Springer Science and Business Media LLC[DOI]
  21. Eugene V McCloskey, "A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX", Journal of Bone and Mineral Research, 31(5), pp.940~948 (2016), Wiley[DOI]
  22. Albrecht W Popp, "Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: a three-year study", Journal of Bone and Mineral Research, 28(3), pp.449~454 (2013), Wiley[DOI]
  23. C. Senn, "Comparative effects of teriparatide and ibandronate on spine bone mineral density (BMD) and microarchitecture (TBS) in postmenopausal women with osteoporosis: a 2-year open-label study", Osteoporosis International, 25(7), pp.1945~1951 (2014), Springer Science and Business Media LLC[DOI]
  24. M. R. McClung, "Effect of denosumab on trabecular bone score in postmenopausal women with osteoporosis", Osteoporosis International, 28(10), pp.2967~2973 (2017), Springer Science and Business Media LLC[DOI]
  25. R. Rizzoli, "Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study", Osteoporosis International, 23(1), pp.305~315 (2012), Springer Science and Business Media LLC[DOI]
  26. Ego Seeman, "Bone Quality — The Material and Structural Basis of Bone Strength and Fragility", New England Journal of Medicine, 354(21), pp.2250~2261 (2006), Massachusetts Medical Society[DOI]
  27. J. P. Bilezikian, "Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial", Osteoporosis International, 29(2), pp.323~328 (2018), Springer Science and Business Media LLC[DOI]
  28. Kenneth G. Saag, "Trabecular bone score in patients with chronic glucocorticoid therapy-induced osteoporosis treated with alendronate or teriparatide", Arthritis & Rheumatology, 68(9), pp.2122~2128 (2016), Wiley[DOI]
  29. Pascale Chavassieux, "Bone-forming and antiresorptive effects of romosozumab in postmenopausal women with osteoporosis: Bone histomorphometry and microcomputed tomography analysis after 2 and 12 months of treatment", Journal of Bone and Mineral Research, 34(9), pp.1597~1608 (2019), Wiley[DOI]
  30. Monique Arlot, "Differential effects of teriparatide and alendronate on bone remodeling in postmenopausal women assessed by histomorphometric parameters", Journal of Bone and Mineral Research, 20(7), pp.1244~1253 (2005), Wiley[DOI]
  31. Carolina A. Moreira, "Effects of abaloparatide-SC (BA058) on bone histology and histomorphometry: The ACTIVE phase 3 trial", Bone, 97, pp.314~319 (2017), Elsevier BV[DOI]
  32. Laurent Pothuaud, "Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture", Bone, 42(4), pp.775~787 (2008), Elsevier BV[DOI]
  33. Didier Hans, "Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: an experimental study on human cadaver vertebrae", Journal of Clinical Densitometry, 14(3), pp.302~312 (2011), Elsevier BV[DOI]

관련 논문AI추천

Erratum : Effect of Romosozumab on Trabecular Bone Score Compared to Anti-Resorptive Agents in Postmenopausal Women with Osteoporosis김진영, 임예지, 정채호, Jeonghoon Ha, Ki-Hyun Baek, Moo-Il Kang대한골대사학회 · 대한골대사학회지2022 · 제29권 제4호Longitudinal Change in Trabecular Bone Score during and after Treatment of Osteoporosis in Postmenopausal Korean Women김하영, 신미선, 조은희대한골대사학회 · 대한골대사학회지2017 · 제24권 제2호Efficacy and Cardiovascular Safety of Romosozumab: A Meta-analysis and Systematic Review김정민, 오상현, 정지은, 천승현, 최서용한국임상약학회 · 한국임상약학회지2023 · 제33권 제2호Two-Year Outcomes of Daily and Twice-Weekly Teriparatide Treatment in Postmenopausal Women with Severe Osteoporosis: A Randomized Non-Blinded Prospective StudyKatsunori Ikari, Ken Okazaki, Koichiro Yano, Takeshi Mochizuki대한골대사학회 · 대한골대사학회지2024 · 제31권 제2호The Effect of Denosumab on Bone Mass in Super Elderly Patients하정훈, Chaiho Jeong대한골대사학회 · 대한골대사학회지2020 · 제27권 제2호Predictive Factors for Increased Bone Density Following Romosozumab Administration Based on Pre-Administration Blood Test ResultsAkira Kuwabara, Kazuhide Inage, Kohei Okuyama, Masahiro Inoue, Masaomi Yamashita, Miyako Suzuki-Narita, Noritaka Suzuki, Noriyasu Toshi, Seiji Ohtori, Shuhei Ohyama, Soichiro Tokeshi, Sumihisa Orita, Susumu Tashiro, Takahisa Hishiya, Takahito Arai, Yasuhiro Shiga, Yawara Eguchi연세대학교의과대학 · Yonsei Medical Journal2025 · 제66권 제4호

이 간행물의 다른 논문 (9건)

Discordance between Hip and Spine Bone Mineral Density: A Point of Care윤병호, 김덕윤pp. 249-251Effects of Different Types of Mechanical Loading on Trabecular Bone Microarchitecture in RatsYong-In Ju, Teruki Sonepp. 253-265The Potential Role of Exercise Training and Mechanical Loading on Bone-Associated Skeletal NervesSeungyong Lee, T. Jake Samuel, Stefano Negripp. 267-277Medication Related Osteonecrosis of the Jaw: 2021 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons한정준, 김하영, 이성탁, 정준호, 권용대, 이정근, 김세화, 김덕윤, 이영균, 곽미경, 김진우pp. 279-296Effects of the Lysine Methyltransferase Inhibitor AZ505 on Bone Metabolism김민경, 송민경, 김홍희, 홍서진, 정수한, 권준오pp. 297-305
원문 보기