지방줄기세포를 이용한 골재생
Bone Regeneration from Adipose Stem Cells
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초록
광범위한 골결손은 현재의 기술로도 적절히 치료하기 힘들다. 최근 줄기세포를 이용한 치료기술의 발달에 의하여 앞으로는 조직공학적 기법에 의하여 골결손을 치유하는 것이 가능할 것으로 사료된다. 세포원으로 지방줄기세포는 가장 얻기쉬운 성체줄기세포이지만 골형성능이 낮은 것이 단점이다. 이를 극복하기 위하여 여러 방법들이 개발되고 있는데 본고에서는 지방줄기세포에서의 골형성 촉진방법에 대하여 문헌고찰과 함께 저자들의 경험을 소개하고자 한다.
Abstract
Reconstruction of large bone defect poses a great challenge to an orthopedic surgeon. Recent advancement in stem cell research ushered the treatment of bone defect with tissue-engineered bone into near-possibility. While adipose stem cells (ASCs) are the most available cell sources for tissue regeneration, their low osteogenic potential is a disadvantage. Several strategies have been developed to enhance the osteogenic differentiation of ASCs. In this review,we summarized literatures and our experience on the technology to promote osteogenesis from ASCs. [Korean Journal of Bone Metabolism, 18(1): 1-8, 2011]
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